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dynamic degradation patterns of porous polycaprolactone/β-tricalcium phosphate composites orchestrate macrophage responses and immunoregulatory bone regeneration

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Bioactive Materials 2023年第3期21卷 595-611页

作者： Hao Wu Xinghui Wei Yichao Liu Hui Dong Zhen Tang Ning Wang Shusen Bao Zhigang Wu Lei Shi Xiongfei Zheng Xiaokang Li Zheng Guo Department of Orthopaedics Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038PR China Department of Orthopaedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi710032PR China Department of Orthopaedics The 63750 Hospital of People’s Liberation ArmyXi’anShaanxi710038PR China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyangLiaoning110000PR China

Biodegradable polycaprolactone/β-tricalcium phosphate(PT)composites are desirable candidates for bone tissue engineering applications.A higherβ-tricalcium phosphate(TCP)ceramic content improves the mechanical,hydrophilic and osteogenic properties of PT scaffolds in vitro.Using a dynamic degradation reactor,we estab-lished a steady in vitro degradation model to investigate the changes in the physio-chemical and biological properties of PT scaffolds during degradation.PT46 and PT37 scaffolds underwent degradation more rapidly than PT scaffolds with lower TCP contents.In vivo studies revealed the rapid degradation of PT(PT46 and PT37)scaffolds disturbed macrophage responses and lead to bone healing failure.Macrophage co-culture assays and a subcutaneous implantation model indicated that the scaffold degradation process dynamically affected macro-phage responses,especially polarization.RNA-Seq analysis indicated phagocytosis of the degradation products of PT37 scaffolds induces oxidative stress and inflammatory M1 polarization in macrophages.Overall,this study reveals that the dynamic patterns of biodegradation of degradable bone scaffolds highly orchestrate immune responses and thus determine the success of bone regeneration.Therefore,through evaluation of the biological effects of biomaterials during the entire process of degradation on immune responses and bone regeneration are necessary in order to develop more promising biomaterials for bone regeneration.

关键词： Polycaprolactone/β-TCP dynamic degradation Macrophage response Bone healing

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A novel algorithm to analyze the dynamics of digital chaotic maps in finite-precision domain

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Chinese Physics B 2023年第1期32卷 207-216页

作者：范春雷丁群 Electrical Engineering College Heilongjiang UniversityHarbin 150080China

Chaotic maps are widely used to design pseudo-random sequence generators, chaotic ciphers, and secure communication systems. Nevertheless, the dynamic characteristics of digital chaos in finite-precision domain must be degraded in varying degrees due to the limited calculation accuracy of hardware equipment. To assess the dynamic properties of digital chaos, we design a periodic cycle location algorithm(PCLA) from a new perspective to analyze the dynamic degradation of digital chaos. The PCLA can divide the state-mapping graph of digital chaos into several connected subgraphs for the purpose of locating all fixed points and periodic limit cycles contained in a digital chaotic map. To test the versatility and availability of our proposed algorithm, the periodic distribution and security of 1-D logistic maps and 2-D Baker maps are analyzed in detail. Moreover, this algorithm is helpful to the design of anti-degradation algorithms for digital chaotic dynamics. These related studies can promote the application of chaos in engineering practice.

关键词： digital chaos dynamic degradation state-mapping graph periodicity analysis

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Fluid-induced corrosion behavior of degradable zinc for stent application

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Journal of Materials Science & Technology 2021年第32期91卷 134-147页

作者： Kai Chen Xuenan Gu Hui Sun Hongyan Tang Hongtao Yang Xianghui Gong Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Materials Science and Engineering The Ohio State UniversityColumbusOH43210USA

The influence of laminar flow on the corrosion of pure zinc(Zn) and cell response was investigated and compared with the static measurements.The results revealed that laminar flow accelerated the corrosion and enhanced the localized corrosion of pure Zn.The dynamic corrosion rate was 0.184 mm/yr after 168 h corrosion.More corrosion products were formed under flow condition,which were mainly composed of Zn_(3)(PO_(4))_(2)·4 H_(2) O,Ca_(3)(PO_(4))_(2),ZnO and Zn_(5)(OH)_(6)(CO_(3))_(2).Moreover,the adhered rat aortic endothelial cells(RAEC) on Zn samples exhibited notably cell loss and round configuration under laminar flow.

关键词： Zinc Laminar flow dynamic degradation Endothelial cells Biocompatibility

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