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elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： Zhenzhen Fang Gang Shen Yina Wang Fuyan Hong Xiumei Tang Yongcheng Zeng Ting Zhang Huanyi Liu Yanmei Li Jinhong Wang Jing Zhang Anton Gao Weiwei Qi Xia Yang Ti Zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic ***(HLP)is the leading risk factor for *** study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were *** plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver ***,KAL levels of NAFLD patients were significantly *** transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)*** contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD ***,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),***-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa ***,hepatic CGl-58-overexpress reverses NASH in KAL transgenic ***,free fatty acids up-regulated KAL against thyroid hormone in ***,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating *** results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

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Discovery of a normal-tension glaucoma-suspect rhesus macaque with craniocerebral injury:Hints of elevated translaminar cribrosa pressure difference

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Chinese Medical Journal 2024年第4期137卷 484-486页

作者： Jian Wu Qi Zhang Xu Jia Yingting Zhu Zhidong Li Shu Tu Ling Zhao Yifan Du Wei Liu Jiaoyan Ren Liangzhi Xu Hanxiang Yu Fagao Luo Wenru Su Ningli Wang Yehong Zhuo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-sen UniversityGuangzhouGuangdong 510060China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China School of Food Sciences and Engineering South China University of TechnologyGuangzhouGuangdong 510641China Guangzhou Huazhen Biosciences GuangzhouGuangdong 510920China

To the Editor:Normal-tension glaucoma(NTG)is a progressive optic neuropathy characterized by irreversible blindness with statistically normal intraocular pressure(IOP)(≤21 mmHg),^([1,2])which makes early-stage diagnosis in the clinical practice *** pathways underlying NTG include vascular dysregulation,toxic metabolite accumulation,and elevated translaminar cribrosa pressure difference(TLCPD).^([3])Although various small animal models have provided evidence of different pathophysiological mechanisms,the complicated clinical phenotype cannot be fully imitated by secondary disease models,and the gap between rodents and humans weakens their translational ***,the pathological changes associated with NTG remain unclear.

关键词： elevated glaucoma diagnosis

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Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

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Neural Regeneration Research 2025年第8期20卷 2317-2318页

作者： Francesco Angelucci Jakub Hort Memory Clinic Department of NeurologySecond Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International Clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic

Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the *** pathology involves a series of cognitive,behavioral,and neurological ... 详细信息

关键词： degeneration elevated pathology

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elevated temperature wear behaviour of CeO_2 modified WC-12Co coating

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Journal of Rare Earths 2019年第6期37卷 673-678页

作者： Yan Liu Guiying Yang Zongqiu Hang Hao Fu Naiyuan Xi Hui Chen School of Materials Science and Engineering Southwest Jiaotong University

With the service environment becoming more and more severe, WC-Co coatings are required to apply in high temperature wear condition. In the present study, the sliding wear tests of CeO_2 modified WC-12 Co coatings were conducted at temperature of 450, 550 and 650 ℃. The wear loss and friction coefficient were recorded. The morphologies of wear tracks were observed every 1 h to investigate the dynamic wear mechanisms. The results show that the volume wear loss decreases with temperature *** lowest volume wear loss is obtained at the temperature of 650 ℃ due to oxide films generated in the process of wearing. The wear mechanism is different at the temperature of 450, 550 and 650 0 C. Micro cutting wear, abrasive wear and oxidation wear dominate the wear mechanism at 450, 550 and 650 ℃,respectively. Abrasive wear and oxidation wear are the wear mechanisms at various temperatures.

关键词： CeO2 modified WC-12Co coating Dynamic process elevated temperature wear mechanism Rare earths

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elevated temperature intensity,timing,and duration of exposure affect soybean internode elongation,mainstem node number,and pod number per plant

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The Crop Journal 2018年第2期6卷 148-161页

作者： Leon Hartwell Allen Jr. Lingxiao Zhang Kenneth J.Boote Bernard A.Hauser U.S.Department of Agriculture-Agricultural Research Service GainesvilleFL 32608USA Department of Agronomy University of FloridaGainesvilleFL 32611USA Department of Biology University of FloridaGainesvilleFL 32611USA

