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Bioactive superparamagnetic iron oxide-gold nanoparticles regulated by a dynamic magnetic field induce neuronal Ca^(2+)influx and differentiation

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Bioactive Materials 2023年第8期26卷 478-489页

作者： Elias Georgas Muzhaozi Yuan Jingfan Chen Ya Wang Yi-Xian Qin Department of Biomedical Engineering The State University of New York at Stony BrookStony BrookNYUnited States J.Mike Walker’66 Department of Mechanical Engineering Texas A&M UniversityCollege StationTXUnited States Department of Biomedical Engineering Texas A&M UniversityCollege StationTXUnited States Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTXUnited States

Treating neurodegenerative diseases,e.g.,Alzheimer’s Disease,remains a significant challenge due to the limited neuroregeneration rate in the brain.The objective of this study is to evaluate the hypothesis that external magnetic field(MF)stimulation of nerve growth factor functionalized superparamagnetic iron oxide-gold(NGF-SPIO-Au)nanoparticles(NPs)can induce Ca^(2+)influx,membrane depolarization,and enhance neuron differentiation with dynamic MF(DMF)outperforming static MF(SMF)regulation.We showed the that total intracellular Ca^(2+)influx of PC-12 cells was improved by 300%and 535%by the stimulation of DMF(1 Hz,0.5 T,30min)with NGF-SPIO-Au NPs compared to DMF alone and SMF with NGF-SPIO-Au NPs,respectively,which was attributed to successive membrane depolarization.Cellular uptake performed with the application of sodium azide proved that DMF enhanced cellular uptake of NGF-SPIO-Au NPs via endocytosis.In addition,DMF upregulated both the neural differentiation marker(β3-tubulin)and the cell adhesive molecule(integrin-β1)with the existence of NGF-SPIO-Au NPs,while SMF did not show these effects.The results imply that noninvasive DMF-stimulated NPs can regulate intracellular Ca^(2+)influx and enhance neuron differentiation and neuroregeneration rate.

关键词： Calcium influx Membrane potential dynamic magnetic fields Neuroregeneration SPIO-Au Core-shell nanoparticles

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