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Leveraging electrochemical sensors to improve efficiency of cancer detection

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World Journal of Clinical Oncology 2024年第3期15卷 360-366页

作者： Li Fu Hassan Karimi-Maleh College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018Zhejiang ProvinceChina School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731Sichuan ProvinceChina School of Engineering Lebanese American UniversityByblos 11022801Lebanon

electrochemical biosensors have emerged as a promising technology for cancer detection due to their high sensitivity,rapid response,low cost,and capability for non-invasive detection.Recent advances in nanomaterials like nanoparticles,graphene,and nanowires have enhanced sensor performance to allow for cancer biomarker detection,like circulating tumor cells,nucleic acids,proteins and metabolites,at ultra-low concentrations.However,several challenges need to be addressed before electrochemical biosensors can be clinically implemented.These include improving sensor selectivity in complex biological media,device miniaturization for implantable applications,integration with data analytics,handling biomarker variability,and navigating regulatory approval.This editorial critically examines the prospects of electrochemical biosensors for efficient,low-cost and minimally invasive cancer screening.We discuss recent developments in nanotechnology,microfabrication,electronics integration,multiplexing,and machine learning that can help realize the potential of these sensors.However,significant interdisciplinary efforts among researchers,clinicians,regulators and the healthcare industry are still needed to tackle limitations in selectivity,size constraints,data interpretation,biomarker validation,toxicity and commercial translation.With committed resources and pragmatic strategies,electrochemical biosensors could enable routine early cancer detection and dramatically reduce the global cancer burden.

关键词： electrochemical sensors Cancer biomarkers Nanomaterials Point-of-care diagnostics Microfabrication Machine learning

MXene-based electrochemical (bio) sensors for sustainable applications: Roadmap for future advanced materials

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Nano Materials Science 2023年第1期5卷 39-52页

作者： Qing Wang Ning Han Zhangfeng Shen Xue Li Zhijie Chen Yue Cao Weimeng Si Fagang Wang Bing-Jie Ni Vijay Kumar Thakur School of Material Science and Engineering Shandong University of TechnologyZibo255000China Department of Materials Engineering KU LeuvenLeuven3001Belgium College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing314001China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo255000China Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneyNSW2007Australia Biorefining and Advanced Materials Research Center SRUCEdinburghEH93JGUnited Kingdom School of Engineering University of Petroleum&Energy Studies(UPES)Dehradun248007UttarakhandIndia Centre for Research&Development Chandigarh UniversityMohali140413PunjabIndia

MXenes are emerging transition metal carbides and nitrides-based 2D conductive materials.They have found wide applications in sensors due to their excellent valuable properties.This paper reviews the recent research status of MXene-based electrochemical(bio)sensors for detecting biomarkers,pesticides,and other aspects.The first part of this paper introduced the synthesis strategy and the effect of surface modification on various prop-erties of MXenes.The second part of this paper discussed the application of MXenes as electrode modifiers for detecting pesticides,environmental pollutants,and biomarkers such as glucose,hydrogen peroxide,etc.Hope this review will inspire more efforts toward research on MXene-based sensors to meet the growing requirements.

关键词： MXenes electrochemical sensors Biomarkers Pesticides

A review on recent advances in hydrogen peroxide electrochemical sensors for applications in cell detection

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Chinese Chemical Letters 2022年第9期33卷 4133-4145页

作者： Yan Yu Meng Pan Jinrong Peng Danrong Hu Ying Hao Zhiyong Qian State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610065China

Hydrogen peroxide(H_(2)O_(2))is a very simple bioactive small molecule.In living organisms,H_(2)O_(2)plays an important role in intracellular signaling.It is involved in many physiological processes including cellular physiology,intracellular signaling,oxidative damage and disease progression.The tumor microenvironment enriched with H_(2)O_(2).Several electrochemical sensors have been developed and some have been put on the market.Such electrochemical sensors provide efficient,cost-effective,rapid and highly selective method of H_(2)O_(2)detection.So far,much progress has been made in the designing of materials and construction of H_(2)O_(2)sensors.This review describes the advances in the application of H_(2)O_(2)electrochemical sensors in cell detection.Enzyme-based sensors have been applied in diverse applications.In addition,recent advancements in nanotechnology have improved the development of nanozymes-based sensors.The application of noble metals,metal oxides,polymers,carbon materials and other two-dimensional materials in the design of H_(2)O_(2)sensors are discussed in detail.Moreover,the bio-stimulant types of H_(2)O_(2)sensor are summarized.Finally,the challenges and future perspectives in the application of H_(2)O_(2)electrochemical sensors in biological detection are discussed.

