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Hepatoprotective activity of dypsis lutescens against D-galactosamine-induced hepatotoxicity in rats and its phytoconstituents

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Asian Pacific Journal of Tropical Biomedicine 2019年第11期9卷 467-473页

作者： Mai M.El-Ghonemy Walaa A.El-Kashak Tahia K.Mohamed Enayat A.Omara Jihan Hussein Abdel-Razik H.Farrag Mahmoud I.Nassar Mohamed Y.El-Kady Chemistry of Natural Compounds Department National Research Centre33 El-Bohouth St.Dokki12622CairoEgypt Department of Pathology National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Medical Biochemistry Department National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Chemistry Department Faculty of ScienceAin Shams UniversityCairoEgypt

Objective:To isolate and identify the polyphenolic constituents of dypsis lutescens,and evaluate the hepatoprotective activity of the ethanolic extract of dypsis lutescens ***:Hepatoprotective,antioxidant and anti-inflammatory effects of two doses of dypsis lutescens ethanolic leaf extract were investigated in five groups of six rats each administered with the ethanolic extract of dypsis lutescens *** function parameters were assessed,histopathological study was carried out,the anti-inflammatory mediators and the antioxidant potential in the liver tissues were *** addition,the total ethanolic extract of dypsis lutescens leaves was subjected to different chromatographic separation techniques to yield ten phenolic *** isolated compounds structures were spectroscopically ***:Hepatoprotective activity of dypsis lutescens ethanolic extract was estimated for the first time and showed significant activity against histopathological changes induced by D-galactosamine in *** extract improved the liver *** to the D-galactosamine group,the architecture of the liver in the treated groups was improved in the histopathological *** results proved the hepatoprotective activity of dypsis lutescens and its ability in attenuating liver oxidative damage and *** investigations of the total extract afforded ten compounds from the genus ***:The alcoholic extract of dypsis lutescens exerted potential hepatoprotective action,maintaining liver health and functions.

关键词： dypsis lutescens Flavonoid glycosides Phenolic acids Hepatoprotective Antioxidant Anti-inflammatory

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