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Anti-schistosomal activities of echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice

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Asian Pacific Journal of Tropical Medicine 2018年第10期11卷 570-575页

作者： Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman School of Medical Laboratory Sciences Jimma University School of Veterinary Medicine Jimma University School of Pharmacy Jimma University

Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of echinops kebericho Mesfin(E. kebericho) root and Hagenia abyssinica(Bruce) J.F. Gmel(H. abyssinica) flower. Methods: Mice were infected with(150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1 200 mg/kg/day along with 200 mg/kg/day praziquantel and 3% tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant(P < 0.05) reduction in fecal egg count of 64.44%, 42.96% & 26.82% and worm burden of 65.71%, 47.86% & 31.43% at treatment doses of 1 200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant(P < 0.05) reduction in fecal egg count up to 84.57%, 77.06% & 63.89% and worm burden of 91.43%, 81.43% & 70.71% at a respective dose levels. In addition, a significant(P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1 200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity.

关键词： Schistosoma mansoni echinops kebericho Hagenia abyssinica Crude extract Antischistosomal activity Ethiopia

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Assessment of microwave assisted and hydrodistllation extraction on echinops persicus essential oils chemical composition and evaluation of its biological activity

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Traditional Medicine Research 2019年第5期4卷 246-256页

作者： Maryam Soori Hossein Abbaspour Hamid Hashemi-Moghaddam Department of Biology Damghan Branch Islamic Azad University Damghan *** Iran Department of Chemistry Damghan Branch Islamic Azad University Damghan *** Iran

Background: E. persicus which is well-known as Shakarook in local Persian botany and is extensively utilized in different parts of in Iran. Materials and methods: Essential oils from the aerial parts of echinops persicus were isolated using hydrodistillation (HD) and microwave assisted hydrodistillation (MAHD) methods and the respective chemical profiles were analyzed by means of GC-MS technique. The in vitro antioxidant and antimicrobial activities of methanol extracts of E. persicus were investigated via using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) assay as well as agar well-diffusion methods. The minimun inhibitory concentrations (MICs) of the methanol extracts of E. persicus against the test microorganisms were determined by the broth microdilution method. Results: GC-MS essential oils analysis shows 29 and 36 compounds constituting 91.9% and 98.2% of the total oils using HD and MAHD methods, respectively. Furthermore, the methanol extracts of E. persicus exhibited higher DPPH radical scavenging activity than vitamin C with an IC50 value of 0.42 ± 0.16 μg/mL. Moreover, the prepared methanol extracts preliminarily showed promising antimicrobial activities against S. aureus with the MIC value of 6.2 mg/mL. Conclusion: This study confirms that the methanol extract of E. persicus plant exhibits considerable antioxidant and antimicrobial properties in vitro.

关键词： echinops persicus Essential oil Methanol extracts Antioxidation Antimicrobial

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Micropropagation of Kebericho: An Endandered Ethiopian Medicinal Plant

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American Journal of Plant Sciences 2014年第26期5卷 3836-3847页

作者： Begashaw Manahlie Tileye Feyissa Department of Forestry Wondo Genet College of Forestry and Natural Resource Hawassa University Shashemene Ethiopia Institute of Biotechnology Addis Ababa University Addis Ababa Ethiopia

echinops kebericho, endemic to Ethiopia, is a critically endangered medicinal plant. It is among the most important medicinal plants of the country, valued primarily for its root parts. The commercial harvesting and sale of roots of E. kebericho have threatened local populations. This study aimed to develop micropropagation protocol for E. kebericho using shoot tip explants. The study started with seed germination test using seeds stored for different months. Shoot tips from in vitro germinated seedlings were cultured on shoot initiation MS media supplemented with 0, 0.1, 0.5, 1.0, 1.5 and 2.0 mg/l BAP or KN alone. Explants were cultured on shoot proliferation media fortified with Kinetin, BAP, and TDZ each at 0.0, 0.5, 1.0, 2.5, 3.0 and 5.0 mg/l either alone or in combination with 0.0, 0.1, 0.25 and 0.5 mg/l NAA. For rooting, full, half and 1/3 strength MS media supplemented with IBA and NAA alone each at 0, 0.05, 0.1, 0.5, 1.0, 1.5 and 2.5 mg/l were used. Growth regulator free MS medium was used as control. Study results showed that 100% germination was recorded in fresh seeds and dropped as low as 65.18% and 22.3% for 3 and 5 months seeds respectively. 1.0 mg/l KN and 0.5 mg/l KN + 0.1 mg/l NAA showed maximum shoot proliferation on shoot induction media and shoot multiplication media respectively. Best rooting was obtained on 1/3 MS containing 1.5 mg/l NAA with 8.23 roots and 4.82 cm root length and established under greenhouse with 83% survival.

关键词： echinops kebericho Micropropagation Shoot Tip Plant Growth Regulator

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