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现代生物医学进展 2017年第12期17卷 2267-2270页

作者：李利玲汪向红刘妮英徐铮铮王少帅湖北省中西医结合医院妇产科湖北武汉430015 华中科技大学同济医学院附属同济医院妇产科湖北武汉430030

目的:探究抑那通对子宫内膜异位症患者术后HE4、ena78水平的影响及临床疗效。方法:选择我院收治的子宫内膜异位症患者64例,将其随机分成实验组及对照组。对照组31例予腹腔镜手术剥除异位囊肿,术后服用孕三烯酮胶囊治疗;实验组33例予腹... 详细信息

目的:探究抑那通对子宫内膜异位症患者术后HE4、ena78水平的影响及临床疗效。方法:选择我院收治的子宫内膜异位症患者64例,将其随机分成实验组及对照组。对照组31例予腹腔镜手术剥除异位囊肿,术后服用孕三烯酮胶囊治疗;实验组33例予腹腔镜手术剥除异位囊肿,术后辅以抑那通治疗。比较两组的临床疗效及治疗前后HE4、ena78水平的变化。结果:实验组总有效率93.9%,显著高于对照组67.7%(Pena78)水平均较治疗前显著下降(Pena78水平较低,差异均具有统计学意义(Pena78水平有关。

关键词：子宫内膜异位症术后抑那通 HE4 ena78

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Cell-free derivatives from mesenchymal stem cells are effective in wound therapy

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World Journal of Stem Cells 2012年第5期4卷 35-43页

作者： Pravin J Mishra Prasun J Mishra Debabrata Banerjee Laboratory of Cancer Biology and Genetics National Cancer InstituteNational Institutes of HealthBethesdaMD 20892-4264United States Department of Medicine The Cancer Institute of New JerseyRobert Wood Johnson Medical SchoolUniversity of Medicine and Dentistry of New JerseyNew BrunswickNJ 08903United States Departments of Pharmacology The Cancer Institute of New JerseyRobert Wood Johnson Medical SchoolUniversity of Medicine and Dentistry of New JerseyNew BrunswickNJ 08903United States

AIM:To compare the efficacy of cell-free derivatives from Bone marrow derived human mesenchymal stem cells(hMSCs) in wound ***:hMSCs have been shown to play an important role in wound *** present study sought to compare efficacy of hMSCs and cell-free derivatives of hMSCs,which may be clinically more relevant as they are easier to prepare,formulate and *** were isolated from human bone marrow and *** lineage differentiation of hMSCs was performed to confirm their *** ability of hMSCs to migrate was evaluated using in vitro and in vivo migration *** lysates and conditioned medium concentrate was prepared from hMSCs(see Methods for details).Wounds were induced in mice and wound areas were measure before and after cell and cell-free derivative *** and proteins were extracted from the skin and cytokine levels were ***:Co-culture of hMSCs with keratinocytes resulted in increased expression of CXCL-12(SDF1) and ena78(CXCL-5) in the conditioned media indicating that the hMSCs can respond to signals from *** wound closure was observed when hMSCs were injected near the site of excisional wounds in athymic as well as NOD/SCID ***,cell-free lysates prepared from hMSCs were also effective in inducing accelerated wound closure and increased expression of SDF1 and CXCL-5 at the wound ***,concentrated media from hMSCs as well as an emulsion containing lysates prepared from hMSCs was also found to be more effective in rapid re-epithelialization than fibroblasts or vehicle-alone *** of cell-free derivatives may help replace expensive wound care approaches including use of growth factors,epidermal/dermal substitutes,synthetic membranes,cytokines,and matrix components,and most importantly avoid transmission of pathogens from human and animal ***:These results encourage development of derivatives of hMSCs for wound care and re-epit

关键词： Stem cell derivatives Keratinocyte Mesenchymal stem cell Cytokine secretion Wound healing,SDF1 ena78 Animal models

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