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Comparison between high-frequency irreversible electroporation and irreversible electroporation ablation of small swine liver:follow-up of DCE-MRI and pathological observations

引用

Chinese Medical Journal 2021年第17期134卷 2081-2090页

作者： Jing Li Xiao-Bo Zhang Jing-Jing Wang Lu-Jia Jin Hu-Sheng Shan Xiao Zhang Li Ma Xiao-Dong Xue Xin Zhang Zhong-Liang Zhang Liang-Liang Meng Fei Yuan Yue-Yong Xiao Medical School of Chinese People’s Liberation Army Beijing 100853China Department of Radiology Characteristic Medical Center of Chinese People’s Armed Police ForceTianjin 300162China Department of Radiology The First Medical Center of the General Hospital of the People’s Liberation ArmyBeijing 100853China Department of Intensive Care Unit Tianjin First Central HospitalTianjin 300152China Department of General Surgery The First Medical Center of the General Hospital of the People’s Liberation ArmyBeijing 100853China Department of Radiotherapy Huai’an Medical AreaGeneral Hospital of the Eastern Theater CommandHuai’anJiangsu 223001China Department of Anesthesiology The First Medical Center of the General Hospital of the People’s Liberation ArmyBeijing 100853China

Background:High-frequency irreversible electroporation(H-FIRE)is a novel,next-generation nanoknife technology with the advantage of relieving irreversible electroporation(IRE)-induced muscle ***,the difference between IRE and H-FIRE with distinct ablation parameters was not clearly *** study aimed to compare the efficacy of the two treatments in ***:Ten Bamaminiature swinewere divided into two group:five in the 1-day group and five in the 7-day *** efficacy of IRE and H-FIRE ablation was compared by volume transfer constant(Krans),rate constant(Kep)and extravascular extracellular volume fraction(Ve)value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI),size of the ablation zone,and histologic *** animal underwent the IRE *** of the electrodesweremeasured during ***-MRI images were obtained 1,4,and 7 days after ablation in the 7-day *** animals in the two groups were euthanized 1 day or 7 days after ablation,and subsequently,IRE and H-FIRE treated liver tissues were collected for histological ***’s t test or Mann-Whitney U test was applied for comparing any two ***-way analysis of variance(ANOVA)test and Welch’s ANOVA test followed byHolm-Sidak’smultiple comparisons test,one-wayANOVAwith repeatedmeasures followed by Bonferroni test,or Kruskal-Wallis H test followed by Dunn’s multiple comparison test was used for multiple group comparisons and post hoc *** correlation coefficient test was conducted to analyze the relationship between two ***:Higher Ve was seen in IRE zone than in H-FIRE zone(0.14±0.02 vs.0.08±0.05,t=2.408,P=0.043)on day 4,but no significant difference was seen in Ktrans or Kep between IRE and H-FIRE zones at all time points(all P>0.05).For IRE zone,the greatest Ktrans was seen on day 7,which was significantly higher than that on day 1(P=0.033).The ablation zone size of H-FIRE was significantly larger th

关键词： Irreversible electroporation High-frequency irreversible electroporation dynamic contrast enhanced-magnetic resonance imaging Thermal damage

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