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Azithromycin in a triple therapy for *** eradication in active duodenal ulcer

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World Journal of Gastroenterology 2002年第5期8卷 879-882页

作者： Vladimir T.Ivashkin Tatiana L.Lapina Oksana Yu.Bondarenko Olga A. Sklanskaya Petr Va.Grigoriev Yuri V.Vasiliev Emilia P.Yakovenko Pavel V.Gulyaev Valeri I.Fedchenko V.Vasilenko Clinic of internal diseases gastroenterology and hepatology of the Moscow Sechenov Medical Academy119881 Pogodinskaya 5MoscowRussia Pathology Department of the Moscow Sechenov Medical Academy 119881Trubetskaya 8MoscowRussia Gastroenterological Center of the Health Ministry of Russia 105203N.Pervomayskaya ul.70MoscowRussia Central Institution of Gastroenterology 111123Sh.Entusiastov 86MoscowRussia

AIM:To assess and compare the efficacy and safety of two triple regimes:A)metronidazole,amoxicillin and omeprazole, which is still widely used in Russia,and B)azithromycin, amoxicillin and omeprazole in healing active duodenal ulcer and *** eradication. METHODS:100 patients with active duodenal ulcer were included in the open,multicentre,randomized study with comparative *** were randomly assigned to one of the following one-week triple regimes:A) metronidazole 500 mg bid,amoxicillin I g bid and omeprazole 20 mg bid(OAM,n=50)and B)azithromycin 1 god for the first 3 days(total dose 3 g),amoxicillin 1 g bid and omeprazole 20 mg bid(OAA,n=50).Omeprazole 20 mg od was given after the eradication course as a monotherapy for three *** control endoscopy was performed 8 weeks after the *** was determined in the entry of the study and four weeks after the cessation of treatment by means of histology and CLO-test. RESULTS:97 patients completed the study according to the protocol(1 patient of the OAM group did not come to the control endoscopy,2 patients of the OAA group stopped the treatment because of mild allergic urticaria).duodenal ulcers were healed in 48 patients of the OAM group(96 %, C190.5-100 %)and in 46 patients of the OAA group(92 %, CI 89.5-94.5 %)(p=ns).*** was eradicated in 15 out of 50 patients with OAM(30 %,CI 17-43 %)and in 36 out of 50 patients treated with OAA(72 %;CI 59-85 %) (P<0.001)-ITT ***: The triple therapy with omeprazole, amoxicillin and metronidazole failed to eradicate ***'vc\ the majority of patients, which is an essential argument to withdraw this regimen out of the national recommendations. Macrolide with amoxicillin are preferable to achieve higher eradication rates. Azithromycin (1 g od for the first 3 days) can be considered as a successful component of the triple PPI-based regimen.

关键词： Helicobacter pylori Adolescent Adult Aged Amoxicillin dosage Anti-Bacterial Agents Anti-ulcer Agents Azithromycin Comparative Study Drug Therapy, Combination duodenal ulcer Female Helicobacter Infections Humans Male Metronidazole Middle Aged Omeprazole Penicillins Research Support, Non-U.S. Gov't Treatment Outcome

Comparison of esomeprazole enteric-coated capsules vs esomeprazole magnesium in the treatment of active duodenal ulcer: A randomized, double-blind, controlled study

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World Journal of Gastroenterology 2008年第12期14卷 1941-1945页

作者： Xiao-Yan Liang Qing Gao Neng-Ping Gong Li-Ping Tang Pi-Long Wang Xiao-Hong Tao Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016 China

AIM： To evaluate the efficacy and tolerability of two different preparations of esomeprazole in healing duodenal ulcers. METHODS： A total of 60 patients with active duodenal ulcers were enrolled and randomized to receive esomeprazole enteric-coated capsules （40 mg） or esomeprazole magnesium （40 mg）, once daily, for 4 consecutive wk, with ulcer healing being monitored by endoscopy. Safety and tolerability were also assessed. RESULTS： Fifty seven patients completed the whole trial. The ulcer healing rates at the end of wk 2 were 86.7% and 85.2% in the esomeprazole enteric-coated capsules and esomeprazole magnesium groups, respectively （P = 0.8410）, and reached 100% at the end of wk 4 in beth groups. Symptom relief at the end of wk 2 was 90.8% in the esomeprazole enteric-coated capsules group and 86.7% in the esomeprazole magnesium group （P = 0.5406）; at the end of wk 4 symptom relief was 95.2% and 93.2%, respectively （P = 0.5786）. Adverse events occurred in 16.7% of the esomeprazole entericcoated capsules group and 14.8% of the esomeprazole magnesium group （P = 1.0000）. CONCLUSION： The efficacies of esomeprazole entericcoated capsules and esomeprazole magnesium in healing duodenal ulcer lesions and relieving gastrointestinal symptoms are equivalent. The tolerability and safety of beth drugs were comparable.

