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Typology and Etiology of Precocious puberty in Sub-Saharan Africa:Report of 8 Cases in Abidjan,Ivory Coast

Advances in Sexual Medicine 2017年第4期7卷 161-166页

作者： Jacko R.Abodo Laurette Agbré-Yacé Adélaide Hué Ténédia Soro-Coulibaly Micondo Kouamé Mamadou Sanogo Jocelyne Danho Jean B.Ahoussi Adrien Lokrou Department of Endocrinology-Diabetology University Hospital YopougonAbidjanCote d’Ivoire Pediatric Endocrinology Unit National Institute of Public HealthAbidjanCote d’Ivoire Department of Pediatrics General Hospital of Abobo NordAbidjanCote d’Ivoire Pediatric Service Military Hospital of AbidjanAbidjanCote d’Ivoire

Introduction: early puberty is defined by development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. In the West, one in five children out of 100,000 is concerned. Little information on sub-Saharan African patients exists concerning this pathology. Objective: To determine the etiology and clinical characteristics of early puberty in a cohort of Ivorian children. Methods: We conducted a cross-sectional study between 2015 and 2017 in children admitted to early puberty in the unique Endocrinology Service of the country. The epidemiology and clinical characteristics were assessed. Results: The eight patients involved were all females. Their mean age at diagnosis was 7 years and 3 months and the mean age of first symptoms begun at 5 years and 6 months. Seven patients had a central precocious puberty (CPP) including five cases of idiopathic CPP (ICPP) treated by (GnRH agonist) and two cases with secondary precocious puberty (SPP). One of them has a hypothalamic hamartoma and the other a sequelae of encephalopathy. The last case had a peripheral precocious puberty (PPP) causes by ovarian dystrophy. Conclusion: Our results confirm the predominance of idiopathic central precocious puberty particularly in girls.

关键词： early puberty Secondary Sexual Characteristics Stature

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Premature puberty Revealing an Ovarian Tumor in a Five-Year-Old Girl

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Open Journal of Pediatrics 2023年第2期13卷 153-157页

作者： Senkaye-Lagom Aimée Kissou Yacouba Traoré Oumar Ganamé Aïda Traoré/Tankoano Mariane Kabré Emile Bandré Departement of Pediatrics CHU Sourô SANOU (CHUSS) Bobo-Dioulasso Burkina Faso Higher Institute of Health Sciences (INSSA) Nazi Boni University (UNB) Bobo-Dioulasso Burkina Faso Pediatric Surgery Service CHUSS Bobo-Dioulasso Burkina Faso Medical Imaging Service CHUSS Bobo-Dioulasso Burkina Faso Anatomical Pathology Service CHU-YO Bobo-Dioulasso Burkina Faso

Background: Ovarian tumors in the girl child are sometimes revealed by the development of secondary sexual characteristics. The authors report the case of a five-year-old girl in whom the disease was revealed by early puberty. Case presentation: A five-year-old girl with an enlarged abdomen for about four months. The onset of pain and the sensation of a mass prompted the consultation. The development of secondary sexual characteristics (SSC) noted by the family had not been mentioned. The patient was classified as pubertal stage 2 according to the Tanner classification. An abdominal ultrasound and a CT scan showed a large left ovarian mass, an enlarged uterus for the patient’s age and a normal right ovary. The hormonal workup was not contributive. The treatment consisted only of a left salpingo-ovarectomy, without complementary chemotherapy. Anatomic pathological examination of the surgical specimen concluded to a juvenile tumor of the granulosa. The evolution was good with a beginning of regression of the HSC one month after the ovarectomy. Discussion: Granulosa tumors are sometimes secretory cancers, generally with a low potential for malignancy and therefore a very good prognosis. Surgery based on total adnexectomy is the first-line treatment. The large size of the tumor, the presence of ascites and capsular rupture are factors of poor prognosis, hence the importance of early diagnosis. Conclusion: Routine comprehensive physical examination should be de rigueur for abdominal masses in girls, especially in the context of various beliefs that may impede early referral to care.

关键词： Ovarian Tumor Juvenile Granulosa Tumor early puberty early Diagnosis Surgery

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