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Analysis of the relationship between bile duct and duodenal microbiota reveals that potential dysbacteriosis is the main cause of primary common bile duct stones

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Synthetic and Systems Biotechnology 2021年第4期6卷 414-428页

作者： Zhitang Lyu Tingting Yu Lichao Zhang Xiaona Xu Yijun Zhang Jihong Li Zhirong Li Wei Zhang Senlin Hou School of Life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaodingPR China The Second Hospital of Hebei Medical University ShijiazhuangPR China Key Laboratory of Microbial Diversity Research and Application of Hebei Province BaodingPR China Engineering Laboratory of Microbial Breeding and Preservation of Hebei Province BaodingPR China

Bacteria play an important role in the formation of primary Common Bile Duct(CBD)stones.However,the composition and function of the microbiota of bile duct in patients with primary CBD stones remained to be explored.We utilized the 16S rRNA gene high-throughput sequencing technology to analyze the microbial diversity and community composition of biliary and duodenal microbiota in 15 patients with primary CBD stones and 4 patients without biliary tract diseases.Alpha diversity analysis showed that the microbiota richness was similar in bile and intestinal fluid;Beta diversity analysis showed that there were differences in the composition between biliary microbiota and the duodenal microbiota,but the abundance of the main groups showed similarities.The composition of the biliary microbiota from gallstone patients was more complex,as was the duodenal microbiota.Proteobacteria and Firmicutes were the dominant bacteria at phylum level,accounting for at least 75%of the total reads in each subgroup.Pseudomonas and Escherichia􀀀Shigella were the major genus among subgroups,but Escherichia-Shigella had increased abundance in duodenal microbiota with primary choledocholithiasis,which may play an important role in stone formation.It is noteworthy that Clostridiumsensu_stricto,Lachnospiraceae_UCG-008,Butyrivibrio and Roseburia which could produce short chain fatty acids(SCFAs),were significantly decreased in biliary microbiota with primary CBD stones(pdysbacteriosis.The decrease in abundance of certain major acid-producing bacteria affects the health of the biliary tract and thus leads to the formation of stones.

关键词： Primary common bile duct stones ERCP dysbacteriosis Bile duct microbiota Duodenal microbiota 16S rRNA gene high-throughput sequencing Short chain fatty acids

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Alterations in gut microbiota are related to metabolite profiles in spinal cord injury

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Neural Regeneration Research 2023年第5期18卷 1076-1083页

作者： Jian-Ning Kang Zheng-Fang Sun Xin-Yu Li Xiao-Di Zhang Zheng-Xin Jin Ce Zhang Ying Zhang Hui-Yun Wang Na-Na Huang Jian-Hao Jiang Bin Ning Central Hospital Affiliated to Shandong First Medical University Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong ProvinceChina Department of Spinal Surgery Jinan Central HospitalCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina School of Clinical Medicine Weifang Medical UniversityWeifangShandong ProvinceChina Department of Traumatic Orthopedics Binzhou Medical University HospitalBinzhou Medical UniversityBinzhouShandong ProvinceChina

Studies have shown that gut microbiota metabolites can enter the central nervous system via the blood-spinal cord barrier and cause neuroinflammation, thus constituting secondary injury after spinal cord injury. To investigate the correlation between gut microbiota and metabolites and the possible mechanism underlying the effects of gut microbiota on secondary injury after spinal cord injury, in this study, we established mouse models of T8–T10 traumatic spinal cord injury. We used 16 S rRNA gene amplicon sequencing and metabolomics to reveal the changes in gut microbiota and metabolites in fecal samples from the mouse model. Results showed a severe gut microbiota disturbance after spinal cord injury, which included marked increases in pro-inflammatory bacteria, such as Shigella, Bacteroides, Rikenella, Staphylococcus, and Mucispirillum and decreases in anti-inflammatory bacteria, such as Lactobacillus, Allobaculum, and Sutterella. Meanwhile, we identified 27 metabolites that decreased and 320 metabolites that increased in the injured spinal cord. Combined with pathway enrichment analysis, five markedly differential amino acids(L-leucine, L-methionine, L-phenylalanine, L-isoleucine and L-valine) were screened out, which play a pivotal role in activating oxidative stress and inflammatory responses following spinal cord injury. Integrated correlation analysis indicated that the alteration of gut microbiota was related to the differences in amino acids, which suggests that disturbances in gut microbiota might participate in the secondary injury through the accumulation of partial metabolites that activate oxidative stress and inflammatory responses. Findings from this study provide a new theoretical basis for improving the secondary injury after spinal cord injury through fecal microbial transplantation.

