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TM6SF2 e167k variant Overexpression Promotes expression of Inflammatory Cytokines in the HCC Cell Line HePA 1-6

Journal of Clinical and Translational Hepatology 2019年第1期7卷 27-31页

作者： Shuixian Du Songling Liao Shousheng Liu Yongning Xin Department of Infectious Disease Qingdao Municipal HospitalQingdaoChina Department of Gastroenterology Dalian Medical UniversityDalianChina Central Laboratories Qingdao Municipal HospitalQingdaoChina Department of Gastroenterology Qingdao Municipal HospitalQingdaoChina Digestive Disease key Laboratory of Qingdao QingdaoChina

Background and Aims:Accumulated evidence has shown that chronic liver inflammation is one of the main risks of hepatocellular carcinoma(HCC),and e167k variant of the transmembrane 6 superfamily member 2(TM6SF2)plays an important role in the progression of chronic liver diseases and *** aim of this study was to explore effects of the TM6SF2 e167k variant on expression of the inflammatory cytokines TNF-cα,IL-2,IL-6 and IL-8 in the HCC cell line HePA ***:HePA 1-6 cells were infected with lentivirus containing either the TM6SF2 e167k variant or TM6SF2 wildtype,or control *** real-time polymerase chain reaction(qRT-PCR)and western blotting were conducted to analyze the expression of the inflammatory cytokines TNF-α,IL-2,IL-6 and IL-8.A t-test was used for statistical ***:Compared with the control group and TM6SF2 overexpression group,the relative expression of IL-2 and IL-6 mRNAs were significantly elevated in the TM6SF2 e167k overexpression group(pe relative mRNA expression of IL-8 in theTM6SF2 and TM6SF2 e167k overexpression groups were increased compared to the control group(perences were observed for the expression of TNF-αin each *** expression of TNF-α,IL-2,IL-6 and IL-8 that was tested by western blotting showed the same trends as the qRT-PCR ***:In conclusion,the e167k variant of theTM6SF2 gene could promote the expression of inflammatory cytokines IL-2 and IL-6 in HePA 1-6 cells,suggesting that the TM6SF2 e167k variant may accelerate the progression of HCC.

关键词： Hepatocellular carcinoma TM6SF2 e167k variant Inflammatory

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TM6SF2 e167k variant, a Novel Genetic Susceptibility variant, Contributing to Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2015年第4期3卷 265-270页

作者： Li-Zhen Chen Harry Hua-Xiang Xia Yong-Ning Xin Zhong-Hua Lin Shi-Ying Xuan Department of Gastroenterology Qingdao Municipal HospitalSchool of MedicineQingdao UniversityQingdaoShandongChina Qingdao Municipal Hospital School of MedicineQingdao UniversityQingdaoShandongChina

Nonalcoholic fatty liver disease(NAFLD)is one of the most common causes of liver dysfunction worldwide,and its prevalence is highly associated with genetic *** transmembrane 6 superfamily member 2(TM6SF2)e167k variant represents a general genetic determinant of hepatic triglyceride content and lobular inflammation,and its presence appears to be directly involved in the pathogenesis and development of *** this variant appears to be a novel powerful modifier in the development of NAFLD,whether it is associated with an increased risk of NAFLD-refated liver fibrosis and hepatocellular carcinoma(HCC)remains to be *** aim of this review is to describe the functions of the TM6SF2 e167k variant and its association with NAFLD,with particular emphasis on the underlying mechanisms of its role in the development and progression of ***,the links between the TM6SF2 e167k variant and NAFLD-related liver fibrosis and HCC will be discussed.

关键词： Nonalcoholic fatty liver disease TM6SF2 e167k variant Polymorphism

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