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electro-acupuncture for stat3 expression and nuclear translocation in hippocampal tissues of rats following cerebral ischemia/reperfusion

引用

Neural Regeneration Research 2006年第8期1卷 717-720页

作者： Lihong Kong1, Xiaoling Zeng1, Guojie Sun1, Shenghong Liu2 1Staff Room of acupuncture and Moxibustion, Department of acupuncture and Bone Injury, Hubei College of Traditional Chinese Medicine, Wuhan 430061, Hubei Province, China 2Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430061, Hubei Province, China Staff Room of acupuncture and Moxibustion Department of Acupuncture and Bone Injury Hubei College of Tradiational Chinese Medicine Wuhan 430061 Hubei Province China Tongji Medical College Huazhong University of Science and Technology Wuhan 430061 Hubei Province China

BACKGROUND: It has been found in recent years that stat3 widely distributes in nervous system, including hippocampal CA1-3 region, dentate gyrus and cerebral neocortex, etc. Ischemic brain injury can cause the release of some cytokines and growth factors, while electro-acupuncture may have multi-level, multi-channel and multi-target protective and interventional effects on ischemic brain injury. OBJECTIVE: To observe the effects of electro-acupuncture on stat3 expression and nuclear translocation in hippocampal CA1 region of rat models of brain ischemia/reperfusion. DESIGN: Randomized and controlled observation. SETTING: Staff Room of acupuncture and Moxibustion, Department of acupuncture and Bone Injury, Hubei College of Traditional Chinese Medicine; Tongji Medical College, Huazhong University of Science and Technology. MATERIALS: Seventy-two healthy SD rats, of clean degree and either gender, weighing (200±20) g, were provided by the Experimental Animal Center of Hubei College of Traditional Chinese Medicine. stat3 monoclonal antibody was purchased from Santa Cruz Company, USA, and G-6805 electro-acupuncture instrument was purchased from Shanghai Medical electronic Instruments Factory. METHODS: This experiment was carried out in the comprehensive laboratory of Department of acupuncture and Bone Injury, Hubei College of Traditional Chinese Medicine between September 2005 and February 2006. Seventy-two rats were randomly divided into 4 groups: ① control group(n =6): Untouched. ② Sham-operation group (n =18): Artery was isolated, but without inserting thread bolt.③ Model group (n =24): Rat models of local brain ischemia/reperfusion were established with modified suture occlusion. ④electro-acupuncture group (n =24): Dazhui and bilateral Neiguan points were selected for electro-acupuncture treatment. No. 28 acupuncture needle of 3.33 cm was used in the treatment. A G-6085 electro-acupuncture instrument with continuous wave, frequency of 120 times/min, intensity of 1 mA

关键词： stat electro-acupuncture for stat3 expression and nuclear translocation in hippocampal tissues of rats following cerebral ischemia/reperfusion

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