关键词： 16S rRNA gene amplicon sequencing amino acid metabolism dysbacteriosis gut microbiota inflammation metabolic disturbance metabolites metabolomics secondary injury spinal cord injury

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REGULATION OF INTESTINAL dysbacteriosis OF BURNED RATS BY MICROECOSYSTEM REGULATORS

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Academic Journal of Xi'an Jiaotong University 2001年第1期13卷 39-41页

作者：梅龙楚雍烈熊德鑫祝晓凤 Department of Microbiology Med. Sch. of Xi'an Jiaotong Univ. Xi'an 710061 China

Objective To investigate the feasibility of using synbiotics and probiotics to prevent and cure in- testinal dysbacteriosis after burn. Methods Burned rats were fed with synbiotics and probiotics reagents. and the amounts of major intestinal florae in caecal contents were detected. Results The major physiological anaerobes were mostly stable, and the conditioned pathogens had no abnormal. Conclusion Tke micro-ecosystem regulator can quickly supplement the decreased physiological anaerobes caused by burning,and avoid the occurrence of dysbacterio- sis.

关键词： micro-ecosystem regulator synbiotics probiotics burning dysbacteriosis

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Characteristics of fecal microbial communities in patients with non-anastomotic biliary strictures after liver transplantation

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World Journal of Gastroenterology 2017年第46期23卷 8217-8226页

作者： Jing Zhang Feng-gang Ren Peng Liu Hong-ke Zhang Hao-yang Zhu Zhe Feng Xu-Feng Zhang Bo Wang Xue-ming Liu Xiao-gang Zhang Rong-qian Wu Yi Lv Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong University Institute of Advanced Surgical Technology and Engineering First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi’an Jiaotong University

AIM To explore the possible relationship between fecal microbial communities and non-anastomotic stricture(NAS) after liver transplantation(LT).METHODS A total of 30 subjects including 10 patients with NAS, 10 patients with no complications after LT, and 10 nonLT healthy individuals were enrolled. Fecal microbial communities were assessed by the 16 S r RNA gene sequencing technology.RESULTS Different from the uncomplicated and healthy groups, unbalanced fecal bacterium ratio existed in patients with NAS after LT. The results showed that NAS patients were associated with a decrease of Firmicutes and Bacteroidetes and an increase of Proteobacteria at the phylum level, with the proportion-ratio imbalance between potential pathogenic families including Enterococcaceae, Streptococcaceae, Enterobacteriaceae, Pseudomonadaceae and dominant families including Bacteroidaceae. CONCLUSION The compositional shifts of the increase of potential pathogenic bacteria as well as the decrease of dominant bacteria might contribute to the incidence of NAS.

关键词： Non-anastomotic stricture Orthotopic liver transplantation Fecal microbiota dysbacteriosis Ischemia-reperfusion injury

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Radiation-induced Oral Mucositis is a Critical Dilemma for Patients and Physicians During Radiotherapy for Nasopharyngeal Carcinoma

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Clinical Cancer Bulletin 2022年第2期1卷 95-99页

作者： Zhifeng WU Bingliang WANG Xu ZHOU Bei XU Zhaochong ZENG Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghaiChina200032 Department of Head Neck Surgery Zhongshan HospitalFudan UniversityShanghaiChina200032 Department of Oncology Zhongshan HospitalFudan UniversityShanghaiChina200032

