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early surgical intervention for structural infantile spasms in two patients under 6 months old:a case report

Acta Epileptologica 2020年第1期2卷 145-150页

作者： Haiyan Yang Zhiquan Yang Jing Peng Yehong Huang Zhuanyi Yang Fei Yin Liwen Wu Department of Pediatrics Xiangya HospitalCentral South UniversityChangsha 410008China. Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China. Department of Neurology Hunan Children’s HospitalChangsha 410007China.

Background:Infantile spasms(IS)are the most common childhood epileptic *** cortical dysplasia(FCD)and gray matter heterotopias(GH)are common structural causes of *** recommended first-line treatment for IS patients with structural causes is surgical intervention,according to the International League Against Epilepsy(ILAE)commission ***,there is currently no consensus on appropriate timings of *** presentations:Two structural IS cases are presented here:one was caused by FCD,and the other by *** patients exhibited recurrent seizures at the age of 2 months,had poor responses to various antiepileptic drugs(AEDs)and displayed severe mental and motor developmental *** types included focal seizures and *** magnetic resonance imaging showed abnormal gray signal or suspicious FCD lesions that coincided with the origin of the focal *** patients underwent lesion resection before the age of 6 ***-up observation showed that seizures of both patients were completely controlled several days after the *** AEDs were gradually reduced in dosage within 1 year,and the mental and motor development almost returned to ***:early resection of lesions in structural IS patients has benefits of effectively controlling convulsions and improving developmental *** at several months of age can well tolerate craniotomy,and their cognitive development is more likely to return to normal after early surgery.

关键词： Infantile spasms Focal cortical dysplasia Gray matter heterotopias early lesion resection

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