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Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting era to inhibit RANKL signaling

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Acta Pharmaceutica Sinica B 2021年第2期11卷 442-455页

作者： Keqi Wang Yongyan Chen Shuo Gao Maosi Wang Mengmeng Ge Qian Yang Mingkai Liao Lin Xu Junjie Chen Zhiping Zeng Haifeng Chen Xiao-kun Zhang Ting Lin Hu Zhou School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchXiamen UniversityXiamen 361102China High Throughput Drug Screening Platform Xiamen UniversityXiamen 361102China

Although different types of drugs are available for postmenopausal osteoporosis,the limitations of the current therapies including drug resistances and adverse effects require identification of novel anti-osteoporosis ***,we defined that norlichexanthone(NOR),a natural product,is a ligand of estrogen receptor-alpha(ERα)and revealed its therapeutic potential for postmenopausal *** used mammalian-one hybrid assay to screen for ERαmodulators from crude extracts of several plant *** a result,NOR purified from the extract of endophyte ARL-13 was identified as a selective ERα*** directly bound to ERαwith an affinity in nanomolar range,revealing that it is a natural ligand of ERα.NOR induced osteoblast formation in MC3T3-E1 precursor ***,NOR inhibited receptor activator of nuclear factor-kappa B ligand(RANKL)-induced osteoclast formation in both RAW264.7 macrophages and mouse primary ***,NOR inhibited RANKL-induced association of ERαand TRAF6 to prevent ERα-mediated TRAF6 activation via Lys63-linked ***,NOR exhibited potent anti-osteoporosis efficacy in an ovariectomized mouse *** to estrogen,NOR was of much less capability in stimulating endometrial hyperplasia and promoting mammalian cancer cell *** together,our study identified NOR as a natural and high affinity ligand of ERαwith substantial anti-osteoporosis but less estrogenic activity.

关键词： Norlichexanthone Osteoporosis Osteoclast RANKL signaling TRAF6 era

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The era of Immune Checkpoint Therapy: From Cancer to Viral Infection——A Mini Comment on the 2018 Medicine Nobel Prize

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Virologica Sinica 2018年第6期33卷 467-471页

作者： Jia Liu Wen Pan Dongliang Yang Department of Infectious Diseases Union Hospital TongjiMedical College Huazhong University of Science and Technology

The 2018 Medicine Nobel Prize was awarded jointly to two immunologists, James P. Allison at the University of Texas MD Anderson Cancer Center in Houston and Tasuku Honjo at Kyoto University in Japan, who pioneered a n... 详细信息

关键词： PD In The era of Immune Checkpoint Therapy A Mini Comment on the 2018 Medicine Nobel Prize

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Delineation of Nitrogen Signaling Networks: Computational Approaches in the Big Data era

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Molecular Plant 2019年第2期12卷 150-152页

作者： Yoshiaki Ueda Shuichi Yanagisawa BiotechnologyResearchCenter TheUniversityofTokyoYayoi1-1-1Bunkyo-kuTokyo113-8657Japan

Plants absorb nitrogen, an essential macronutrient, from the rhizosphere, and soil nitrogen status is thus an important determinant of plant growth and productivity. Plants have evolved numerous mechanisms to induce modulations of nitrogen metabolism and a wide range of physiological processes in response to changes in nitrogen source supply and variation in the internal abundance of nitrogen-containing compounds.

关键词： Nitrogen Signaling Networks Computational Approaches Big Data era

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New era of drug innovation in China

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Acta Pharmaceutica Sinica B 2019年第5期9卷 1084-1085页

作者： Xuan Ye Qingli Wang Haixue Wang Office of Pharmacology and Toxicology Center for Drug Evaluation National Medical Products Administration

In 2018, the China National Medical Products Administration(NMPA) approved new drug applications (NDAs) of 48 new drugs, which was the highest annual approval rate by the Chinese regulatory agency in the past 20 years. Nine of the 48 new drugs,including fruquintinib, anlotinib, toripalimab and sintilimab, are global new molecular entities (NME) that were developed by Chinese pharmaceutical companies.

关键词： New era drug innovation China

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The Solution to Current Psychosocial Problems and the “Unfulfilled Enlightenment” of Modernity in the New era

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学术界 2019年第9期 208-216页

作者： Sun Shujing College of Marxism Henan University of Science and Technology

The transition period of Chinese society has spawned many psychosocial problems in China,which are characterized by high incidence,universality and growth. Compared with social and economic development,the devel-opment of social psychology has been relatively slow for a long time,which has led to the prevalence of psychosocial problems and the lack of modernity cultivation in China's modernization. Xi Jinping theory on socialism with Chi-nese characteristics(SCC) in the new era is a scientific plan for the all - round development and modernization of SCC,and it contains rich ideas of modernity. It is also the ideological inheritance and innovation of Marx's "full and free development of human beings",and the basic strategy of cultivating the modernity of the new era. Therefore,it is an important way to solve the current psychosocial problems in China through the Marxist theory and the "unfulfilled enlightenment" of the theory of the new era.

