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Multifunctional hydrogel combined with electrical stimulation therapy for promoting diabetic wound healing

Nano Research 2024年第11期17卷 9942-9953页

作者： Xiaoyan Zheng Jiaxin Yao Jialing Yao Pan Wang Wan Liu Daidi Fan Junfeng Hui Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing Ministry of Education School of Chemical Engineering Northwest University Xi’an 710127 China Shaanxi Key Laboratory of Biomaterials and Synthetic Biology Shaanxi R & D Center of Biomaterials and Fermentation Engineering School of Chemical Engineering Northwest University Xi’an 710127 China Biotech. & Biomed. Research Institute Northwest University Xi’an 710127 China

Diabetic wounds, as a complication of diabetes, are slow to heal and seriously affect the quality of life of patients. Functional hydrogel dressing is an effective approach to improve diabetic wound healing. electrical stimulation (ES) therapy is conducive to promoting cell migration and wound healing. In this work, a multifunctional PPTZ hydrogel wound dressing was developed by freeze-thaw method with polyvinyl alcohol (PVA), phytic acid (PA), tannic acid (TA), and Zinc chloride. The obtained PPTZ hydrogel has good mechanical properties (stress and strain of 700.03 kPa and 575.08%), light transmittance (close to 100%) and antibacterial rate (over 75%). With good biocompatibility, antioxidant abilities and conductivity, the PPTZ hydrogel could effectively promote the healing of diabetic wounds with two weeks under the action of electric field, which provides an auxiliary treatment strategy for diabetic patients.

关键词： hydrogel dressing diabetic wound healing antibacterial antioxidant electrical stimulation therapy

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Non-invasive physical therapy as salvage measure for ischemic skin flap:A literature review

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World Journal of Clinical Cases 2021年第14期9卷 3227-3237页

作者： Yin-Hua Zheng Li-Quan Yin Hai-Kun Xu Xu Gong Department of Hand and Foot Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Rehabilitation Medicine The Third Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Radiology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

This review focuses on the available evidence regarding the molecular mechanisms and treatment potential of several non-surgical physical therapies for managing flap ischemia to propose a non-invasive,economical,and simple treatment to improve flap survival.A review of the literature was conducted on the topics of various non-invasive methods for the treatment of ischemic necrosis of the distal end of the flap between 1988 and 2019.A total of 52 published studies were reviewed on the applications of hyperbaric oxygen therapy,electrical stimulation therapy,heat stress pretreatment,phototherapy,and vibration therapy to manage skin flap *** underlying molecular mechanisms of these physical therapies on revitalizing the dying skin flaps were discussed and preliminary clinical uses of these therapies to salvage the necrotic skin flaps were pooled and summarized for clarifying the safety and feasibility of these *** physical therapy regimens have been ushered to manage necrotic development in cutaneous *** the refinement of these new technologies and enhancement of related basic science research on vascular revitalization,the prevention and treatment of flap ischemia will enter a new era.

关键词： Physiotherapy Skin flap Hyperbaric oxygen electrical stimulation therapy Heat stress pretreatment Phototherapy Vibration therapy

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Neuroplasticity in post-stroke gait recovery and noninvasive brain stimulation

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Neural Regeneration Research 2015年第12期10卷 2072-2080页

作者： Yi Xu Qing-hua Hou Shawn D.Russell Bradford C.Bennett Andrew J.Sellers Qiang Lin Dong-feng Huang Department of Rehabilitation Medicine the First Affiliated Hospital of Sun Yat-sen University Guangdong Provincial Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation Motion Analysis and Motor Performance Laboratory Department of Orthopedics and Mechanical EngineeringUniversity of Virginia Department of Neurology Guangdong No.2 Provincial People’s Hospital H.C Sweere Center for Clinical Biomechanics and Applied Ergonomics Northwestern Health Science University Department of Radiology Naval Medical Center Portsmouth

Gait disorders drastically affect the quality of life of stroke survivors,making post-stroke rehabilitation an important research *** brain stimulation has potential in facilitating neuroplasticity and improving post-stroke gait ***,a large inter-individual variability in the response to noninvasive brain stimulation interventions has been increasingly *** first review the neurophysiology of human gait and post-stroke neuroplasticity for gait recovery,and then discuss how noninvasive brain stimulation techniques could be utilized to enhance gait *** post-stroke neuroplasticity for gait recovery is characterized by use-dependent plasticity,it evolves over time,is idiosyncratic,and may develop maladaptive ***,noninvasive brain stimulation has limited reach capability and is facilitative-only in ***,we recommend that noninvasive brain stimulation be used adjunctively with rehabilitation training and other concurrent neuroplasticity facilitation ***,when noninvasive brain stimulation is applied for the rehabilitation of gait impairment in stroke survivors,stimulation montages should be customized according to the specific types of neuroplasticity found in each *** could be done using multiple mapping techniques.

关键词： nerve regeneration stroke cerebrovascular disorders transcranial magnetic stimulation neuroplasticity transcranial direct current stimulation electrical stimulation therapy gait walking gait disorders rehabilitation neural regeneration

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