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Improved Performance in Differentiating Benign from Malignant Sinonasal Tumors Using Diffusion-weighted Combined with dynamic contrast-enhanced Magnetic Resonance Imaging

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Chinese Medical Journal 2015年第5期128卷 586-592页

作者： Xin-Yan Wang Fei Yan Hui Hao Jian-Xing Wu Qing-Hua Chen Jun-Fang Xian Department of Radiology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Radiology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Capital Medical University Beijing 100069 China

Background：Differentiating benign from malignant sinonsal lesions is essential for treatment planning as well as determining the patient＇s prognosis,but the differentiation is often difficult in clinical *** study aimed to determine whether the combination of diffusion-weighted （DW） and dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI） can improve the performance in differentiating benign from malignant sinonasal ***：This retrospective study included 197 consecutive patients with sinonasal tumors （116 malignant tumors and 81 benign tumors）.All patients underwent both DW and DCE-MRI in a 3-T magnetic resonance *** different settings ofb values （0,700 and 0,1000 s/mm^2） and two different strategies of region of interest （ROI） including whole slice （WS） and partial slice （PS） were used to calculate apparent diffusion coefficients （ADCs）.A DW parameter with WS ADCsb0.1000 and two DCE-MRI parameters （time intensity curve [TIC] and time to peak enhancement [Tpeak]） were finally combined to use in differentiating the benign from the malignant tumors in this ***：The mean ADCs of malignant sinonasal tumors （WS ADCsb0,1000=1.084 × 10^-3 mm^2/s） were significantly lower than those of benign tumors （WS ADCsb0,1000=1.617 × 10^-3 mm^2/s,P 〈 0.001）.The accuracy using WS ADCsb0,1000 alone was 83.7% in differentiating the benign from the malignant tumors （85.3% sensitivity,81.2% specificity,86.4% positive predictive value [PPV],and 79.5% negative predictive value [NPV]）.The accuracy using DCE with Tpeak and TIC alone was 72.1% （69.1% sensitivity,74.1% specificity,77.5% PPV,and 65.1% NPV）.Using DW-MRI parameter was superior than using DCE parameters in differentiation between benign and malignant sinonasal tumors （P 〈 0.001）.The accuracy was 87.3% （90.5% sensitivity,82.7% specificity,88.2% PPV,and 85.9% NPV） using DW-MRI combined with DCE-MRI,which was superior than that using DCE-MRI alone or using DW-MRI alone （both P 〈 0.001） in d

关键词： Diffusion-weighted dynamic contrast-enhanced Magnetic Resonance Imaging Nasal Cavity Neoplasm, Paranasal Sinus

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Prostatic Cancer: Diagnosis and Differentiation by dynamic contrast-enhanced MRI

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The Chinese-German Journal of Clinical Oncology 2005年第2期4卷 116-120页

作者：史浩丁红宇张广英杨贞振济南市山东医学影像学研究所 250021

To assess the role of dynamic contrast-enhanced MRI (DCE-MRI) in thediagnosis and differentiation of prostatic cancer (PC). Methods: Five volunteers, 36 patients withbenign prostatic hyperplasia (BPH) and 13 patients with biopsy-proven prostate cancer underwentconventional MRI, DCE-MRI and delayed enhancement MRI. The value of the signal intensity in DCE-MRIwas measured and calculated to draw the time-signal intensity curve of the normal peripheral zone(PZ), the prostate cancer and the benign prostatic hyperplasia. Results: In DCE-MRI, the normalperipheral zone was enhanced mildly and slowly and the peak value was located in late phase. Theenhancement of the lesions in 36 patients with the benign prostatic hyperplasia was obvious in earlyphase and strengthened gradually, and then turned to decrease in late phase after peak value. Thelesions in 9 of 13 cases with prostate cancer were enhanced obviously in early phase and washed outrapidly, and the peak value was located in early phase, but the peak value was in mediate and latephase in the other 4 cases with diffuse lesion in the prostate on T_2WI. Conclusion: In DCE-MRI, theenhancement patterns of the normal peripheral zone, the prostate cancer and the benign prostatichyperplasia were significantly different. DCE-MRI was very useful in the diagnosis anddifferentiation of prostate cancer.

关键词： magnetic resonance imaging dynamic contrast-enhanced prostate cancer benign prostate hyperplasia

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Usefulness of dynamic contrast-enhanced MR imaging in the evaluation of pulmonary isolated lesions

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The Chinese-German Journal of Clinical Oncology 2010年第6期9卷 334-336页

作者： Zhiyong Li Tingting Zhang Jianlin Wu Wei Liu Qiang Wei Bin Xu Rui Han Department of Radiology The First Affiliated Hospital of Dalian Medical University Dalian 116011 China