关键词： Esomeprazole duodenal ulcer Proton pumpinhibitor

Association of the myeloperoxidase ^(468)G→K polymorphism with gastric inflammation and duodenal ulcer risk

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World Journal of Gastroenterology 2005年第18期11卷 2796-2801页

作者： Ping-IHsu Jyh-JenJwo Hui-HwaTseng Kwok-HungLai Gin-HoLo Ching-ChuLo Chung-JenWu Seng-KeeChuah II-RanHwang Jin-LiangChen Yu-ShanChen AngelaChen DivisionofGastroenterology DepartmentofInternalMedicineKaohsiungVeteransGeneralHospitalNationalYang-MingUniversityKaohsiungTaiwanChina DepartmentofPathology KaohsiungVeteransGeneralHospitalNationalYang-MingUniversityKaohsiungTaiwanChina AngelaChen InstituteofBiomedicalSciencesNationalSunYat-SenUniversityKaohsiungTaiwanChina DepartmentofInternalMedicine KaohsiungChangGungMemorialHospitalKaohsiungTaiwanChina DepartmentofInternalMedicine DankookUniversityHospitalSouthKorea DepartmentofHealthCareandHospitalAdministration Chia-NanUniversityofPharmacyandScienceTainanTaiwanChina

AIM: To elucidate the relations between the myeloperoxidase ^(-468)G→a polymorphism and the development of duodenal ulcer (DU), and to investigate the impacts of this host genetic polymorphism on the histopathological features of Helicobacter pylori (H py/ori)-related gastritis. METHODS: In a case-control study of 115 consecutive DU patients and 182 controls, the myeloperoxidase ^(-468)G→A polymorphism was genotyped. Additionally, gastric mucosal changes were examined according to the updated Sydney System. RESULTS: The two study groups differed in the distributions of myeloperoxidase genotypes (P=0.008). All six individuals carrying myeloperoxidase A/A genotypes were in the DU group. The carriage of myeloperoxidase allele A and H pylori infection were associated with an increased risk of DU with odds ratios (OR) of 2.3 and 5.8, respectively. The combined risk of the carriage of myeloperoxidase allele A and H pylori infection for DU was 8.7 (95% CI, 3.5-21.8). In the H pylori-infected individuals, allele A carriers displayed higher bacterial density scores (P=0.04) in the antrum than did non-carriers. CONCLUSION: This work verifies for the first time the association of myeloperoxidase ^(-468)G→A polymorphism with antral H pylori density and DU disease. The mechanisms underlying this genetic polymorphism in developing DU disease merit further investigations.

关键词： duodenal ulcer Helicobacter pylorr Myeloperoxidase Polymorphism

Efficacy Observation on Yunnan Baiyao (云南白药) Combined with Antibiotics in Treating Helicobacter Pylori Related duodenal ulcer

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Chinese Journal of Integrative Medicine 2001年第1期7卷 36-38页

作者：黎红光李金庚 Tongcheng County Hospital Hubei

Objective: To observe the clinical efficacy of Yunnan Baiyao (云南白药, YNBY) combined with antibiotics in treating Helicobacter pylori (HP) related duodenal ulcer (DU). Methods: Eighty two HP positive DU patients were randomly divided into two groups: Treated group (44 cases) used YNBY plus amoxicillin and metronidazole; control group (38 cases) used de nol plus amoxicillin and metronidazole). Results: After a 2 week treatment course, the effect of epigastric pain relief was 68.3% in treated group, and 44.4% in control group, the difference between them was significant ( P <0.05). Marked effect in acid regurgitation and belching relief was observed in both groups. The rate of DU healing in treated and control group was respectively 88.6% and 89.5%; the clearance of HP 84.1% and 89.5%; and the side effects 4.5% and 13.5%, with insignificant difference between these two groups. Conclusion: YNBY combined with antibiotics in treating DU, and clearance of HP is an economic, safe and effective therapy.

关键词： duodenal ulcer helicobacter pylori Yunnan Baiyao antibiotics

Observation on 105 Cases of duodenal Bulbar ulcer Treated by Combined Therapy of Catgut Embe0ding and Chinese Drugs

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Journal of Traditional Chinese Medicine 2001年第2期21卷 111-115页

作者：范兆金 Acupuncture Department The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou510405

duodenal bulbar ulcer is a frequently encountered disease. Clinically, it manifests itself by regular epigastric pain accompanied by belching and acid regurgitation, corresponding to epigastralgia and stomach distending pain in traditional Chinese medicine (TCM). Based on the TCM type-differentiation, the author has treated 105 cases of duodenal bulbar ulcer by the combined therapy of catgut embedding at point Zusanli (ST 36) and Chinese drugs with satisfactory results. A summary is as follows. Clinical Data1. Case selection: The cases selected all had the clinical symptoms and signs of duodenal bulbar ulcer, and had been diagnosed by GI examination at this or other hospitals with no obvious therapeutic effects obtained after relevant treatment, and still symptoms and signs and repeated attacks of pain.

