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Prevaccination Antibody Confers Additional Immune Responses to Repeated Yearly Influenza Vaccination in an elderly Population

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World Journal of Vaccines 2022年第2期12卷 11-19页

作者： Satoko Kitamura Naoki Komatsu Masahide Matsushita Hiromi Seo Seisho Takeuchi Department of General Medicine Kochi Medical School Hospital Nankoku Japan Kochi General Rehabilitation Hospital Kochi Japan

Annual vaccination is necessary to maintain humoral immunity in the elderly population. However, the factors influencing the response to influenza vaccination have not been completely identified. The aim of this study was to explore the factors that influenced antibody responses to repeated vaccination using measures that were both objective and quantitative. A total of 111 volunteers aged > 61 years were vaccinated subcutaneously with one dose of influenza vaccine from the 2005-2006 season through the 2009-2010 season. The factors that influenced antibody responses after vaccination were evaluated. The seroprotection rates (PRs) were significantly higher in responders (subjects with a higher antibody titer in the 2005-2006 season) than in nonresponders only in the 2006-2007 and 2007-2008 seasons. PRs after vaccination were significantly higher in seropositive individuals (subjects with a higher prevaccination antibody titer in the 2006-2007 season) than in seronegative individuals for all three virus strains in almost all of the 5 years. Age, gender, and vaccination in the 2004-2005 season did not influence the response. These results suggest that an immune response at a certain time point would predict immune responses only in the near future. However, prevaccination antibody titer in the following season is the ideal predictor for future responses that last over several influenza seasons.

关键词： Influenza Vaccine elderly persons Repeated Vaccination Seroprotection Rate

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Epidemiological investigation of Helicobacter pylori infection in elderly people in Beijing

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World Journal of Clinical Cases 2020年第11期8卷 2173-2180页

作者： Hong-Ming Zhu Bang-Yi Li Zhe Tang Jing She Xue-Ying Liang Li-Kou Dong Mei Zhang Department of Gastroenterology Xuanwu HospitalCapital Medical UniversityBeijing 100053China National Geriatric Disease Clinical Medical Research Center Xuanwu HospitalBeijing 100053China

BACKGROUND The Helicobacter pylori(***)infection rate in China is approximately 50%.*** is a pathogenic factor of peptic ulcer and chronic *** addition,*** infection may also be associated with a variety of cardiovascular diseases in elderly people,such as arteriosclerosis,coronary heart disease,and cerebral infarction,having deleterious effect on their *** the aging of the population,the disease characteristics of the elderly population have been increasingly valued by the whole *** conducted an epidemiological survey of *** infection among elderly people in Beijing to provide a basis for health management of *** *** To understand the epidemiological characteristics of *** infection in elderly people in *** A total of 1090 elderly people aged more than 60 years from different parts of Beijing(urban and rural areas)were selected using the random cluster sampling *** questionnaires were completed during home visits and the 13C-urea breath test was conducted for *** *** The prevalence of *** infection was 46.5%(507/1090).The infection rate in men was 51.8%,which was significantly higher than that in women(42.5%;Ppersons(53.5%vs 44.8%,Pelderly people is 46.5%and the infection rate gradually increases with ***,education level,age,and smoking were determined to be *** infection risk *** relationship of *** infection with region,occupation,drinking,and diet structure needs to be further studied.

关键词： Helicobacter pylori Epidemiologic elderly persons 13C-urea breath test Prevalence Characteristics

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