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emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats

Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 21-25页

作者： Aneesa Ansari Md.Shahed Zaman Shahriar Md.Mehedi Hassan Shukla Rani Das Begum Rokeya Md.Anwarul Haque Md.Enamul Haque Nirupam Biswas Tama Sarkar Department of Genetic Engineering and Biolechnology Jessore Science and Technology UniversityJessoreBangladesh Department of Biotechnology and Genetic Engineering Islamic UniversityKushtiaBangladesh Department of Biomedical Science Chonbuk National University Medical SchoolJeonju 561-712South Korea Department of Biochemistry and Molecular Biology Hajee Mohammad Danesh Science & Technology UniversityDinajpurBangladesh Department of Biochemistry and Cell Biology Bangladesh Institute of Research and Rehabilitation in DiabetesEndocrine and Metabolic Disorders (BIRDEM)DhakaBangladesh Department of Biochemistry and Molecular Biology University of DhakaDhaka-1000Bangladesh Department of Nutrition and Food Sciences University of HuddersfieldHuddersfiledHD1 3DHUnited Kingdom Department of Applied Nutrition and Food Technology Islamic UniversityKushtiaBangladesh

Objective:To evaluate the antidiabetic and antioxidant potential of emblica officinalis(***)fruit on normal and type 2 diabetic ***:Type 2 diabetes was induced into the male Long-Evans *** rats were divided into nine groups including control groups receiving water,type 2 diabetic controls,type 2 diabetic rats treated with glibenclamide(T2GT)and type 2diabetic rats treated with aqueous extract of fruit pulp of *** were fed orally for8 weeks with a single *** was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 *** red blood cells and serum were used for evaluating different biochemical ***:Four weeks administration of aqueous extract of *** improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant(P<0.007)reduction in fasting serum glucose level compared to 0 *** decreased by 14%but there was no significant change in serum ALT,creatinine,cholesterol and insulin level in any ***,reduced erythrocyte malondialdehyde level showed no significant change(P<0.07)but reduced glutathione content was found to be increased significantly(P<0.05).Conclusions:The aqueous extract of *** has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.

关键词： Antioxidant emblica officinalis Non-insulin dependent diabetes mellitus Type 2 diabetic rats Reduced glutathione

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Anti-diabetic activity of quercetin extracted from Phyllanthus emblica ***: In silico and in vivo approaches

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Journal of Pharmaceutical Analysis 2018年第2期8卷 109-118页

作者： Prabhu Srinivasan S.Vijayakumar Swaminathan Kothandaraman Manogar Palani Computational Phytochemistry Lab PG and Research Department of Botany and Microbiology A. V. V. M Sri Pushpam College (Autonomous) Department of Physics RKM Vivekananda College (Autonomous)

In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies.

关键词： Bioactive molecules Glycogen phosphorylase Molecular docking Phyllanthus emblica Quercetin Albino Wister male rats

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Synergistic anti - Staphylococcus aureus activity of amoxicillin in combination with emblica officinalis and Nymphae odorata extracts

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Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 711-714页

作者： Shyamapada Mandal Manisha DebMandal Nishith Kumar Pal Krishnendu Saha Department of Microbiology Bacteriology and Serology UnitCalcutta School of Tropical MedicineC.R.AvenueKolkata-700 073India Department of Physiology and Biophysics KPC Medical College and Hospital1F Raja S C Mallick RoadJadavpurKolkata-700 032India

Objective:To evaluate the antibacterial activity of emblica officinalis Gaertn(***: Family:Euphorbiaceae) seed and Nymphae odorala Aiton(***:Family:Nymphaeaceae) stamen extracts,alone and in combination,and in combination with amoxicillin(Ax) against Staphylococcus aureus(***).Methods:Antibacterial activity of ethanolic extracts of amla,***,seed(AMS:500μg) and sapla,***,stamen(SAP:500 p g) for 12 methicillin-resistant ***(MRSA) isolates was determined following agar diffusion:in order to assess the combined antibacterial activity,AMS(250μg) plus SAP(250μg) were *** Ax(10μg) activity alone and in combination with AMS(250μg),and SAP(250μg) was determined by disk *** zone diameters of inhibition(ZDIs) for the agents were recorded,and growth inhibitory indices(GIIs) were ***:The MRSA isolates (n=12) had AMS(500μg) and SAP(500μg) ZDIs of 12-19 mm and 21-24 mm,*** ZDIs(range 24-27 mm) increased by 3-4 mm due to combined action of AMS(250μg) and SAP(250μg) indicating synergy between extracts for MRSA(GII 0.634-0.742).The MRSA isolates were resistant to Ax(ZDI:8-11 mm),which in combination with AMS and SAP had synergistic effect,both due to increased ZDI[mean±SD=(3.5±0.577) mm]and GII(0.631-0.894).Conclusions:The data suggest that the plants,*** and *** alone or in combination,are promising in the development of phytomedicines,which may be used,alone or in combination with the antibiotic. Ax,against MRSA infection.

