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ectopic atp synthase in endothelial cells:a novel cardiovascular therapeutic target

岭南心血管病杂志 2011年第S1期17卷 35-36页

作者： Yi Zhu (Department of Physiology and Pathophysiology, Peking University Health Science Center,Beijing 100191,China)

atp synthase(atpS) produces atp in cells and is found on the inner membrane of mitochondria or the cell plasma *** this presentation, we will briefly summarize the functions of ecto-atpS in vascular endothelial cells(ECs).Ecto -atpS is involved in adenosine metabolism on the cell surface through its atp generation or hydrolysis *** atp/ADP generated by the enzyme on the plasma membrane can bind to P2X/P2Y receptors and activate the related signaling pathways to regulate endothelial ***-chain of ectopic atp synthase(atpS) on the EC surface can recruit inflammatory cells and activate cytotoxic activity to damage ECs and induce vascular *** and other angiogenesis inhibitors can have anti-angiogenic functions by inhibiting ecto-atpS on ***-atpS on ECs is also a receptor for apoA-Ⅰ, the acceptor of cholesterol efflux,which implies the involvement in cholesterol *** main talk will focus on our recent study about shear stress regulated membrane translocation of atpS in ECs and the consequent interaction with T lymphocytes, which caused endothelial *** found that laminar flow decreased level of membrane-bound atpS(ecto-atpS) and depleted membrane cholesterol level in *** contract,oscillatory flow increased endothelial ecto-atpS? and membrane cholesterol *** ECs with cholesterol or depleting cellular cholesterol could mimic the effect of oscillatory or laminar flow,*** of caveolin-1 expression by siRNA prevented atpS translocation in response to shear ***, oscillatory flow elevated the number of T cells binding to ECs,and effect that could be blocked by anti-atpS antibody;laminar flow significantly decreased this ***,the interaction of T cells and atpS membrane translocation was elevated in the inner curvature of the aortic arch of apoE-/- mice fed a high-fat diet. Thus,our study provided the first evidence that disturbed flow and hyp

关键词： atpS ectopic atp synthase in endothelial cells

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