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Chinese Chemical Letters 2023年第8期34卷 158-161页

作者： Liping Huang Mingyun Liang Yajun Fang Jehan Kim Yuntian Yang Zhegang Huang PCFM LIFM LabSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Optical Chemicals Xinhuayue GroupMaoming 525000China Shenzhen Grubbs Institute Department of ChemistrySouthern University of Science and TechnologyShenzhen 518055China Pohang Accelerator Laboratory PostechPohangGyeongbukKorea

Due to the high local concentration of substrates in confined space, porous solid Bronsted acids have been extensively explored for efficient acid-catalyzed reaction. However, the porous structures with strong Bronsted acids lack long-term stability due to chemical hydrolysis. Moreover, the products inhibition effect in confined rigid cavities severely obstructs subsequent catalysis. Here, tubular Bronsted acid catalyst with unique recognition of protons was presented by self-assembly of p H-responsive aromatic amphiphiles. The responsive assembly could mechanically transfer hydrogen ions from low-concentration acidic solution into tubular defined pores, thereby producing effective catalytic activity for Mannich reactions in mildly acidic solution. Notably, the tubular catalyst unfolded into flat sheets upon addition of triethylamine for efficient release of products, which could be recovered by subsequent acidification and the catalytic activity still remained. Therefore, the porous Bronsted acid with reversible assembly provides a new strategy for mass synthesis through increasing conversion times.

关键词： Tubular Brosted acid Protonic recognition dynamic assembly Heterogeneous catalysis Large-scale synthesis

内源性双miRNA触发响应的DNA纳米结构动态自组装用于原位递送siRNA

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Science China Materials 2023年第7期66卷 2938-2946页

作者：钟武坤黄蕾林玉红邢超卢春华 MOE Key Laboratory for Analytical Science of Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350116China Institute of Nanobiomaterials and Immunology School of Life ScienceTaizhou UniversityTaizhou 318000China Fujian Key Laboratory of Functional Marine Sensing Materials Center for Advanced Marine Materials and Smart SensorsMinjiang UniversityFuzhou 350108China

通过多重miRNA触发的原位siRNA递送治疗策略可以有效提高对癌细胞的精确治疗.基于DNA纳米结构的可编程性、特异性分子识别、易于功能化修饰和良好生物相容性的特点,我们设计了一个3D DNA纳米治疗平台,用于实现双miRNA触发响应的siRNA原... 详细信息

通过多重miRNA触发的原位siRNA递送治疗策略可以有效提高对癌细胞的精确治疗.基于DNA纳米结构的可编程性、特异性分子识别、易于功能化修饰和良好生物相容性的特点,我们设计了一个3D DNA纳米治疗平台,用于实现双miRNA触发响应的siRNA原位递送.这种3D DNA纳米结构(TY1Y2)是由DNA四面体支架、两组Y型DNA(Y1和Y2)和EpCAM核酸适体通过自组装构建而成的.TY1Y2被特异性内化至靶标癌细胞后,能够被两个内源性miRNA(miR-21和miR-122)触发,从而产生强的荧光共振能量转移信号,用于双miRNAs成像.同时,治疗性的siRNA(siSurvivin和siBcl2)也可以通过链置换反应从TY1Y2中产生并进行原位释放,实现癌细胞的协同基因治疗.这种3D DNA纳米结构将内源性生物标记物的特异性成像和治疗性基因的原位递送整合为一个多功能纳米平台,在癌症诊断和治疗方面显示出广阔的应用前景.

关键词： DNA tetrahedra dynamic assembly miRNA in-situ delivery cell imaging gene therapy

Host–Guest Interaction Driven Peptide assembly into Photoresponsive Two-Dimensional Nanosheets with Switchable Antibacterial Activity

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CCS Chemistry 2021年第7期3卷 1949-1962页

作者： Xiaoming Xie Bo Gao Zhiyuan Ma Junqing Liu Jianfeng Zhang Jing Liang Zhijun Chen Lixin Wu Wen Li State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012 School of Life Sciences Jilin Province Innovation Platform of Straw Comprehensive Utilization TechnologyJilin Agricultural UniversityChangchun 130118

Selectively controlling the bioactivity of antimicrobial peptides is not only a fascinating scientific challenge but also a necessity in localized antibacterial ***,a smart antimicrobial system has been fabricated via host–guest driven dynamic selfassembly between a branched cyclodextrin and cationic linear peptides appended with azobenzene side *** self-assembly structure of the host–guest system could be controlled reversibly through the photoresponsive isomerization of azobenzene moieties.

