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RhIr@MoS2 nanohybrids based disposable microsensor for the point-of-care testing of NADH in real human serum

Chinese Chemical Letters 2020年第8期31卷 2115-2118页

作者： Dongqing Ji Zi Ying Yuan Zhang Wei Chen Metini Janyasupab Xinghua Gao Lingyan Feng Weijia Wen Materials Genome Institute Shanghai UniversityShanghai 200444China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences.Shanghai 200050China Department of Emergency Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Electronics Engineering King Mongkut's Institute of Technology LadkrabangBangkok 10520Thailand

Dihydronicotinamide adenine dinucleotide(NADH)is an important enzyme in all living cells,which is found to be abnormally expressed in cancer *** it is redox-active,an electrochemical detection method would be suitable for monitoring its concentration in biological *** we present a strategy for specific determination of NADH in real human serum by using RhIr@MoS2 nanohybrids based *** implement the protocol,RhIr nanocrysrals are in-situ grown onto MoS2 interlayers forming a nanohybrid structure(RhIr@MoS2).After being locally deposited on an electrochemical microsensor,it could be used for the analysis of *** developed RhIr@MoS2 nanohybrids based microsensor possesses the ability for analyzing NADH at the applied potential of 0.07 V(much lower than most reported values).The detection limit is evaluated as low as 1 nmol/L even in bovine serum albumin(BSA)*** addition,the sampling analysis of human serum from cancer patients and health controls shows that the microsensor displays good diagnostic sensitivity and specificity,illustrating that this developed detection technique is a relatively accurate method for measuring NADH in biological *** proposed electrochemical microsensor assay also owns the benefits of convenience,disposable and easy processing,which make it a great possibility for future point-of-care cancer diagnosis.

关键词： MoS2 Nanohybrid electrochemical microsensor Point-of-care(POC)test Cancer diagnosis

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