关键词： Hydrogen peroxide electrochemical sensors Cells detection Enzyme Nanozyme

Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition

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Rare Metals 2024年第1期43卷 225-235页

作者： Feng-Xia Wu Feng-Hua Li Xia-Li Lv Qi-Xian Zhang Guo-Bao Xu Wen-Xin Niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic activity.Recently,significant advance has been made in synthesizing metal nanocrystals with intrinsic chirality.Nonetheless,the majority reports are limited to gold.Herein,through a heteroepitaxial growth strategy,the synthesis of metal nanocrystals with intrinsic chirality to palladium was extended for the first time and their application in enantioselective recognition was demonstrated.The heteroepitaxial growth strategy allows for transferring the chirality of homochiral Au nanocrystals to Au@Pd core–shell nanocrystals.By employing the chiral Au@Pd nanocrystals as enantiomeric recognizing elements,a series of electrochemical sensors for chiral discrimination were developed.Under optimal conditions,the peak potential between D-dihydroxyphenylalanine(D-DOPA)and L-dihydroxyphenylalanine(L-DOPA)is about 80 m V,and the peak current of D-DOPA is 2 times as much as that of L-DOPA,which enables the determination of the enantiomeric excess(EE,%)of L-DOPA.Overall,this report not only introduces a heteroepitaxial growth strategy to synthesize metal nanocrystals with intrinsic chirality,but also demonstrates the superior capability of integrating intrinsic chirality and catalytic properties into metal nanocrystals for chiral recognition.

关键词： Core–shell nanostructures Chirality transfer electrochemical sensors Chiral recognition Chiroplasmonics

Universal synthesis of metallophthalocyanine covalent organic frameworks as ultra-sensitive multifaceted electrochemical sensor

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Science China Chemistry 2024年第6期67卷 2092-2101页

作者： Qi Liu Qiqi Sun Yuming Zhang Hao Li Wenmiao Chen Yuexing Zhang Sirong Yu Yanli Chen Jianzhuang Jiang School of Materials Science and Engineering China University of Petroleum(East China)Qingdao266580China Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing100083China College of Chemistry and Chemical Engineering Dezhou UniversityDezhou253023China

The universal synthesis of highly stable covalent organic frameworks(COFs)for ultra-sensitive and multi-component electrochemical detection in different scenarios remains a great challenge.Herein,a series of metallophthalocyanine-based twodimensional(2D)dioxin(DXI)-linked metalophthalocyanine(MPc)-n DXI-COFs(M=Ni,Zn;n=1,2)are afforded in high yield(80%-96%)by a facile trace-quinoline assisted one-pot condensation of tetracarbonitrile precursors.Powder X-ray diffraction and electron microscopy investigations disclose their lamellar texture 2D network with AA stacking mode.Experiments and calculation results elucidate that the 2DXI-linked MPc-2DXI-COFs provide the stronger built-in electronic field and more electrostatic/hydrogen bonding adsorption sites than DXI-linked MPc-DXI-COFs,and the lower electrode reaction Gibbs free energy and stronger adsorption of analytes at Ni Pc than Zn Pc unit,which grants Ni Pc-2DXI-COF excellent sensing properties for various analytes including neurotransmitters,organic pollutants,and heavy metal ions,with high sensitivity and low detection limit of 0.53 to 25.66 nM.Especially in binary and ternary systems and even in real-world conditions,simultaneous multi-component detection could be achieved.

关键词： covalent organic framework metallophthalocyanine 2D materials electrochemical sensors multi-component detection

A CMOS analog front-end chip for amperometric electrochemical sensors

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Journal of Semiconductors 2015年第7期36卷 124-129页

作者：李志超刘云涛陈敏肖璟博陈杰 Institute of Microelectronics Chinese Academy of Sciences College of Information and Communication Engineering Harbin Engineering University

This paper reports a complimentary metal-oxide-semiconductor （CMOS） analog front-end chip for amperometric electrochemical sensors. The chip includes a digital configuration circuit, which can communicate with an external microcontroller by employing an I^2C interface bus, and thus is highly programmable. Digital correlative double samples technique and an incremental sigma-delta analog to digital converter （∑-△ ADC） are employed to achieve a new proposed system architecture with double samples. The chip has been fabricated in a standard 0.18-μm CMOS process with high-precision and high-linearity performance occupying an area of 1.3 × 1.9 mm^2. Sample solutions with various phosphate concentrations have been detected with a step concentration of 0.01 mg/L.

关键词： CMOS analog front-end electrochemical sensors system-on-chip

electrochemical sensors;Strategies for Improving Selectivity and Sensitivity

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化学传感器 1997年第4期 244-245页

作者： Heineman WilliamR. University of Cincinnati Department of Chemistry P.O.Box210172 Cincinnati Ohio 45221-0172 U.S.A

One of the most difficult aspects of sensor development can be the achievement of adequate se-lectivity and sensitivity for the intended application. Thus, strategies for improving selectivityand sensitivity are important to the future of sensors, especially for applications invoiving thedetection of low concentrations of analytes in complicated sample matrices. Two examples ofthese strategies are electrochemical immunoassay and polymer--modified electrodes.