关键词： peptide azobenzene dynamic assembly photoresponsive antibacterial activity

dynamic Assemblies and Photophysical Changes of Zinc Porphyrin Dimer Regulated by N-Containing Ligands

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Chinese Journal of Chemistry 2007年第11期25卷 1632-1640页

作者：周再春贺林朱义州郑健禺 State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University Tianjin 300071 China

Zinc porphyrin dimer （1） has been designed and synthesized as a novel host of N-containing ligands. The assembly behavior and photophysical changes of its host-guest complexes were evaluated by IH NMR, fluorescence, and UV-visible titrations, and the processes reveal that the host-guest assembly first creates a stable sandwich complex, then an axial coordination equilibrium appears between the sandwich complex and free ligand. The changes of absorption spectra of the assembly processes rely on the stabilities of the complexes, and fluorescence quenching depends on the axial coordination equilibrium, which indicates that the axial ligation/de-ligation dynamics is indeed a pathway from the excited state to the ground state for metalloporphyrin complexes.

关键词： dynamic assembly ligand exchange fluorescence quenching porphyrin dimer

Spatiotemporally controlled emergence of nanoparticle microvortices under electric field

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Aggregate 2024年第2期5卷 290-300页

作者： Qi Pan Xijian Lin Shiyuan Wei Jinghong Su Hansen Zhao Xiaojie Duan Guoqing Hu Yan He Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijingChina Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijingChina Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina The State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijingChina School of Engineering Science University of Chinese Academy of SciencesBeijingChina Department of Engineering Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhouChina

Controlled assembly of nanoparticles(NPs)has garnered much interest over the past two *** established techniques,new methods utilizing local short-range or large-scale long-range interactions remain to be explored to achieve diverse micro-and nanoscale ***,we report the controlled emergence of vortex-pair arrays within monodispersed gold nanorods by applying a direct current electric field across a pair of sawtooth *** employing in situ darkfield microscopy and particle collective analysis,we elucidate the mechanism behind the formation and stabilization of the NP vortices,attributing it to the combined effects of the electrode shape,high NP density,and high solution *** further explore the controllability of the vortex-pair arrays and obtain multiple complex vortice *** findings will facilitate the investigation of efficient and controlled dynamic assembly of NPs under external fields and help manufacture next-generation optoelectronic functional materials.

关键词： dynamic assembly electric field gold nanoparticles sawtooth electrodes vortex

Synthesis of Finite Molecular Nanotubes by Connecting Axially Functionalized Macrocycles

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CCS Chemistry 2022年第12期4卷 3772-3780页

作者： Liang-Liang Mao Hongyan Xiao Jin-Qin Zhao Zhuo Diao Wen Zhou Hongwei Li Chen-Ho Tung Li-Zhu Wu Huan Cong Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 Key Laboratory of Bio-Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049 Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Beijing NMR Center Peking UniversityBeijing 100871

Monodispersed molecular nanotubes,particularly those with uniform lengths,are challenging targets for chemical ***,we report the general design and efficient synthesis of finite molecular nanotubes,utilizing a dynamic assembly strategy to precisely stack axially functionalized macrocycles by chemical *** tubular molecules,ranging from 7.8 to 19.8 kDa with covalent or coordinative connections,have been prepared from modular macrocyclic building blocks through highly convergent *** discrete molecular nature and structural anisotropy of these synthetic tubes warrant postsynthesis modifications and solution processing methods,as demonstrated by the controllable orientations when deposited onto different prefabricated surfaces.

关键词： molecular nanotube dynamic assembly macrocycle covalence coordination