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A comparative study on morphology and immunohistochemistry of rhabdomyosarcoma and embryonal skeletal muscles

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Chinese Medical Journal 1997年第5期 72-76页

作者：赖日权田野安建成周民伟邹国民李雯

Objective To investigate the histologic and histogenetic relationship between various types of rhabdomyosarcomas (RMS) and embryonal skeletal muscle (ESM) for further understanding of the histogenesis, classification and pattern of diferentiation of RMS. Methods Fifty cases of variant types of RMS and 20 cases of ESM at different gestational ages were available. All specimens were stained with HE, PAS, Van Gieson, Masson, phosphotungstic acid hematoxilin and with antibodies for the demonstration of vimentin, desmin, HHF 35 and myoglobin by ABC method. Results The results showed that the order of positive expression and the intensity of positive reaction of the different immunohistochemical staining were consistent with the degree of differentiation of the tumor and the development of the ESM. It is obvious that each type of RMS is composed of tumor cells in different degree of differentiation and is derived from primitive mesodermal cells which are capable of potential differentiation towards mature skeletal muscles. Conclusions Based on the results of this study, an ideal histologic classification of RMS should reflect not only the cell morphology and histologic structures but also the degree of differentiation of the tumor cells.

关键词：赖日权 muscles skeletal immunohistochemistry morphology embryonal comparative and

embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review

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Open Journal of Obstetrics and Gynecology 2014年第14期4卷 868-873页

作者： Khlifi Abdeljalil Boukadida Asma Mouna Kouira Hachani Faten Meddeb Sawssen Hidar Samir Bibi Mohamed Essaidi Habib Khairi Hedi Department of Gynecology and Obstetrics University Teaching Hospital Farhat Hached Sousse Tunisia

Introduction:?embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare and extremely aggressive malignant entity. However, prognosis seems to be improved with the use of multimodality approach treatment. Cases: We report the cases of 50- and 51-year-old women, presenting with vaginal bleeding and mass. The two patients underwent radical surgery. Histological examination revealed RMS of uterine cervix. Treatment was effective in the first case but despite the chemotherapy, the second patient died two months later. Discussion and Conclusions: The prognosis of the cervical embryonal RMS depends on clinical and histological features. The current treatment protocols are based on trials done on pediatric patients. Studies on embryonal RMS treatment and outcomes are limited in women over forty years. In patients with unfavorable prognosis characteristics, the multimodality approach including surgery, adjuvant chemo and radiotherapy can be effective. Otherwise, surgery alone can effectively be proposed.

关键词： embryonal Rhabdomyosarcoma Uterine Cervix Radiation Therapy Chemotherapy Surgery

embryonal Rhabdomyosarcoma of Middle Ear and Temporal Bone: A Rare Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第5期10卷 426-432页

作者： Gvs Rao Laxminath Ganji Shree Rao Chaitanya Rao Raja Sekhar Dr Raos ENT Superspeciality International Hospital Hyderabad India National Pathology Lab Hyderabad India

Introduction: Rhabdomyosarcoma accounts for up to 60% of childhood soft tissue sarcoma, occurring mostly in the head and neck region but rarely in the ear and temporal areas. Case Report: A 4-year-old boy came to our hospital due to a purulent discharge, bleeding from his left ear. Also seen mass in the left ear along with facial weakness and diplopia. After histopathologic evaluation, it was diagnosed as embryonal rhabdomyosarcoma. Conclusion: Rhabdomyosarcoma should be kept in mind as a differential diagnosis in all children presenting with otitis media with mastoiditis. Biopsy should be considered who are not responding to medications and those worsening condition.

