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ENO1 expression and erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment

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Cancer Biology & Medicine 2022年第11期19卷 1598-1616页

作者： Huizhi Sun Jing Mo Runfen Cheng Fan Li Yue Li Yuhong Guo Yanlei Li Yanhui Zhang Xiaoyu Bai Yalei Wang Xueyi Dong Danfang Zhang Jihui Hao Tianjin Medical University Cancer Institute&Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Pathology Tianjin Medical UniversityTianjin300070China

Objective: Hypoxia is an important feature of pancreatic ductal adenocarcinoma(PDAC). Previously, we found that hypoxia promotes ENO1 expression and PDAC invasion. However, the underlying molecular mechanism was remains ***: The relationship between ENO1 expression and clinicopathological characteristics was analyzed in 84 patients with PADC. The effects of CoCl2-induced hypoxia and ENO1 downregulation on the apoptosis, invasion, and proliferation of PDAC cells were evaluated in vitro and in vivo. Hypoxia-and ENO1-induced gene expression was analyzed by transcriptomic ***: The prognosis of PDAC with high ENO1 expression was poor(P erk phosphorylation and inhibiting apoptosis(P erk phosphorylation and inhibits apoptosis, thus leading to PDAC survival and invasion. These results suggest that ENO1 is a potential therapeutic target for PDAC.

关键词： Pancreatic cancer hypoxia ENOl apoptosis erk phosphorylation

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Injury-induced rapid activation of MAPK signaling in dechorionated eggs and larvae of the silkworm Bombyx mori

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Insect Science 2017年第2期24卷 248-258页

作者： Shi-Hong Gu Chien-Hung Chen Department of Biology National Museum of Natural Science Taichung Taiwan China Chung Hwa University of Medical Technol-ogy Tainan County Taiwan China

Previous study showed that diapause in Bombyx mori eggs can be ter- minated by dechorionation and that activation in the mitogen-activated protein kinase （MAPK）/extracellular signal-regulated kinase （erk） in dechorionated cultured eggs is involved in diapause termination. In the present study, the possible mechanism underlying activation of erk upon dechorionation was further investigated. Results showed that me- chanical injury of diapause eggs without medium incubation also resulted in rapid increase in the phospho-erk levels and that injury increased the phospho-erk levels at different stages of both diapause eggs and eggs in which diapause initiation was prevented by HC1. Effects of anaerobiosis on dechorionation-stimulated phospho-erk levels showed that the mechanical injury itself but not the dramatic increase in oxygen uptake upon injury is in- volved in a rapid activation of erk. Chemical anaerobiosis on dechorionation-stimulated phospho-erk levels and the in vivo effect of anaerobiosis showed that the supply of oxygen also plays a role in erk signaling. In addition, injury induced the phosphory- lation of c-jun N-terminal kinases （JNKs） and p38 kinase, components of two parallel MAPK pathways. A kinase assay showed a dramatic increase in .INK kinase activity in egg lysates upon injury. When newly hatched first instar larvae were injured, an increase in the phospho-erk levels similar to that in dechorionated eggs was observed. From the results, we hypothesize that the injury-induced rapid activation of MAPK signaling, which serves as a natural signal for embryonic development, is related to diapause termination in dechorionated eggs.

关键词： Bombyx mori dechorionation embryonic diapause erk phosphorylation injury MAPK

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