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Wet environment-induced adhesion and softening of coenzyme-based polymer elastic patch for treating periodontitis

Bioactive Materials 2024年第5期35卷 259-273页

作者： Ying Qi Chenyu Xu Zhuodan Zhang Qian Zhang Ziyang Xu Xinrui Zhao Yanhong Zhao Chunyan Cui Wenguang Liu School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China School and Hospital of Stomatology Department of OrthodonticsTianjin Medical UniversityTianjin300070China

Periodontitis,a common chronic inflammatory disease caused by pathogenic bacteria,can be treated with diverse biomaterials by loading drugs,cytokines or ***,these biomaterials often show unsatisfactory therapeutic efficiency due to their poor adhesion,short residence time in the wet and dynamic oral cavity and emerging drug *** we report a wet-responsive methacrylated gelatin(GelMA)-stabilized co-enzyme polymer poly(α-lipoic acid)(PolyLA)-based elastic patch with water-induced adhesion and softening *** PolyLA-GelMA,the multiple covalent and hydrogen-bonding crosslinking between PolyLA and GelMA prevent PolyLA depolymerization and slow down the dissociation of PolyLA in water,allowing durable adhesion to oral periodontal tissue and continuous release of LA-based bioactive small molecule in periodontitis wound without resorting external *** with the undifferentiated adhesion behavior of traditional adhesives,this wet-responsive patch demonstrates a favorable periodontal pocket insertion ability due to its non-adhesion and rigidity in dry *** vitro studies reveal that PolyLA-GelMA patch exhibits satisfactory wet tissue adhesion,antibacterial,blood compatibility and ROS scavenging *** the model of rat periodontitis,the PolyLA-GelMA patch inhibits alveolar bone resorption and accelerates the periodontitis healing by regulating the inflammatory *** biomacromolecule-stabilized coenzyme polymer patch provides a new option to promote periodontitis treatment.

关键词： Co-enzyme α-Lipoic acid Wet tissue adhesion elastic patch Periodontitis

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