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Comparison of isolated-check visual evoked potential and standard automated perimetry in early glaucoma and high-risk ocular hypertension

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 599-604页

作者： Xiang-Wu Chen Ying-Xi Zhao Department of Outpatient Service the Eye Hospital of Wenzhou Medical University

AIM：To compare the diagnostic performance of isolatedcheck visual evoked potential（ic VEP） and standard automated perimetry（SAP）,for evaluating the application values of ic VEP in the detection of early ***：Totally 144 subjects（288 eyes） were enrolled in this *** VEP testing was performed with the Neucodia visual electrophysiological diagnostic system.A 15% positive-contrast（bright） condition pattern was used in this device to differentiate between glaucoma patients and healthy control ***-to-noise ratios（SNR） were derived based on a multivariate *** eyes were judged as abnormal if the test yielded an SNR≤*** testing was performed with the Humphrey Field Analyzer *** visual fields were deemed as abnormality if the glaucoma hemifield test results outside normal limits;or the pattern standard deviation with P〈0.05;or the cluster of three or more non-edge points on the pattern deviation plot in a single hemifield with P〈0.05,one of which must have a P〈*** photographs were graded as either glaucomatous optic neuropathy or normal by two experts who were masked to all other patient *** regression analysis（MRA） used as a separate diagnostic classification was performed by Heidelberg retina tomograph（HRT）.RESULTS：When the disc photograph grader was used as diagnostic standard,the sensitivity for SAP and ic VEP was 32.3% and 38.5% respectively and specificity was 82.3% and 77.8% *** the MRA Classifier was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 48.6% and 51.4% respectively and specificity was 84.1% and 78.0% *** the combined structural assessment was used as the diagnostic standard,the sensitivity for SAP and ic VEP was 59.2%and 53.1% respectively and specificity was 84.2% and 84.6% *** was no statistical significance between the sensitivity or specificity of SAP and ic VEP,regardless of which diagnostic standard was based ***

关键词： isolated-check visual evoked potential standard automated perimetry signal-to-noise ratios early glaucoma

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Utility of combining spectral domain optical coherence tomography structural parameters for the diagnosis of early glaucoma: a mini-review

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Eye and Vision 2018年第1期5卷 91-101页

作者： Jean-Claude Mwanza Joshua L.Warren Donald L.Budenz Department of Ophthalmology School of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA Department of Biostatistics Yale UniversityNew HavenCTUSA

Optical coherence tomography(OCT)has moved to the forefront of imaging modalities in the management of glaucoma and retinal *** is modifying how glaucoma and glaucoma progression are diagnosed clinically and augmenting our understanding of the *** provides multiple parameters from various anatomic areas for glaucoma diagnosis,evaluation of treatment efficacy,and progression *** the use of multiple parameters has increased the likelihood of detecting early structural changes,diagnosing glaucoma in early stages is often challenging when the damages are subtle and not apparent on OCT scans,in addition to the fact that assessment of OCT parameters often yields conflicting *** promising approach is to combine multiple individual parameters into a composite parameter from the same test to improve diagnostic accuracy,sensitivity,and *** review presents current evidence regarding the value of spectral domain OCT composite parameters in diagnosing early glaucoma.

关键词： Optical coherence tomography Combination of parameters early glaucoma

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