The combination of radiotherapy(RT)and chemotherapy is associated with a high cure rate but an increased risk of radiation-induced oral mucositis(RIOM)in patients with nasopharyngeal carcinoma(NPC).As a dose-limiting complication,RIOM remains a critical dilemma for patients and physicians,potentially leading to radiation interruptions and compromised tumor control.In this review,we discuss and analyze the pathological mechanisms and factors affecting prevention/treatment of RIOM.RT may induce RIOM via a positive feedback loop,consequently amplifying superoxide production,the immunoinflammatory response,dysbacteriosis,infection,and epithelial basal cell death.Routine interventions for RIOM focus on oral care,oral-pain relief,nutritional support,and infection control;however,recent novel and effective methods have been proposed according to the pathological mechanisms and influencing factors.Some patients with low-recurrence-risk NPCs may be treated with reduced-dose RT,reduced-dose chemotherapy,or RT alone(without chemotherapy)to prevent severe RIOM.Furthermore,traditional herbal medicine extracts,such as Kangfuxin and honey,may help to control RIOM.In addition to the routine application of antibiotics to treat oral dysbacteriosis and hormones to suppress immune inflammatory responses,edaravone and GC4419 can also be used to scavenge oxygen free radicals and reduce superoxide ions to protect the oral mucosa and limit the occurrence of RIOM.

关键词： Radiation-induced oral mucositis Nasopharyngeal carcinoma Immunoinflammation dysbacteriosis Avasopasem

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Perioperative changes in lower gut microbiocenosis in patients with colon and rectum cancer

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新疆医科大学学报 2017年第2期40卷 250-255,258页

作者： AleksandrZakharenko PalvanHalmurat AleksandrSuvorov IrinaShlyk OlegTen MihailBelyaev AntonTrushin SergeyBagnenko AdiliAbudurousuli DenisDubrovin i.p.pavlov first st.petersburg state medical university Saint-Petersburg 197022 the first affiliated hospital xinjiang medical universityUrumqi 830054Chin institute of experimental medicine russian academy of scienceSaint-Petersburg 197376Russia xinjiang medical university Urumqi 830011China

This clinical study was designed to determinate the value of colon microbiota microflora in colorectal cancer patients.We investigate pre-and post-operation stool samples in patients with different tumor localizations,trying to correlate those to postoperative complications.Our findings shows that if opportunistic pathogenic microflora levels are elevated before operations,it can lead to further microbiota disbalance in postoperative period,especially in cases of antibacterial prophylaxis or treatment.Further,this changes increase a chance of receiving some complications after surgery.So,we suggest an analysis of stool microbiota in patients with colorectal cancer to be performed prior and after the operation.Furthermore,aperioperative decontamination therapy should be performed in cases of pathogenic microflora levels elevation.Still,monitoring aperioperative microbiota changes is not a routine in most recommendations and we assume that including this relatively unencumbered patient testing in preoperative survey will help to reduce a number of postoperative complications.

关键词： colorectal cancer colon microbiota microflora dysbacteriosis colitis antibacterial prophylaxis or treatment

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Research on the influence of traditional Chinese medicine therapy on the intestinal flora in obese patients

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TMR Non-Drug Therapy 2019年第1期2卷 2-8页

作者： Pei-Yao Li Wen-Wen Zhao Chun-Hua Zhang Hui-Xin Ding Ling Wang Heng Yang Chun-Guang Yu College of Nursing Beijing University of Traditional Chinese Medicine Beijing China

In recent years, the prevalence of obesity has been increasing year by year, leading to a rise in serious complications. The pathogenesis of obesity is complicated in which the intestinal flora plays an important role. Intestinal micro ecology is composed of large and complex intestinal flora that participate in important physiological functions such as metabolism, energy conversion, maintaining intestinal mucosal defense function, and promoting immune system development and maturation and other important physiological functions;furthermore, they are influenced by the host’s genetic background, diet, and other factors. Therefore, intestinal microflora has potential as a new field of drug therapy. At present, it is found that traditional Chinese medicine therapy may prevent and treat obesity by interfering with the intestinal flora, which is expected to become one of the main treatment methods for obese patients. However, its mechanism of action remains unclear. The balance of intestinal flora can be adjusted by acupuncture, massage, and acupoint application. By analyzing the mechanism of obesity caused by intestinal micro ecology and the impact of obesity on the host’s intestinal micro ecological environment, this paper discusses the influence of oral Chinese medicine, acupuncture, massage, acupoint sticking, and other traditional Chinese medicine therapies on the intestinal microflora in obese patients and provides a scientific basis for its clinical application.

关键词： Intestinal microflora Obesity Traditional Chinese medicine dysbacteriosis

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