A study was conducted in four compartments of a polycarbonate greenhouse at Gainesville,FL, USA to investigate how a soybean(Glycine max L. Merr.) cultivar, Maverick(maturity group III, indeterminate), responded to three elevated temperatures, ELT,(day/night of 34/26 °C, 38/30 °C, and 42/34 °C) in comparison to a control growth temperature(30/22 °C).Carbon dioxide(CO_2) concentration was maintained at 700 μmol mol^(-1) in each compartment by a processor controlled air-sampling and CO_2-injection system. Three sequential experiments were conducted at different times of year(summer, autumn, and early spring)to investigate the effect of intensity, timing, and duration of ELT on soybean node number,internode elongation, mainstem length, and number of pods set per plant. At the control temperature, the soybean plants grown in the polycarbonate greenhouse were taller than field-grown plants. When plants were grown under continuous ELT applied soon after sowing or at initial flowering, the number of nodes increased with increasing ELT intensity,whereas the length of individual internodes decreased. When ELT treatment was applied during the beginning of flowering stage(R1–R2) or earlier, more nodes were produced and the length of affected internodes was decreased. When the ELT was imposed later at reproductive stage R5+ just before the beginning of seed filling, effects on node numbers and internode lengths were negligible. Short-term(10-day) duration of ELT applied at four stages from V3 to R5+ did not significantly affect final mean numbers of nodes or mean mainstem lengths. Possible mechanisms of elevated temperature effects on soybean internode elongation and node number(internode number) are discussed. Total pod numbers per plant increased linearly with mainstem node numbers and mainstem ***, total pod numbers per plant were greatest at 34/26 °C rather than at the control temperature of 30/22 °C(and remained high at 38/30 °C). Mild increases in temperatu

关键词： elevated temperature Internode elongation Node number Pod yield Soybean phenology

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An experimental study of ultra-high temperature ceramics under tension subject to an environment with elevated temperature,mechanical stress and oxygen

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Science China(Technological Sciences) 2019年第8期62卷 1349-1356页

作者： HAN XinXing XU ChengHai JIN Hua XIE WeiHua MENG SongHe National Key Laboratory of Science and Technology for National Defence on Advanced Composites in Special Environments Harbin Institute of Technology

Ultra-high temperature ceramic(UHTC) composites are widely used in high-temperature environments in aerospace applications. They experience extremely complex environmental conditions during service, including thermal, mechanical and chemical loading. Therefore, it is critical to evaluate the mechanical properties of UHTCs subject to an environment with elevated temperature, mechanical stress and oxygen. In this paper, an experimental investigation of the uniaxial tensile properties of a ZrB_2-SiC-graphite subject to an environment with a simultaneously elevated temperature, mechanical stress and oxygen is conducted based on a high-temperature mechanical testing system. To improve efficiency, an orthogonal experimental design is used. It is suggested that the temperature has the most important effect on the properties, and the oxidation time and stress have an almost equal effect. Finally, the fracture morphology is characterized using scanning electron microscopy(SEM), and the mechanism is investigated. It was concluded that the main fracture mode involved graphite flakes pulling out of the matrix and crystalline fracture, which indicates the presence of a weak interface in the composites.

关键词： ultra-high temperature ceramics environment with elevated temperature mechanical stress and oxygen uniaxial tensile strength orthogonal experimental design

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Shock response of cyclotetramethylene tetranitramine(HMX)single crystal at elevated temperatures

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Defence Technology（防务技术） 2023年第3期21卷 147-163页

作者： Kai Ding Xin-Jie Wang Zhuo-Ping Duan Yan-Qing Wu Feng-Lei Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081PR China

To investigate the shock response of cyclotetramethylene tetranitramine(HMX)single crystals at elevated temperatures(below the phase transition point),plate impact experiments at elevated temperatures were designed and *** HMX/window interface particle velocities at temperatures of 300 K,373 K,and 423 K were measured by the velocity interferometry system for any reflector(VISAR)*** further analyze the related mesoscale deformation mechanisms,a nonlinear thermoelastic-viscoplastic model was developed,which considers thermal activation and phonon drag dislocation slip *** proposed model could well reproduce the measured thermal hardening behavior of Hugoniot elastic limit(HEL)of HMX single *** elevated temperatures,the reduced dislocation mobility was observed,which stems from both phonon scattering and radiative damping *** speaking,radiative damping contributes less than phonon scattering to thermal hardening *** calibrated model was further used to predict shock response of HMX single crystals with different thicknesses at different initial *** the stress relaxation and elastic precursor decrease with thickness are mainly due to the rapid dislocation *** insights shed light on the interplay between dislocation motion and dislocation generation in thermal hardening behavior,stress relaxation,and elastic precursor decay,which serves to reveal the mesoscale deformation mechanisms at elevated temperatures.