关键词： Absorbable Implants Adult Catgut Drugs, Chinese Herbal duodenal ulcer Female Humans Male Middle Aged

Endoscopic biopsy:duodenal ulcer penetrating into liver

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World Journal of Gastroenterology 2005年第21期11卷 3329-3329页

作者： Baybora Kircali Tülay Saricam Aysegul Ozakyol Eser Vardareli Medical Faculty Osamangazi University Fakultesi 26100Turkey

TO THE EDITORWe have read with interest the recent report by E Kayacetin and S Kayacetin of Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy[1] since we diagnosed the duodenal ulcer which penetrated into liver similarly. This is a rather unusual case because of the fifth case in the literature and responding to medical therapy.

关键词： Endoscopic biopsy duodenal ulcer

Observation of the Effect of Triple Therapy on duodenal ulcer with HP Posity

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Wuhan University Journal of Natural Sciences 1999年第3期4卷 340-340页

作者： Xu Lian-gan Shen Zhi-xiang Hospital of Wuhan University Wuhan China First Affiliated Hospital of HuBei Medical University Wuhan China

Thirty-foar cases of duodenal ulcer with Hp osity weve treated with Ompeperazole, Amoxi-cillin and Tindazole, which were compared with 34 cases of Hp positive duodenal ulcer treated with omeperazole only. The duration of treatment were both one week and all the patients were re-examed at one month after treatment. The result showed that the huring rate of ulcers (HRU) in triple therapy group was 88. 2%, uhile that of the contr group was 82. 3%. No significant difference was observed in the two groups (p>0.05). Hp eradication rate (HER) in triple therapy group was 91. 7%, while that of the control group was 41. 1 %. There was significant difference between the HERs of the two gronps (pulcers in 44 cases hared, with huring rate of 97. 8%. In the 23cases without Hp eradication, ulcers in 14 cases hured, with huring rate of 60. 9%. There was significant difference between these two gronps (p<0.05), which suggested the significant improvement of HRU of-ter Hp eradication. The triple therapy has the advantages such as high HRU, high rate of tolerance and no severe side effects. The therapy deserve recomrnendation clinically.

关键词： tripe therapy helicobacter pylori duodenal ulcer

Efficacy of ilaprazole in the treatment of duodenal ulcers:A meta-analysis

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World Journal of Gastroenterology 2014年第17期20卷 5119-5123页

作者： Xi-Qing Ji Jun-Feng Du Gang Chen Guang Chen Bo Yu Department of General Surgery General Hospital of Beijing Military Command of People’s Liberation Army

AIM: To compare the efficacy and tolerance of ilaprazole compared with other proton pump inhibitors (PPIs) in the treatment of duodenal ulcer.

关键词： Ilaprazole Proton pump inhibitor duodenal ulcer Meta-analysis

Patients with Helicobacter pylori positive and negative duodenal ulcers have distinct clinical characteristics

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World Journal of Gastroenterology 2005年第23期11卷 3518-3522页

作者： Kent-Man Chu Ka-Fai Kwok Simon Law Kam-Ho Wong Department of Surgery

AIM: To assess the clinical characteristics of Helicobacterpylori(H pylori) negative duodenal ***: Patients with an endoscopic diagnosis of duodenal ulcer between 1996 and 2002 were included in the present study. Patients were considered to be negative for Hpylori, if both histological examination and rapid urease test of biopsy specimens were negative. A comparison was made between patients with H pyloripositive and negative duodenal ***: A total of 1 343 patients were studied. Their mean age was 54.7±0.5 years. There was a male preponderance (M:F = 2.5:1). Three hundred and ninetyeight patients (29.6%) did not have H pylori infection. The annual proportion of patients with H pylori negative duodenal ulcers increased progressively from 1996 to2002. On multivariate analysis, patients with H pylorinegative duodenal ulcer were more likely to be older, have concomitant medical problem, pre-existing malignancy, recent surgery, underlying sepsis, or taken non-steroidal anti-inflammatory drugs. In terms of clinical presentations, patients with H pylori negative duodenal ulcer were more likely to present with bleeding, multiple ulcers and larger ***: The proportion of patients with H pylori negative duodenal ulcers is on the rise because of a continued drop in incidence of H pylori positive duodenalulcers in recent years. Such patients have distinct clinical characteristics and it is important to ascertain the H pylori status before starting eradication therapy.

关键词： Helicobacter pylori duodenal ulcer