关键词： Rhabdomyosarcoma (RMS) embryonal Temporal Bone Petrositis

Our Experience with embryonal Rhabdomyosarcoma Presenting as Aural Polyp

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第1期4卷 1-5页

作者： Anoop Attakkil Vandana Thorawade Mohan Jagade Rajesh Kar Dnyaneswar Rohe Reshma Hanowate Devkumar Rangaraja Kartik Parelkar Department of ENT Grant Medical College & Sir J.J. Hospital Mumbai India

Aural polyps are a common clinical entity encountered by otorhinolaryngologist in daily practice. Polyps are frequently seen in paediatric patients, usually inflammatory in nature. In children rhabdomyosarcomas (RMS) can mimic all the cinical features of chronic suppurative otitis media which usually present as external auditory canal mass or polyp. Here we present a case where a male child presented with recurrence of polyp in left ear which was finally diagnosed as embryonal rhabdomyosarcoma which is a rare and invariably fatal disease in children. Through this article we intend to highlight the failures and delay committed in attaining diagnosis in this patient in spite of multispecialty evaluation involving repeated imaging and histopathological correlation. Our experience with embryonal rhabdomyosarcoma throws light on the high vigilance required in handling the aural polyps in pediatric population as early diagnosis and treatment are the key elements for successful outcomes.

关键词： embryonal Rhabdomyosarcoma Aural Polyp CSOM

Primary embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review

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Open Journal of Urology 2012年第2期2卷 83-86页

作者： Pasquale Rescigno Giuseppe Di Lorenzo Lucia Raimondo Carmine D’Aniello Elide Matano Vincenzo Damiano Lucia Nappi Livio Puglia Antonella Petremolo Piera Federico Giovannella Palmieri Genitourinary Oncology and Rare Cancer Center Federico II University Naples Italy

Primary germ cell tumors of lung are extremely rare. The prognosis is usually poor, with various symptoms seriously affecting quality of life. In this paper we describe the unique case of a patient affected by an embryonal carcinoma of lung and a testicular seminoma after ten years. We also report literature about pulmonary extragonadal germ cell tumors.

关键词： Extragonadal Germ Cell Tumors Primary Pulmonary Germ Cell Tumor embryonal Carcinoma Testicular Seminoma

A case of prostate embryonal rhabdomyosarcoma in an adult patient

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Oncology and Translational Medicine 2019年第1期5卷 49-51页

作者： Qi Wei Zhiyong Sun Department of Urology East District of First Affiliated Hospital of Anhui Medical University (Feidong People's Hospital)

Prostate embryonal rhabdomyosarcoma(ERMS) is characterized by a high degree of malignancy, both local rapid growth with formation of large pelvic masses, often leading to renal failure due to urethra obstruction, and systemic spread, commonly to the lungs, liver, and bone. ERMS of the prostate is a commonly occurring tumor in infants and children. It is rarely seen in adults. Here, we report on a case of the prostate ERMS in a 27-year-old man.

关键词： prostate embryonal rhabdomyosarcoma surgery

胎儿的心脏的间充质的干细胞表示 embryonal 标记并且展出区别进所有三细菌层的房间

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World Journal of Stem Cells 2013年第1期5卷 26-33页

作者： Garikipati Venkata Naga Srikanth Naresh Kumar Tripathy Soniya Nityanand Stem Cell Research Facility Department of HematologySanjay Gandhi Post-Graduate Institute of Medical SciencesLucknow 226014India

