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WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Purinergic receptors and nucleotide processing ectoenzymes:Their roles in regulating mesenchymal stem cell functions

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World Journal of Stem Cells 2014年第2期6卷 153-162页

作者： Sonia Scarfì Department of Earth Environment and Life SciencesUniversity of Genova

Human mesenchymal stem cells(MSCs)are a rare population of non-hematopoietic stem cells with multilineage potential,originally identified in the bone *** to the lack of a single specific marker,MSCs can be recognized and isolated by a series of features such as plastic adherence,a panel of surface markers,the clonogenic and the differentiation *** recognized role of MSCs in the regulation of hemopoiesis,in cell-degeneration protection and in the homeostasis of mesodermal tissues through their differentiation properties,justifies the current interest in identifying the biochemical signals produced by MSCs and their active crosstalk in tissue *** recently have extracellular nucleotides(eNTPs)and their metabolites been included among the molecular signals produced by *** molecules are active on both ionotropic and metabotropic receptors present in most cell *** possess a significant display of these receptors and of nucleotide processing ectoenzymes on their plasma ***,from their niche,MSCs give a significant contribution to the complex signaling network of eNTPs and its *** studies have demonstrated the multifaceted aspects of eNTP metabolism and their signal transduction in MSCs and revealed important roles in specifying differentiation lineages and modulating MSC physiology and communication with other *** review discusses the roles of eNTPs,their receptors and ectoenzymes,and the relevance of the signaling network and MSC functions,and also focuses on the importance of this emerging area of interest for future MSC-based cell therapies.

关键词： Mesenchymal stem cell Purinergic receptors ectoenzymes ATP β-NAD Adenosine cADPR

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