关键词： deformation elevated dislocation

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Mechanism of Mg2+ dissolution from olivine and serpentine: Implication for bioleaching of high-magnesium nickel sulfide ore at elevated pH

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International Journal of Minerals,Metallurgy and Materials 2019年第9期26卷 1069-1079页

作者： Jian-zhi Sun Jian-kang Wen Bo-wei Chen Biao Wu National Engineering Laboratory of Biohydrometallurgy GRINM Group Corporation Limited

To inhibit the dissolution of Mg^2+ during the bioleaching process of high-magnesium nickel sulfide ore, the effect of major bioleaching factors on the dissolution of Mg^2+ from olivine and serpentine was investigated and kinetics studies were carried out. The results indicated that the dissolution rate-controlling steps are chemical reaction for olivine and internal diffusion for serpentine. The most influential factor on the dissolution of Mg^2+ from olivine and serpentine was temperature, followed by p H and particle size. A novel method of bioleaching at elevated pH was used in the bioleaching of Jinchuan ore. The results showed that elevated pH could significantly reduce the dissolution of Mg^2+ and acid consumption along with slightly influencing the leaching efficiencies of nickel and cobalt. A model was used to explain the leaching behaviors of high-magnesium nickel sulfide ore in different bioleaching systems. The model suggested that olivine will be depleted eventually, whereas serpentine will remain because of the difference in the rate-controlling steps. Bioleaching at elevated pH is a suitable method for treating high-magnesium nickel sulfide ores.

关键词： olivine serpentine high-magnesium nickel sulfide ore bioleaching shrinking core model elevated pH

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Eutectic mixture promoted CO_2 sorption on MgO-TiO_2 composite at elevated temperature

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Journal of Environmental Sciences 2019年第2期31卷 80-88页

作者： Vishwanath Hiremath Monica Louise T.Trivino Jeong Gil Seo Department of Energy Science and Technology Myongji University

The development of carbon dioxide(CO_2) sorbents that can operate at elevated temperatures is significant for the advancement of pre-combustion capture ***, promoter-based systems composed of alkali/alkaline earth metal nitrates and/or carbonates have been considered as next-generation solid sorbents due to their improved CO_2 uptake and kinetics. However, obtaining stable MgO sorbents against temperature swing regeneration still remained challenging. Herein, we report MgO-TiO_2 solid sorbents promoted by eutectic mixture(KNO_3 and LiNO_3) for elevated temperature CO_2 sorption. The developed sorbents show improved CO_2 sorption capacity, which may be attributed to the alternative CO_2 sorption pathway provided by the ionization of highly dispersed MgO in the eutectic mixture. The MgO-TiO_2 framework was also shown to assist in retaining the MgO configuration by constraining its interaction with CO_2. Furthermore, it is demonstrated that constructing composite structures is essential to improve the CO_2 sorption characteristics,mainly recyclability, at elevated temperatures. The developed promoter integrated sorbents showed exceptionally high CO_2 sorption capacity of > 30 wt.% at an elevated temperature(300°C) with pronounced stability under temperature swing operation.

关键词： MgO-TiO2 composite elevated temperature CO2 capture Eutectic mixture promoter MgO stability

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Deflection behavior of a prestressed concrete beam reinforced with carbon fibers at elevated temperatures

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Frontiers of Structural and Civil Engineering 2019年第1期13卷 81-91页

作者： Mohammed FARUQI Mohammed Sheroz KHAN Department of Civil and Architectural Engineering Texas A&M University--KingsvilleTexasUSA

Fiber reinforced polymer(FRP) have unique advantages like high strength to weight ratio,excellent corrosion resistance,improving deformability and cost *** advantages have gained wide acceptance in civil engineering *** tendons for prestressing applications are emerging as one of the most promising technologies in the civil engineering ***,the behavior of such members under the influence of elevated temperatures is still *** knowledge and application of this could lead to a cost effective and practical considerations in fire safety ***,this study examines the deflection behavior of the carbon fiber reinforced polymer(CFRP) prestressed concrete beam at elevated *** this article,an analytical model is developed which integrates the temperature dependent changes of effective modulus of FRP in predicting the deflection behavior of CFRP prestressed concrete beams within the range of practical *** model is compared with a finite element mode (FEM) of a simply supported concrete beam prestressed with CFRP subjected to practical elevated *** addition,comparison is also made with an indirect reference to the real behavior of the *** results of the model correlated reasonably with the finite element model and the real ***,a practical application is provided.

关键词： FRP CFRP concrete elevated temperatures deflections prestress

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