AIM:To study the expression of embryonal markers by fetal cardiac mesenchymal stem cells(fC-MSC)and their differentiation into cells of all the germ layers. METHODS:Ten independent cultures of rat fCMSC were set up from cells derived from individual or pooled fetal hearts and studies given below were carried out at passages 3,6,15 and *** phenotypic markers CD29,CD31,CD34,CD45,CD73,CD90, CD105,CD166 and HLA-DR were analyzed by flow *** expression of embryonal markers Oct-4, Nanog,Sox-2,SSEA-1,SSEA-3,SSEA-4,TRA-1-60 and TRA 1-81 were studied by *** fC-MSC treated with specific induction medium were evaluated for their differentiation into(1)adipocytes and osteocytes(mesodermal cells)by Oil Red O and Alizarin Red staining,respectively,as well as by expression of lipoprotein lipase,PPARγ2 genes in adipocytes and osteopontin and RUNX2 genes in osteocytes by reverse-transcription polymerase chain reaction(RT- PCR);(2)neuronal(ectodermal)cells by expression of neuronal Filament-160 and Glial Fibrillar Acidic Protein by RT-PCR and immunocytochemistry;and(3)hepa- tocytic(endodermal)cells by expression of albumin by RT-PCR and immunocytochemistry,glycogen deposits by Periodic Acid Schiff staining and excretion of urea into the culture supernatant. RESULTS:The fC-MSC expressed CD29,CD73,CD90, CD105,CD166 but lacked expression of CD31,CD34, CD45 and *** expressed embryonal markers,***-4,Nanog,Sox-2,SSEA-1,SSEA-3,SSEA-4, TRA-1-81 but not *** treatment with specific induction media,they differentiated into adipocytes and osteocytes,neuronal cells and hepatocytic cells. CONCLUSION:Our results together suggest that fCMSC are primitive stem cell types with a high degree of plasticity and,in addition to their suitability for cardiovascular regenerative therapy,they may have a wide spectrum of therapeutic applications in regenerative medicine.

关键词： Fetal cardiac mesenchymal stem cells embryonal markers Multipotent differentiation potential

Akt–Oct4 regulatory circuit in pluripotent stem cells

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Chinese Science Bulletin 2014年第10期59卷 936-943页

作者： Tong Su Songsong Dan Yingjie Wang College of Life Sciences Zhejiang University Chu KoChen Honors College Zhejiang University State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of MedicineZhejiang University

Oct4 is mainly expressed in embryonic stem cells(ESCs),germline stem cells,and embryonal carcinoma cells(ECCs)and plays an indispensable role in maintaining the pluripotency and self-renewal of these pluripotent stem *** serine/threonine kinase,a wellestablished anti-apoptosis and cell survival factor,has also been implicated as an important regulator of *** evidence indicated that Oct4 is reciprocally connected to Akt via a number of routes,and moreover,a direct interaction between Oct4 and Akt has recently been *** components collectively form the Akt–Oct4 regulatory *** this review,we summarize our current knowledge about the Akt–Oct4 regulatory circuit in ESCs and discuss its alterations in ECCs that may underlie the tumorigenesis of pluripotent stem cells.

关键词： Oct4 Akt Embryonic stem cells embryonal carcinoma cells

Effect of Growth Regulators on Seed Germination and Its Significance in the Management of <i>Aeginetia indica</i>L. —A Root Holoparasite

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American Journal of Plant Sciences 2012年第10期3卷 1490-1494页

作者： Chellopil Raman Vijay Mallegowdanakoppalu Channappa Thriveni Gyarahally Rangappa Shivamurthy Department of Studies in Botany University of Mysore Manasagangotri Mysore India Maharani’s Science College for Women Mysore India

Seed germination in root holoparasites depends on receipt of certain chemical signals from the host plant. It is possible to induce germination in such seeds without the association of hosts by using growth regulators under in vivo and in vitro conditions. IAA, GA3 and Kinetin have been used to induce seed germination in Aeginetia indica L. to analyse the possible ways of exploiting knowledge of germination for the management of this weed. Seeds pre treated with 50 mg·L–1 of GA3 showed the production of aseptate, uninucleate root hair-like tubules, which probably help in the anchorage with host root. Under in vitro, GA3 (5.0 and 7.5 mg·L–1) has been found to induce and enhance percentage of seed germination. Therefore, it is concluded that GA3 could be used to bring suicidal germination of seeds thereby manage this parasitic weed effectively. Further production of uninucleate tubules and organisation of conventional bi-polar seedling under the influence of GA3 is being reported for the first time in this taxon.

关键词： Aeginetia indica Seed Germination Suicidal Germination Growth Regulators embryonal Tubules