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Quantitative determination of the electron beam radiation dose for SARS-CoV-2 inactivation to decontaminate frozen food packaging

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Virologica Sinica 2022年第6期37卷 823-830页

作者： Zihao Wang Zhentao Liang Rongguo Wei Hongwei Wang Fang Cheng Yang Liu Songdong Meng Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Department of Clinical Laboratory The Fifth Affiliated Hospital of Guangxi Medical UniversityNanning530022China China Isotope and Radiaton Corporation Beijing100089China Changchun CNNC CIRC radiation Technology Co. LTDChangchun130022China

The spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) from cold-chain foods to frontline workers poses a serious public health threat during the current global pandemic. There is an urgent need to design concise approaches for effective virus inactivation under different physicochemical conditions to reduce the risk of contagion through viral contaminated surfaces of cold-chain foods. By employing a time course of electron beam exposure to a high titer of SARS-CoV-2 at cold-chain temperatures, a radiation dose of 2 kGy was demonstrated to reduce the viral titer from 10^(4.5)to 0 median tissue culture infectious dose(TCID_(50))/mL. Next,using human coronavirus OC43(HCoV-OC43) as a suitable SARS-CoV-2 surrogate, 3 kGy of high-energy electron radiation was defined as the inactivation dose for a titer reduction of more than 4 log units on tested packaging materials. Furthermore, quantitative reverse transcription PCR(RT-qPCR) was used to test three viral genes,namely, E, N, and ORF1ab. There was a strong correlation between TCID50and RT-qPCR for SARS-CoV-2detection. However, RT-qPCR could not differentiate between the infectivity of the radiation-inactivated and nonirradiated control viruses. As the defined radiation dose for effective viral inactivation fell far below the upper safe dose limit for food processing, our results provide a basis for designing radiation-based approaches for the decontamination of SARS-CoV-2 in frozen food products. We further demonstrate that cell-based virus assays are essential to evaluate the SARS-CoV-2 inactivation efficiency for the decontaminating strategies.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Inactivation electron beam radiation Food decontamination Cold-chain

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Preparation of Magnetic CS/(GMA-AM) Hydrogels with electron beam radiation and it's Adsorption properties of Methyl Orange

Preparation of Magnetic CS/(GMA-AM) Hydrogels with Electron ...

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第十一届全国高聚物分子与结构表征学术研讨会

作者： Tao Chen Yiping Ke Xinyue Liu Ziyan Tan Libing Zhang Yuan Zhao Hubei University of Science and Technology

With the rapid development of industry, the problem of water pollution is becoming more and more serious, and the pollution of printing and dyeing wastewater is particularly prominent. In this study, chitosan was used as a raw material and was thoroughly mixed with modified FeO. It was added to a dispersion medium consisting of liquid paraffin, petroleum ether, and emulsifier Tween-80. High-speed stirring emulsification and addition of glutaraldehyde crosslinker were used. The magnetic chitosan microspheres were obtained;then the functionalized magnetic chitosan microspheres were obtained by grafting glycidyl methacrylate and acrylamide by preirradiation with electron beam, then adsorption performance of methyl orange was studied. IR, SEM, XRD and other tests have shown that the functionalized magnetic chitosan microspheres have been successfully prepared and have good adsorption properties for methyl orange. At the same time, adsorption kinetics studies show that the functionalized magnetic chitosan microspheres are effective against methyl orange. The adsorption meets the quasi-two-rate model.

关键词： electron beam radiation Magnetism Chitosan Hydrogel Methyl orange

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