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Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

Journal of Pharmaceutical Analysis 2020年第4期10卷 277-290页

作者： Armel Jackson Seukep Victor Kuete Lutfun Nahar Satyajit DSarker Mingquan Guo Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanChina Sino-Africa Joint Research Center Chinese Academy of SciencesWuhanChina Unit of Research in Microbiology and Antimicrobial Substances/Laboratory of Cancer Research Faculty of ScienceDepartment of BiochemistryUniversity of DschangDschangCameroon Laboratory of Growth Regulators Institute of Experimental Botany ASCR&PalackýUniversitySlechtitelu 2778371OlomoucCzech Republic Centre for Natural Products Discovery School of Pharmacy and Biomolecular SciencesLiverpool John Moores UniversityLiverpoolL33AFUnited Kingdom

The upsurge of multiple drug resistance(MDR)bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic *** major factor in MDR is efflux pump-mediated resistance.A unique pump can make bacteria withstand a wide range of structurally diverse ***,their inhibition is a promising route to eliminate resistance phenomenon in *** are excellent alternatives as resistance-modifying *** can directly kill bacteria or interact with the crucial events of pathogenicity,thereby decreasing the ability of bacteria to develop *** botanicals display noteworthy efflux pumps inhibitory *** plants are of growing ***,some plant families would be excellent sources of efflux pump inhibitors(EPIs)including Apocynaceae,Berberidaceae,Convolvulaceae,Cucurbitaceae,Fabaceae,Lamiaceae,and *** applicable methods for screening plant-derived EPIs include checkerboard synergy test,berberine uptake assay and ethidium bromide *** silico highthroughput virtual detection can be evaluated as a criterion of excluding compounds with efflux substrate-like characteristics,thereby improving the selection process and extending the identification of *** ascertain the efflux activity inhibition,real-time PCR and quantitative mass spectrometry can be *** review emphasizes on efflux pumps and their roles in transmitting bacterial resistance and an update plant-derived EPIs and strategies for identification.

关键词： Multidrug-resistant bacteria Efflux pump inhibitors Plant secondary metabolites edible plants Efflux activity assays

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Profile Differences of Trace Elements in Vegetables and Fruits Resulting from Various Digestion Procedures

Profile Differences of Trace Elements in Vegetables and Frui...

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2011 International Conference on New Technology of Agricultural Engineering(ICAE 2011)

作者： Sun Chang-xia Laboratory of Agricultural Analysis TianJin Agriculture University TianJin P.R.China Wei Dong-sheng 3Division of Wood Biology Department of Wood Science Faculty of Mathematics Informatics and Natural Sciences Germany Liu Hai-xue Laboratory of Agricultural Analysis TianJin Agriculture University TianJin P.R.China Huang Liang Department of Agronomy TianJin Agriculture University TianJin P.R.China Zhang Bo-lin College of Biological Science and Biotechnology BeiJing Forestry University BeiJing P.R.China Wu Cheng-liang College of Economics and Management BeiJing Forestry University BeiJing P.R.China

Three pre-treatments of dry ashing,wet ashing and microwave digestion procedures in flame atomic absorption spectrometry（FAAS）,were investigated to evaluate their effects on the concentrations of trace elements including Cu,Zn,Fe and Mn for edible plant *** was proved to be a good digestion method in the present study due to shorter time,better recoveries and low relative standard deviations（RSDs）.For the certified reference materials,RSDs were below 10%and the recovery values of Cu,Zn,Fe and Mn were from 96.63%to 100.00%when microwave digestion procedure was used for *** trace elements contents were detected when microwave digestion instead of the other digestion methods was chosen to pre-treat spinach or apple *** values of the addition recovery in the studied trace elements of Chinese chive or lettuce ranged from 97.00%to 100.00%due to the use of microwave digestion ***,the use of microwave digestion to pre-treat edible plant samples improved the determination accuracy of trace elements in food nutrition assay and concentrations of Cu,Zn,Fe and Mn in investigated edible plants were acceptable to human consumption at nutritional and toxic levels.

关键词： trace elements FAAS edible plants microwave digestion procedure

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