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Chinese Journal of Plastic and Reconstructive surgery 2024年第3期6卷 142-148页

作者： Malay sarkar Nitin Kashyap Irappa Madabhavi Department of Pulmonary Medicine Indira Gandhi Medical CollegeShimla 171001Himachal PradeshIndia Department of Plastic and Reconstructive surgery Atal Institute of Medical SuperspecialitiesShimla 171001Himachal PradeshIndia Department of Medical and Pediatric Oncology and Hematology Jawaharlal Nehru Medical CollegeKLE Academy of Higher Education and ResearchBelagaviKarnataka 590010India

dupuytren’s disease is a well-known benign fibroproliferative disorder that affects the palmar and digital fasciae of the *** spectrum includes nodule formation,cord formation,and flexion contracture of the digits,which may result in functional *** deformities are often progressive and *** is a cornerstone *** review discusses the epidemiology,pathophysiology,risk factors,clinical manifestations,and management of dupuytren’s disease.

关键词： dupuytren’s contracture dupuytren’s disease Palmar aponeurosis Fasciectomy

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Downregulation of scar Fibroblasts by Antineoplastic Drugs: A Potential Treatment for Fibroproliferative Disorders

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surgical science 2016年第6期7卷 258-271页

作者： M. Georgina Uberti Yvonne N. Pierpont Rajat Bhalla Karan Desai Martin C. Robson Wyatt G. Payne Institute for Tissue Regeneration Repair & Rehabilitation Bay Pines V.A. Healthcare System Bay Pines USA Division of Plastic surgery University of South Florida Tampa USA

The various fibroproliferative disorders affecting humans have in common excess fibroblast activity and persistent overexpression or dysregulated activity of transforming growth factor beta (TGF-β). Cancer has many similar characteristics. Antineoplastic drugs can downregulate fibroblast activity and cytokine growth factors. This study evaluates the effect of six antineoplastic drugs on keloid and dupuytren’s disease fibroblasts. Keloid, normal scar, dupuytren’s affected palmar fascia, and normal palmar fascia fibroblasts were grown and seeded into Fibroblast Populated Collagen Lattices (FPCLs). The FPCLs were treated with one of six antineoplastic drugs or left untreated as controls. At 7 days, supernatants were extracted from all FPCLs and assayed for expression of Transforming Growth Factor beta (TGF)-βsub>1sub> and TGF-βsub>2sub>. All six antineoplastic drugs significantly inhibited FPCL contraction in both fibroproliferative conditions compared with the untreated controls (p βsub>1sub> and TGF-βsub>2sub> expression was downregulated in the supernatants of all FPCLs by the drug exposure. Cytotoxicity did not occur in these studies and was not the reason for the results. Although antineoplastic drugs can have significant side effects when given systemically, these results may be minimized when given to small areas involved in fibroproliferative scarring or when given topically or intralesionally. These in vitro results suggest that antineoplastic drugs may have a utility for treating various fibroproliferative disorders and warrant further investigation.

关键词： scar Fibroblasts Antineoplastic Drugs Fibroproliferative Disorders dupuytren’s disease Keloid

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