关键词： Antibacterial activity Plant extract Amoxicillin emblica officinalis Nimphae odorata Synergy MRSA

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Effect of Phyllanthus emblica *** Candida adhesion to oral epithelium and denture acrylic

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Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 41-45页

作者： Boonyanit Thaweboon Sroisiri Thaweboon Department of Oral Microbiology Faculty of DentistryMahidol University6 Yothi RoadRajtheveeBangkok 10400Thailand

Objective:To investigate the effect of Phyllanthus emblica(***) Linn,ethanolic extract on the adhesion of Candida albicans(***) to human buccal epithelial cells(BECs) and denture acrylic ***:Human BECs and transparent acrylic strips were pretreated with ethanolic extract solution of *** fruits at concentration ranged from 18.7 to 300 mg/*** washing BECs and the strips were inoculated with three strains of *** (ATCC 10281 and two clinical isolates)(10~7 cells/mL).Normal saline solution(NSS) and 0.2% chlorhexidine gluconate were used as negative and positive controls,*** were harvested on 12μm-polycarbonate filters(Millipore,USA).The membrane filters and the strips were stained with Gram *** yeast cells on 100 randomly selected epithelial cells and 20 randomly selected fields on each strip were counted under *** statistical significance was calculated by Kruskal-Wallis and Tukey tests at a significant level of P<0.05. Results:Significant lower numbers of all strains of yeasts adhering to BECs and acrylic strips were observed after exposure to 75-300 mg/mL of plant extract compared with ***: The present study demonstrates that *** ethanolic extract interferes with the adhesion of C. albicans to BECs and denture acrylic surfaces in vitro.

关键词： Phyllanthus emblica Candida Adhesion Oral epithelium Denture Acrylic

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Investigation of the Phytoconstituents and Bioactivity of Various Parts of Wild Type and Cultivated Phyllanthus emblicaL.

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Advances in Bioscience and Biotechnology 2017年第7期8卷 211-227页

作者： Ratna Mondal Shakil Ahmed Polash Tanushree Saha Zinia Islam Md. Maniruzzaman Sikder Nuhu Alam Md. Sharif Hossain Satya Ranjan Sarker Department of Biotechnology and Genetic Engineering Jahangirnagar University Savar Dhaka Bangladesh Department of Textile Engineering Dhaka University of Engineering and Technology Gazipur Bangladesh Department of Botany Jahangirnagar University Savar Dhaka Bangladesh

Phyllanthus emblica L. belonging to the family Euphorbiaceae is a common medicinal plant in Bangladesh. In order to evaluate the phytoconstituents and bioactivity of various parts of P. emblica, both the wild type (i.e., small) and cultivated (i.e., big) fruits were collected from the local market of Bangladesh and six ethanolic extracts were prepared from various parts of the collected fruits for this current study. A comparative analysis of the phytochemical compositions and various bioactivities especially antibacterial, antifungal, and antioxidant activity of the six ethanolic extracts were accomplished. The qualitative phytochemical analysis of plant extracts revealed the presence of large amounts of proteins, carbohydrates, phenolic compounds, glycosides, alkaloids, coumarins, flavonoids, tannins, saponins and resins etc. The maximum antioxidant activity was observed for wild type P. emblica seed extracts and the minimum activity was observed for cultivated flesh extracts. Moreover, among the samples the wild type P. emblica extracts have excellent amount of total phenol contents and the highest free radical scavenging activity. It is also found that P. emblica samples were active against both gram-positive (i.e., B. subtilis) and gram-negative (i.e., E. coli, and S. typhi) bacteria. The highest antibacterial activity was achieved in the wild type P. emblica seed extracts against both pathogenic (S. typhi) and non-pathogenic bacterial strains (E. coli, and B. subtilis). These samples showed almost no activity against Fusarium sp. fungus.

