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EDdb:A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder

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Science China(Life Sciences) 2013年第11期56卷 1086-1096页

作者： ZHAO Min LI XiaoMo QU Hong Center for Bioinformatics State Key Laboratory of Protein and Plant Gene ResearchCollege of Life SciencesPeking University

eating disorder is a group of physiological and psychological disorders affecting approximately 1% of the female population worldwide. Although the genetic epidemiology of eating disorder is becoming increasingly clear with accumulated studies, the underlying molecular mechanisms are still unclear. Recently, integration of various high-throughput data expanded the range of candidate genes and started to generate hypotheses for understanding potential pathogenesis in complex diseases. This article presents EDdb （eating disorder database）, the first evidence-based gene resource for eating disorder. Fifty-nine experimentally validated genes from the literature in relation to eating disorder were collected as the core dataset. Another four datasets with 2824 candidate genes across 601 genome regions were expanded based on the core dataset using different criteria （e.g., protein-protein interactions, shared cytobands, and related complex diseases）. Based on human protein-protein interaction data, we reconstructed a potential molecular sub-network related to eating disorder. Furthermore, with an integrative pathway enrichment analysis of genes in EDdb, we identified an extended adipocytokine signaling pathway in eating disorder. Three genes in EDdb （AD1PO （adiponectin）, TNF （tumor necrosis factor） and NR3C1 （nuclear receptor subfamily 3, group C, mem- ber 1）） link the KEGG （Kyoto Encyclopedia of Genes and Genomes）＂adipocytokine signaling pathway＂ with the BioCarta ＂visceral fat deposits and the metabolic syndrome＂ pathway to form a joint pathway. In total, the joint pathway contains 43 genes, among which 39 genes are related to eating disorder. As the first comprehensive gene resource for eating disorder, EDdb （http：//***） enables the exploration of gene-disease relationships and cross-talk mechanisms between related disorders. Through pathway statistical studies, we revealed that abnormal body weight caused by eating disorder and obesity may both be rela

关键词： eating disorder database adipocytokine signaling pathway pathway analysis

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disordered eating behaviour and eating disorder among adolescents with type 1 diabetes:An integrative review

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World Journal of Meta-Analysis 2022年第5期10卷 244-254页

作者： Maria Conceição Santos Oliveira Cunha Francisco Clécio Silva Dutra Laura Martins Mendes Cavaleiro Brito Rejane Ferreira Costa Maria Wendiane Gueiros Gaspar Danilo Ferreira Sousa Márcio Flávio Moura deAraújo Maria Veraci Oliveira Queiroz Department of Nursing West Princess CollegeCrateús 63700-190CearáBrazil Department of Nursing Ceara State UniversityFortaleza 60714-903CearáBrazil Department of Health Family Oswaldo Cruz FoundationEusébio 61773-272CearáBrazil Department of Health Science University for the International Integration of Afro-Brazilian LusophonyRedenção 62790-000CearáBrazil Department of Nursing University for the International Integration of Afro-Brazilian LusophonyRedenção 62790-000Brazil

BACKGROUND Type 1 diabetes(DT1)in adolescents brings behavioural changes,altered nutritional habits,and eating *** To identify and analyze the validated instruments that examine the disordered eating behaviour and eating disorders among adolescents with *** An integrative review was accomplished based on the following databases:PubMed,LILACS,CINAHL,Scopus,Web of Science,and Reference Citation Analysis(RCA),including publications in Portuguese,English,or Spanish,without time limit and time *** The main instruments to evaluate disordered eating behaviour were The Diabetes eating Problem Survey-Revised,The Diabetes eating Problem Survey,and the eating attitudes test-26,and for eating disorders the main instruments used were The Bulimic Investigation Test of Edinburgh,The Binge eating Scale,The Child eating disorder Examination,The five questions of the(Sick,Control,One,Fat and Food),and The Mind Youth *** instruments showed an effect in evaluating risks regarding nutritional habits or feeding grievances,with outcomes related to weight control,inadequate use of insulin,and glycaemia *** did not identify publication *** Around the world,the most used scale to study the risk of disordered eating behaviour or eating disorder is The Diabetes eating Problem *** researchers use this scale to identify high scores in adolescents with DT1 and a relationship with poorer glycemic control and psychological problems related to body image.

关键词： Adolescent Type 1 diabetes mellitus Validation studies Nutritional behaviour eating disorder Review

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Characteristics and outcomes of avoidant/restrictive food intake disorder in Japanese elementary-school students on total parenteral nutrition

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Pediatric Investigation 2021年第4期5卷 293-298页

作者： Akira Tamura Koichi Minami Yuko Tsuda Hiroshi Tsujimoto Takayuki Ichikawa Kazuhiro Mizumoto Hiroyuki Suzuki Department of Pediatrics Wakayama Medical UniversityWakayama CityWakayamaJapan Department of Medical Safety Promotion Wakayama Medical UniversityWakayama CityWakayamaJapan

The clinical outcomes of adolescents with avoidant/restrictive food intake disorder(ARFID)remain ***,no report has compared the characteristics of ARFID and restricting-type anorexia nervosa(R-AN)in elementary-school students on total parenteral nutrition(TPN).This study retrospectively reviewed inpatients diagnosed with ARFID or R-AN between 2005 and *** with ARFID(two boys and seven girls)and R-AN(13 girls)were hospitalized because of rapid physical deterioration,and nutrition therapy was continued without *** ARFID group exhibited significantly lower body weights at admission than the R-AN group and gained an average of 6.5 kg during hospitalization;furthermore,the monthly weight gain during hospitalization was significantly higher,and no relapse was *** physical improvement in ARFID resulted in good *** conclusion,TPN can be easily introduced to patients with ARFID,in whom aversive eating is a concern,and is a suitable treatment for ARFID.

关键词： Adolescent Anorexia nervosa Avoidant/restrictive food intake disorder eating disorder Total parenteral nutrition

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