关键词： electrochemical sensors Strategies for Improving Selectivity and Sensitivity

Polyoxometalate-based metal-organic complexes constructed from a new bis-pyrimidine-amide ligand with high capacitance performance and selectivity for the detection of Cr(Ⅵ)

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Chinese Chemical Letters 2022年第9期33卷 4389-4394页

作者： Qianqian Liu Junjun Lu Hongyan Lin Xiuli Wang Zhihan Chang Yongzhen Chen Yuchen Zhang College of Chemistry and Materials Engineering Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar CellBohai UniversityJinzhou 121013China

In this paper,three new polyoxometalates(POM)-based metal–organic complexes constructed from a new semi-rigid organic ligand N,N'-bis(4-pyrimidinecarboxamido)-1,2-cyclohexane(4-bpmah)H_(2)[Cu(4-bpmah)_(2)(SiMo_(12)O_(40))(H_(2)O)_(2)]·2H_(2)O(1),H[Cu(4-bpmah)_(2)(PMo_(12)O_(4)0)(H_(2)O)_(2)]·2H_(2)O(2)and[Cu(4-bpmah)(H_(2)O)_(2)]·[Cu_(2)(TeMo_(6)O_(24))(H_(2)O)_(10)]·4H_(2)O(3)were synthesized by hydrothermal method.Single crystal X-ray analyses showed that complexes 1 and 2 were isostructural,in which the isolated Keggin-type[SiMo1_(2)O_(40)]^(4–)/[PMo_(12)O_(40)]^(3–)anions and[Cu(4-bpmah)_(2)(H_(2)O)2]^(2n+)units were expanded into 3D supramolecular structures through hydrogen bond interactions.In complex 3,the 1D[Cu(4-bpmah)(H_(2)O)_(2)]^(2n+)metal–organic chains and isolated[Cu_(2)(TeMo_(6)O_(24))(H_(2)O)_(10)]^(2n–)units were expanded into a 3D supramolecular framework by the hydrogen bond interactions.In this paper,carbon cloth working electrodes composited by the title complexes(1/CC,2/CC and 3/CC)were prepared and used as electrodes for supercapacitors.The performance of supercapacitors as well as the influence of electrolyte solution and title complexes quality load on the performance of supercapacitors were studied.Furthermore,the electrochemistry and electrocatalytic behaviors of complexes 1–3 bulk-modified carbon paste electrodes(1-CPE,2-CPE and 3-CPE)toward the reduction of KBrO_(3),KNO_(2),Cr(Ⅵ),as well as their sensing behaviors on Cr(Ⅵ)were investigated.

关键词： Polyoxometalates Metal–organic complexes Supercapacitor Electrocatalysis electrochemical sensors

Plasma functionalized MoSe2 for efficient nonenzymatic sensing of hydrogen peroxide in ultra-wide pH range

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SmartMat 2022年第3期3卷 491-502页

作者： Yang Luo Donghai Wu Zehui Li Xiao‐Yan Li Yinghong Wu Shien‐Ping Feng Carlo Menon Houyang Chen Paul K.Chu Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina Empa Swiss Federal Laboratories for Materials Science and TechnologyETH DomainDübendorfSwitzerland Centre for Water Technology and Policy Department of Civil EngineeringThe University of Hong KongHong KongChina Henan Key Laboratory of Nanocomposites and Applications Institute of Nanostructured Functional MaterialsHuanghe S&T UniversityZhengzhouChina State Key Laboratory for Mesoscopic Physics Collaborative Innovation Center of Quantum MatterSchool of PhysicsPeking UniversityBeijingChina Biomedical and Mobile Health Technology Lab Department of Health Sciences and TechnologyETH ZürichZürichSwitzerland Department of Mechanical Engineering The University of Hong KongHong KongChina Department of Chemical and Biological Engineering State University of New York at BuffaloNew YorkUSA

Enzymatic sensors have inherent problems such as the low stability and limited pH range in industrial and biomedical applications and therefore,more efficient nonenzymatic sensors are highly desirable.Herein,plasmafunctionalized defective MoSe_(2)is prepared and studied as a highly efficient catalyst for electrochemical sensing of H_(2)O_(2).Experiments and theoretical computations show that the plasma-induced Se multi-vacancies and nitrogen dopants generate new active sites,expose more edge active surfaces,narrow the bandgap,and strengthen binding with the·OH intermediate,which imparts new fundamental knowledge about the roles of defects in catalysis.The defective MoSe_(2)-catalyzed sensor delivers competitive performance in hydrogen peroxide detection such as a low detection limit of 12.6 nmol/L,wide operational pH range of 1−13,good long-term stability,and high selectivity.The portable sensor produced by screen printing confirms the excellent commercial potential and in addition,the results not only reveal a novel concept to design and fabricate high-performance sensors for H_(2)_(O2)but also provide insights into the effectiveness of surface modification of diverse catalytic materials.

关键词： MoSe_(2) plasma functionalization electrochemical sensors hydrogen peroxides portable devices