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Repair mechanism of astrocytes and non-astrocytes in spinal cord injury

World Journal of Clinical Cases 2020年第5期8卷 854-863页

作者： Xiang-Yun Liu Jian-Wei Guo Jian-Qiang Kou Yuan-Liang Sun Xiu-Jun Zheng Department of Spinal Surgery The Affiliated Hospital of Qingdao University

BACKGROUND Spinal cord injury(SCI)is a destructive disease that incurs huge personal and social costs,and there is no effective *** the pathogenesis and treatment mechanism of SCI has always been a strong scientific focus,the pathogenesis of SCI is still under *** To determine the key genes based on the modularization of in-depth analysis,in order to identify the repair mechanism of astrocytes and non-astrocytes in *** Firstly,the differences between injured and non-injured spinal cord of astrocyte(HA),injured and non-injured spinal cord of non-astrocyte(FLOW),injured spinal cord of non-injured astrocyte(HA)and non-injured spinal cord of nonastrocyte(FLOW),and non-injured spinal cord of astrocyte(HA)and nonastrocyte(FLOW)were *** total number of differentially expressed genes was obtained by merging the four groups of differential ***,the genes were co-expressed and ***,the enrichment of GO function and KEGG pathway of module genes was ***,non-coding RNA,transcription factors and drugs that regulate module genes were predicted using hypergeometric *** In summary,we obtained 19 expression modules involving 5216 differentially expressed *** them,miR-494,XIST and other genes were differentially expressed in SCI patients,and played an active regulatory role in dysfunction module,and these genes were recognized as the driving genes of *** results showed that module genes were significantly involved in the biological processes of inflammation,oxidation and *** pathways such as NF-kappa B/A20,AMPK and MAPK were significantly *** addition,non-coding RNA pivot(including miR-136-5p and let-7d-5p,etc.)and transcription factor pivot(including NFKB1,MYC,etc.)were identified as significant regulatory dysfunction *** Overall,this study uncovered a co-expression network of key genes involved in astrocyte and non-astrocyte regulation in

关键词： Astrocyte Non-astrocyte Spinal cord injury Repair mechanism dysfunction module module genes

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