When α-alkoxy-β-ketophosphonates,prepared by the Rh(Ⅱ) mediated insertion reaction of α-diazo-β-ketophosphonates into the OH bond of primary alcohols,were reduced either by NaBH4 in the presence of CaCl2 or by DI...
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When α-alkoxy-β-ketophosphonates,prepared by the Rh(Ⅱ) mediated insertion reaction of α-diazo-β-ketophosphonates into the OH bond of primary alcohols,were reduced either by NaBH4 in the presence of CaCl2 or by DIBAL,they respectively gave the corresponding anti or syn stereomeric hydroxyphosphonates with pronounced to complete *** to the action of potassium tert-butoxyde,syn isomers led to the corresponding pure(E) enol ethers in moderate to good *** the same conditions anti isomers led to a mixture of(Z) and(E) enol ethers in rather poor *** sequence was applied to the preparation of some allyl-vinyl ethers with a(E) configuration for the vinylic double bond.
Objective: Hypoxia is an important feature of pancreatic ductal adenocarcinoma(PDAC). Previously, we found that hypoxia promotes ENO1 expression and PDAC invasion. However, the underlying molecular mechanism was remai...
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Objective: Hypoxia is an important feature of pancreatic ductal adenocarcinoma(PDAC). Previously, we found that hypoxia promotes ENO1 expression and PDAC invasion. However, the underlying molecular mechanism was remains ***: The relationship between ENO1 expression and clinicopathological characteristics was analyzed in 84 patients with PADC. The effects of CoCl2-induced hypoxia and ENO1 downregulation on the apoptosis, invasion, and proliferation of PDAC cells were evaluated in vitro and in vivo. Hypoxia-and ENO1-induced gene expression was analyzed by transcriptomic ***: The prognosis of PDAC with high ENO1 expression was poor(P < 0.05). High ENO1 expression was closely associated with histological differentiation and tumor invasion in 84 PDAC cases(P < 0.05). Hypoxia increased ENO1 expression in PDAC and promoted its migration and invasion. Apoptotic cells and the apoptosis marker caspase-3 in the CoCl_(2)-treated ENO1-sh group were significantly elevated(P < 0.05). Transcriptomic sequencing indicated that CoCl_(2)-induced PDAC cells initiated MAPK signaling. Under hypoxic conditions, PDAC cells upregulated ENO1 expression, thereby accelerating ERK phosphorylation and inhibiting apoptosis(P < 0.05). Consistent results were also observed in a PDAC-bearing mouse hindlimb ischemia ***: Hypoxia-induced ENO1 expression promotes ERK phosphorylation and inhibits apoptosis, thus leading to PDAC survival and invasion. These results suggest that ENO1 is a potential therapeutic target for PDAC.
A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was *** a broad range of difluoromthyl enol ethers were read...
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A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was *** a broad range of difluoromthyl enol ethers were readily accessed in good to excellent yields under mild reaction *** studies revealed that the O-difluoromethylation reaction proceeds mainly via a difluorocarbene pathway.
The semi-hydrogenation of alkynols to enols is a crucial process in the production of pharmaceuticals,agrochemicals,fragrances,and flavors that involves a complex set of parallel and consecutive isomerization and hydr...
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The semi-hydrogenation of alkynols to enols is a crucial process in the production of pharmaceuticals,agrochemicals,fragrances,and flavors that involves a complex set of parallel and consecutive isomerization and hydrogenation reactions and proceeds via several key *** view of the industrial importance of large-scale enol production through alkynol hydrogenation,various noble and non-noble metal(e.g.,Ni and Pd)-based catalysts promoting this transformation have been *** paper reviews the design of highly selective catalysts for the semi-hydrogenation of alkynols,focusing on the role of additives,second metals,catalyst supports,and reaction conditions and combining catalytic reaction kinetics with theoretical calculations to establish the reaction mechanism and the decisive factors for boosting ***,a strategy for designing highly efficient and selective catalysts based on the characteristics of aqueous-phase alkynol hydrogenation is proposed.
The title compound (p-methylphenylbis(4, 4-dimethyl-6-hydroxycyclohexene-1-one-2-yl)methane) has been synthesized by the reaction of 4-methylbenzaldehyde and 5, 5-dimethyl-1, 3-cyclohexanedione in N,N-dimethylformamid...
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The title compound (p-methylphenylbis(4, 4-dimethyl-6-hydroxycyclohexene-1-one-2-yl)methane) has been synthesized by the reaction of 4-methylbenzaldehyde and 5, 5-dimethyl-1, 3-cyclohexanedione in N,N-dimethylformamide. Its structure was determined by single crystal X-ray diffraction. The Crystal is monoclinic, space group P21/a, a=0. 9304 (2)nm, b=1. 1754 (2)nm, c=2. 0134 (4)nm, β=102. 40(2)°, Mr= 382. 50, V=2. 1505 (7)nm3, Dc = 1. 181g/cm3, Z=4, μ(MoKα) = 0. 79cm-1, F(000) = *** structure was solved by direct methods, and refined by full-matris least-Squares method to a final R =0. 042 and Rw = 0. 045. The crystal structure shows that there are two conjugated enol form in the molecule.
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