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Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury

Bioactive Materials 2024年第9期39卷 521-543页

作者： Dezun Ma Changlong Fu Fenglu Li Renjie Ruan Yanming Lin Xihai Li Min Li Jin Zhang Academy of Integrative Medicine Fujian University of Traditional Chinese Medicine1 Qiuyang RoadFuzhouFujian350122PR China Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhouFujian350122PR China College of Chemical Engineering Fuzhou University2 Xueyuan RoadFuzhou350108PR China Qingyuan Innovation Laboratory 1 Xueyuan RoadQuanzhou362801PR China Fujian Children’s Hospital Fujian Branch of Shanghai Children’s Medical Center966 Hengyu RoadFuzhou350014PR China Fujian Maternity and Child Health Hospital 111 Daoshan RoadFuzhou350005PR China College of Clinical Medicine for Obstetrics&Gynecology and Pediatrics Fujian Medical University111 Daoshan RoadFuzhou350005PR China

Spinal cord injury(SCI)often results in irreversible loss of sensory and motor functions,and most SCIs are incurable with current medical *** of the hardest challenges in treating SCI is the development of a dysfunctional pathological microenvironment,which mainly comprises excessive inflammation,deposition of inhibitory molecules,neurotrophic factor deprivation,glial scar formation,and imbalance of vascular *** overcome this challenge,implantation of functional biomaterials at the injury site has been regarded as a potential treatment for modulating the dysfunctional microenvironment to support axon regeneration,remyelination at injury site,and functional recovery after *** review summarizes characteristics of dysfunctional pathological microenvironment and recent advances in biomaterials as well as the technologies used to modulate inflammatory microenvironment,regulate inhibitory microenvironment,and reshape revascularization ***,technological limitations,challenges,and future prospects of functional biomaterials to promote efficient repair of SCI are also *** review will aid further understanding and development of functional biomaterials to regulate pathological SCI microenvironment.

关键词： Spinal cord injury dysfunctional pathological microenvironment Functional biomaterials Axon regeneration Functional recovery

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