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effects of reserpine on the development of neuropsychogenic hypertension in dogs

Science China Mathematics 1980年第6期28卷 796-802页

作者：曾贵云谢声杨龙胜权金荫昌 Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Science Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Science Department of Pharmacology Institute of Basic Sciences Chinese Academy of Medical ScienceBeijing

The effects of reserpine on the blood pressure, heart rate, higher nervous activity andplasma catecholamine level during the development of neuropsychogenic hypertension inducedby overstrain of the central nervous system have been studied in dogs. Overstrain (intensified tension) of the higher nervous activities was induced by a scheduleof irregularly arranged strengthening of the conditional stimuli with electric stimuli on theskin. After completion of three stimulative periods, 4 of the 5 untreated control and 2 ofthe 5 reserpine-treated dogs were found to have developed hypertension. The blood pressuremeasured in Chamber A (the room for blood pressure measurement) was much lower than thatmeasured in Chamber B, i.e. in the experimental environment. The results showed that reser-pine may have some inhibitory influence on the development of this model of neuropsycho-genic hypertension, yet it could not prevent its development completely.

关键词： effects of reserpine on the development of neuropsychogenic hypertension in dogs

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