关键词： Phyllanthus emblica Total Phenol Content Antioxidant Activity Antimicrobial Activity Zone of Inhibition and Antifungal Activity

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Investigation of Antidiabetic Effect of Ethanolic Extract of Phyllanthus emblicaLinn. Fruits in Experimental Animal Models

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Pharmacology & Pharmacy 2014年第1期5卷 11-18页

作者： Zakia Sultana Safkath Ibne Jami Ershad Ali Marium Begum Mominul Haque Department of Chemistry and Biomolecular Sciences Macquarie University Macquarie Park Australia. Department of Chemistry Dhaka College National University Dhaka Bangladesh Department of Pharmacy University of Asia Pacific Dhaka Bangladesh Department of Pharmacy University of Rajshahi Rajshahi Bangladesh

Hypoglycemic effects were investigated in the ethanolic extract of fruits of Phyllanthus emblica Linn. with long evans rats (100-120 g). Residual gut sucrose content, gut perfusion and disaccharidase activity studies were carried out to assess these activities. The residual gut sucrose content study was carried out to reveal the amount of sucrose remaining in the gastro intestinal tract (GIT) at six different segments. The ethanolic fruit extract of Phyllanthus emblica Linn. significantly increases the residual sucrose content throughout the gut after sucrose ingestion. Study on intestinal enzyme activity showed that the extract caused a significant (p 0.05), dose dependent inhibition of intestinal disaccharidase enzyme activity. Evaluation of the effect of the plant extract on intestinal enzyme activity showed significant inhibition of intestinal disaccharidase activity, suggesting that reduction of sucrose absorption may be partly related to the inhibition of disaccharidase activity in the gut. The gut perfusion analysis showed that the extract significantly reduced intestinal glucose absorption. The results of the present study suggest that ethanolic extract of Phyllanthus emblica Linn. has significant antidiabetic effects in a dose dependent manner and this may be effective in the treatment of diabetes.

关键词： Phyllanthus emblica Ethanolic Extract Antidiabetic Effects Disaccharidase Activity

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Prolonged Seed Dormancy in Phyllanthus emblicaL. Can Be Overturned by Seed Scarification and Gibberellin Pre Treatment

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Open Journal of Forestry 2014年第1期4卷 38-41页

作者： S. M. U. P. Mawalagedera G. A. D. Perera S. D. S. S. Sooriyapathirana Department of Botany Faculty of Science University of Peradeniya Peradeniya Sri Lanka Department of Molecular Biology and Biotechnology Faculty of Science University of Peradeniya Peradeniya Sri Lanka

Phyllanthus emblica L. is an important constituent of Ayurvedic medicine and a fresh fruit species in the market in Sri Lanka. Therefore, it has a high potential to be established as a commercial fruit crop. The seeds of P. emblica are semi orthodox and exhibit a long dormancy period hindering the natural sexual propagation. Therefore, it still remains as an underutilized fruit crop in Sri Lanka due to its lack of quality planting material and poor propagation techniques. Long term dormancy also causes a big challenge in germinating seeds to create populations in breeding programs. In order to promote P. emblica from its underutilized status, what seems most feasible is to develop a method to break up the seed dormancy artificially. In order to do so, the methods of breaking the dormancy of P. emblica seeds have to be studied. Therefore, the aim of this study was to identify a method to break up the seed dormancy of P. emblica. The seeds were extracted from 21 trees belonging to three different districts in Sri Lanka. The selected viable seeds were subjected to four different pre treatments: none treated seeds (i.e. control), seeds scarified, seeds scarified and treated with 1% gibberellin and seed coat removed and followed by seeds treated with 1% gibberellin. From the four treatments, seed dormancy was overturned with a germination percentage of 43% by the seed pre treatment where the seeds were scarified and treated with 1% gibberellin and no other pre treatment methods were successful in breaking the dormancy. This suggests that the natural germination potential of P. emblica seeds is very low and it can be overridden by seed scarification and gibberellin pre treatment.

关键词： Gibberellin Pre Treatment Phyllanthus emblica Seed Dormancy Seed Scarification

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Effect of Total Flavonoids from Phyllanthus emblica L. on Tumor Proliferation and Immune Function

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Medicinal Plant 2020年第1期11卷 51-54页

作者： Wenya CHEN Erchu GUO Zhenguo ZHONG Guangxi University of Chinese Medicine Nanning 530001China

