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Cohort Study on Benefit of Martial Supplementation with edta sodium iron in Management of Gravidic Anemia at the University Clinics of Kinshasa

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Open Journal of Obstetrics and Gynecology 2023年第10期13卷 1738-1746页

作者： Andy Muela Mbangama Ndombasi Nelda Lemba Ambis Joëlle Lumaya Nkongolo Freddy Muamba Banza Jésual Lotoy Mubalamata Eugène-Patrick Lukusa Nkashama Bienvenu Kazadi Otem Christian Ndesanzim Feruzi Michel Mangala Department of Gynecology and Obstetrics University Clinics of Kinshasa Kinshasa Democratic Republic of the Congo

Background: Anemia is mainly attributed to nutritional deficiency, especially iron deficiency, which predominates during pregnancy, and is associated with parasitic diseases such as malaria and intestinal parasitosis, acute or chronic diseases such as sickle cell disease, tuberculosis, HIV infection and various micronutrients disorders. It is associated with an increased risk of low birth weight and prematurity and can contribute to impaired cognitive development in early childhood, as well as to maternal mortality. The impact on the fetus is even greater if maternal anemia onset is at an early stage, or prior to pregnancy. iron salts, such as sulfate or fumarate, are widely used in the treatment of gravidic anemia, but due to various gastrointestinal side effects, many pregnant women are not compliant with treatment. sodium iron edta, on the other hand, is highly absorbable and bioavailable. The latter improves hematological values and appears to be free from the usual iron-related side effects, hence compliance with this supplementation. Objectives: To evaluate the evolution of hemoglobin levels after sodium iron edta supplementation at the university Clinics of Kinshasa, to determine the frequency of gravidic anemia, the dose-dependent benefit of sodium iron edta supplementation in pregnant women and to identify factors associated with insufficient hemoglobin gain after supplementation. Methods: This longitudinal cohort will take place in the gynecology department of the University Clinics of Kinshasa from September 2022 to August 2023 and will include at least 54 pregnant women with anemia. Conclusion: The study will enable us to better assess the benefits of sodium iron edta in improving hematological values, as well as its tolerability in pregnant women suffering from anemia during pregnancy in our environment.

关键词： Anemia Pregnancy edta sodium iron Martial Supplementation

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