关键词： psychosocial problems modernity new era unfulfilled enlightenment

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The Logic of Xi Jinping’s Ideas on Social Governance in the New era

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学术界 2020年第2期 185-193页

作者： Ma Dekun School of Marxism Shandong Normal UniversityJinan Shandong 250358

Since the 18th National Congress of the Communist Party of China,General Secretary Xi Jinping,with a long-term vision,has discussed social governance on different occasions in the face of contemporary issues,forming an ideological system with complete structure,rich content,rigorous exposition,and profound *** the perspective of theoretical analysis,these expositions insist on people-centeredness in the value dimension,implement multiple subject participation in the practical dimension,consider promoting the legalization of social governance in the target dimension,draw on the essence of traditional cultural governance in the historical dimension,and focus on diversified governance measures in the method *** important exposition of General Secretary Xi Jinping on social governance is the new development of Chinese Marxist social governance ideas,which will help the steady progress of socialist social governance with Chinese characteristics and the further improvement of socialist governance system with Chinese characteristics.

关键词： socialism with Chinese characteristics the New era social governance logical approach

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The Scientific System of Xi Jinping Thought on Socialist Culture with Chinese Characteristics for a New era

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学术界 2018年第10期 248-260页

作者： Ma Dekun School of Marxism Shandong Normal University Jinan Shandong 250358

Since the 18 th CPC National Congress,the Party Central Committee,with Comrade Xi Jinping as the core,has formed Xi Jinping Thought on Socialism with Chinese Characteristics( Xi's TSCC) for a New era in the process of upholding and developing the great practice of Socialism with Chinese Characteristics( SCC). As an important part of Xi's TSCC for a new era, cultural thought takes the persistence of cultural confidence as its basic foundation,t he promotion of outstanding traditional culture as its important measure,the enhancement of cultural soft power as its strategic goal,t he cultivation &practice of core socialist values as its guide, and the improvement of clean government culture as its fundamental significance,t hus constituting a scientific system with complete structure, rich content and rigorous exposition. This important thought provides a powerful theoretical and practical guide to the work of building a socialist culture with Chinese characteristics in the new era.

关键词： Xi Jinping new era cultural thought scientific system

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Reform and Reconstruction of the Rural Elderly Care Service System in the New era

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学术界 2018年第11期 238-249页

作者： Han Jiangfeng Zhou Enlai School of Government Nankai University

With decades of hard work,socialism with Chinese characteristics has crossed the threshold into a new *** transformation of the principal contradiction in the new era has imposed new and higher requirements on the rural elderly care service ***,the current service system based on welfare-multiplex and urban community environment is often difficult to operate in the rural areas of central and western *** the urban home care service for the aged is inappropriate to the rural reality;community service for the aged faces difficulties in practice;institution care for the aged develops slowly;the synergy among different elderly care service models is *** observing the rural areas of central and western China in the field for a long time,this paper proposes to build the rural elderly care service system based on family supporting,supported by community mutual assistance care,supplemented by institution care for the aged,combined with medical care,and localized with diversified forms for targeted groups according to different *** the system should follow the fundamental guidance of development-oriented family policy,adhere to the governance mode of multiple subjects with one core and respect rural reality,which could provide a feasible way for the reform and reconstruction of the rural elderly care service system.

关键词： new era development-oriented family policy governance mode of multiple subjects with one core the rural elderly care service system

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Key Questions on Reforming China’s Cultural Governance Capability in the Internet era

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2020年第1期14卷 26-47页

作者： LIN Ling China Institute Fudan UniversityShanghai 200433China

In the past ten years,with the rise and popularity of Internet technology,Chinese society has experienced a silent“cultural uprising,”which has formed a part of the lives and habits of contemporary ordinary Chinese at different levels,and has challenged the old pattern of cultural power and *** to identify this phenomenon,and carry out corresponding reforms,as an important aspect of national governance,is an urgent research *** on the observation and analysis of the phenomenon of Chinese Internet culture in recent years,we can explore and summarize several key issues of China’s current cultural governance reform,and try to explain theoretically the influence of cultural prosperity on political power by retrospecting several governance experiences and lessons in *** the era of the new Internet technology,how to truly enhance the nation^basic ability to avoid the situation of dying once and letting *** complexity of contemporary cultural governance comes from the new technological conditions,while the difficult problem runs through the historical understanding of the entire new cultural governance capacity.

关键词： the Internet era “cultural uprising ”cultural governance ideology

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On the Global Significance of XI Jinping＇s Thought on Socialism with Chinese Characteristics for a New era

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华东师范大学学报（哲学社会科学版） 2018年第3期50卷 173-177页

XI Jinping＇s thought on socialism with Chinese characteristics for a new era contains Chinesewisdom for the development of socialism in the world,Chinese experience of realizing modernization in adeveloping country,and Chinese solution to the global governing. It clarifies the theoretical puzzlement of ＂theend of history＂,＂the clash of civilizations＂and ＂Western centrism＂,so that it plays an important role inhuman intellectual history. Therefore,one should adopt an international vision and a global perspective tounderstand and evaluate the theoretical significance and practical value of XI Jinpings thought on socialismwith Chinese characteristics for a new era.

关键词： XI Jinping’s thought on socialism with Chinese characteristics for a new era Chinesewisdom global significance

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