Objective： The aim of our study was to investigate the value of dynamic contrast-enhanced MRI for evaluating differential diagnosis of pulmonary isolated lesions. Methods： Twenty-nine consecutive patients enrolled in this study, all of whom underwent DCE-MRI examinations and received a histologic and clinical diagnosis. Among these, lung tuberculoma 7 cases, harmatoma 3 cases, peripheral lung cancer 19 cases. DCE-MRI was acquired with 3D LAVA technique, total 18 phases were acquired, scanner time of per phase was 5-7″. After contrasting agent, twice successive scanning was acquired at 10″ and 50″. Then 1′30″, 2′, 2′30″, 3′, 3′30″, 4′, 5′, 6′, 7′, 8′, 9′, 10′, 11′, 12′ performed scanning. Region of interest was placed on the Maximum level in the tumors. According to Schaefer＇s standard, four types of time signal intensity curve （TIC） were classified, which were A, B, C and D. Compared the dynamic parameters between benign and malignant nodules. Results： Lung tuberculoma may display three curves： A type 1 case, ring-shaped enhancement 4 cases （periphery ring A type, central region D type）, D type 2 cases. Harmatoma may display three curves： A type 1 case, C type 2 case. Peripheral lung cancer may display A type. Except 2 cases D type lung tuberculoma, we compared curve data of 8 cases benign nodules （including tuberculoma Atype and periphery ring Atype, harmatoma Atype and C type） and lung cancer. SlEP%： benign nodules 0.7885 ±0.5543, lung cancer 1.2623 ±0.3059, P 〈 0.05; MER： benign nodules 1.0007 ± 0.4251, lung cancer 1.3694 ±0.2740, P 〈 0.05; washout： P 〉 0.05. Conclusion： Lung MR imaging is helpful to diagnosis and differential diagnosis of isolated benign and malignant nodules. SIEP% and MER could offer valuable information. The evolution of global tuberculosis may be from A type to ring-shaped ennoblement to D type. It was easy to do right diagnosis to lung tuberculoma with ring-shaped ennoblement and D type. Peripheral lung cancer commonly displayed A type and

关键词： non-small cell lung carcinoma dynamic contrast-enhanced MRI time signal intensity curve diagnosis

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Application Value of Multimodal Magnetic Resonance Imaging in the Diagnosis of Atypical Hepatocellular Carcinoma

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Chinese Journal of Biomedical Engineering(English Edition) 2020年第3期29卷 33-39页

作者： Bo Li Naixin Wang Dazhi Sun Lixin Liu Department of Radiology Tianjin Third Central HospitalTianjin 300170China

Objective This study aims to explore the application value of multimodal magnetic resonance imaging(MRI)in the diagnosis of atypical hepatocellular carcinoma(HCC).Methods 80 patients with atypical HCC who were admitted to our hospital from August 2018 to February 2020 were selected as the research *** patients underwent dynamic computed tomography(CT)enhancement scans,and then multimodal MRI scans,including an MRI plain scan,dynamic contrastenhancement(DCE),and diffusion-weighted imaging(DWI).Then,the image data were *** The diagnostic accuracy of the observation group(95.00%)was significantly higher than that of the control group(75.00%).This difference was statistically significant(χ2=6.128,P<0.05).With the increase of the b value,the apparent diffusion coefficient(ADC)values of the liver tissue and liver cancer tissue gradually *** with normal liver tissue,the ADC value of liver cancer tissue was significantly lower than that of normal liver tissue(P<0.05).A plain MRI scan of 89 lesions,DCE examination of 93 lesions,(1)7 lesions were slow-rising and fast-falling;(2)72 lesions were fast-rising and fast-falling;(3)10 were platform-type lesions;(4)4 lesions had no *** The diagnostic efficiency of a multimodal MRI in the diagnosis of atypical HCC is high,and it has particular clinical application value.

关键词： Multimodal magnetic resonance imaging Hepatocellular carcinoma Atypical manifestations Diffusion-weighted imaging dynamic contrast-enhanced

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Evaluation of MRI in Diagnosing Hilar Cholangiocarcinoma

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The Chinese-German Journal of Clinical Oncology 2005年第4期4卷 199-202页

作者：刘玉林孔祥泉徐海波彭振军于群熊茵湖北省肿瘤医院放射科 430079

Objective： To investigate the clinical application of MRI in the diagnosis and preoperative evaluation of hilar cholangiocarcinoma （HC）. Methods： Thirty-four cases of HC were examined with 1.5T super-conduct MR unit. The plain MRI and MRCP were followed by dynamic Gd-DTPA （0.1 mmol/kg） contrast-enhanced scanning, which was repeated at 30 s intervals in the first 3 min with the patient being remained in the same position. Delayed scanning was done at 5, 8, 10, 12 and 15 min respectively. 3D- DCE-MRA was performed in arterial and portal venous phase with an additional bolus injection of 15-20 mL Gd-DTPA （0.15-0.20 mmol/kg）. The contrast time-signal curve of both the liver and the tumor was drawn from DCE imaging, and both arterial and portal venous phase imaging were reconstructed with MIP. MRI findings were compared with surgical findings and pathology. Results： Hilar lesion, intrahepatic ducts dilatation and disconnect of main hepatic duct were shown in all cases. Thirty-one cases had tumor-delayed enhancement. In 3D-DCE-MRA, spiral artery deformed was displayed in 6 cases, infiltration, encasement or occlusion of portal vein was displayed in 18 cases. The accuracy of assessing tumor unresectability and resectability by preoperative MRI was 95.0% （19/20） and 78.6% （11/14） respectively. The total accuracy rate of MRI assessing was 88.2% （30/34）. Conclusion： All-in-one MR, including plain MR, MRCP, MR DCE and 3D-DCE-MRA, can accurately show the lesions and involvement of neighbouring tissues. It was of great value in diagnosis and preoperative evaluation of HC.

关键词： hilar, cholangiocarcinoma magnetic resonance imaging dynamic contrast-enhanced

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