[Objectives]To explore the effect of total flavonoids from Phyllanthus emblica *** tumor proliferation and immune function.[Methods]The effects of total flavonoids of *** *** the proliferation of 6 different tumor cell lines(human hepatoma cell line HepG-2,human cervical cancer cell line Hela,human gastric cancer cell line SGC7901,human nasopharyngeal carcinoma cell line CNE-2,human lung cancer cell line H460 and human ovarian cancer cell line A2780)were compared by SRB *** effect of total flavonoids from *** *** the proliferation of mouse lymphocytes induced by concanavalin(ConA)or lipopolysaccharide(LPS)in vitro was detected by CCK-8 method.[Results]The results of SRB assay showed that compared with the normal group,the total flavonoids of *** *** obvious inhibitory effect on 6 kinds of tumor *** them,the inhibitory effect on H460 cells and CNE-2 cells was the most significant,and the IC50 was(471.36±50.66),(463.26±40.75)μg/mL,*** high dose group of total flavonoids from *** *** the same inhibitory effect as the positive drug *** results of CCK-8 assay showed that compared with the blank group,the total flavonoids of *** *** inhibited the proliferation of mouse lymphocytes induced by ConA or LPS(*P<0.05,**P<0.01).[Conclusions]The total flavonoids of *** *** significant anti-tumor activity.

关键词： Phyllanthus emblica L. Total flavonoids Anti-tumor Immune function

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Phytochemical analysis and anticancer capacity of Shemamruthaa,a herbal formulation against DMBA-induced mammary carcinoma in rats

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Asian Pacific Journal of Tropical Medicine 2013年第12期6卷 925-933页

作者： Ayyakkannu Purushothaman Elumalai Nandhakumar Panchanatham Sachdanandam Department of Medical Biochemistry.Dr.ALM Post-Graduate Institute of Basic Medical Sciences University of MadrasTaramani CampusChennai-600113 .India

Objective:To investigate the bioactive-constituents of Shemamruthaa(SM),a herbal combination and its therapeutic effects on the mitochondrial functions with reference to lipid peroxidation(LPO),antioxidant status,citric acid cycle enzymes and electron transport chain enzymes in mammary tissues of 7,12-dimethylbenz(a)-anthracene(DMBA)induced mammary carcinoma in rat ***:Adult Female Sprague-Dawley rats were used for the study and were divided into four ***Ⅰserved as control and CroupⅡrats were induced mammary carcinoma by administration of DMBA(25 mg/kg b.w.)*** normal and cancer-induced rats(GroupⅢ)were treated with SM(400 mg/kg b.w./day)orally by gastric incubation for ***Ⅳrats served as SM-treated control ***:Cancer-induced rats showed a considerably increased level of LPO with concomitant decreased levels of antioxidants,citric acid cycle enzymes,electron transport chain enzymes and cytochrome contents in the mammary *** with SM brought back the aforementioned biochemical parameters to near ***:From the results,it can be inferred that Shemamruthaa possesses significant anticancer effect through its role in attenuation of LPO,prevention of membrane damage and restoring membrane integrity.

关键词： Phyllanthus emblica Hibiscus rosa-sinensis Mammary carcinoma Trilinolein Flavonoids Mitochondrial oxidative stress

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“保山2号”余甘子优良无性系选育

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林业科技通讯 2018年第6期 3-6页

作者：罗存贞郭俊杰黄佳聪张炜李归林保山市林业技术推广总站云南保山678000 保山市林业科学研究所云南保山678000 中国林业科学研究院热带林业研究所广州510520

＂保山2号＂余甘子（Phyllanthus emblica Linn.）是经过优树选择、无性系测定、区域栽培试验、DNA指纹图谱检测比对培育的优良无性系品种。其树姿开张,生长势中庸,耐修剪;集约化栽培条件下,1.5年龄嫁接苗种植后,2年进入初产期,第3-4年... 详细信息

＂保山2号＂余甘子（Phyllanthus emblica Linn.）是经过优树选择、无性系测定、区域栽培试验、DNA指纹图谱检测比对培育的优良无性系品种。其树姿开张,生长势中庸,耐修剪;集约化栽培条件下,1.5年龄嫁接苗种植后,2年进入初产期,第3-4年进入盛产期,为极端早实品种,具丰产稳产特性;4月上旬开花,9月中旬果实成熟;单果平均质量16.38g,果形指数0.79,可食率84.3%,果皮光滑、翠绿色,口感稍坚硬、细腻、回甘性好;果肉含Vc 4.7g/kg、粗纤维2.05%、总糖7.7%、总酸1.79%、可溶性固形物11.2%,水分84.4%。

关键词：余甘子 Phyllanthus emblica Linn. 无性系 “保山2号” 选育

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