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第十七届中国体视学与图像分析学术会议

作者：张文文 WAN Luping 孙保华赵维 Department of Medical Physics School of Physics at Beihang University

Compared to conventional single-energy ct(SEct),dual-energy ct(DEct) allows differentiation and quantification of different tissues and can be used for a wide spectrum of emerging clinical *** providing innumerable benefits,DEct has not been widely used yet,especially in less-developed region,mainly because of its ***,some deep learning-based approaches have been devoted to perform DEct imaging from easily available *** we propose an augmented attention U-Net which includes weight map generator and DEct imaging module to generate DEct images using standard SEct *** weight map generator provides pixel-level weights according to the features extracted from *** imaging module encompasses a classical U-Net and several augmented attention *** weight maps as input,the augmented attention gates can assist U-Net to focus on region of interest(ROI) to reduce the inference of ct noise in non-denoised *** performance of our approach was studied using images from patients who received contrast-enhanced abdomen DEct scan with popular DEct applications:virtual non-contrast(VNC) imaging and contrast *** relevant metrics were used for quantitative *** absolute HU difference between the original high-energy ct(HEct) images generated from DEct scan and the predicted ones by our method are2.6 HU,2.4 HU,2.0 HU,0.4 HU and 2.9 HU for the ROIs on heart,aorta,spine,liver and kidney,*** addition,comparing our method with the state-of-the-art deep learning-based DEct imaging method,we find that the distribution of ROI’s ct value predicted by our method are closer to ground truth,showing the merit of the proposed *** premise of the approach is that DEct can be attained without any additional measurement than a SEct *** technique provides a simple and costeffective solution for modern DEct clinical applications.

关键词： dual-energy ct Single-energy ct Deep learning Attention

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A study on noise reduction for dual-energy ct material decomposition with autoencoder

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Radiation Detection Technology and Methods 2019年第3期3卷 209-221页

作者： Mohan Li Zhe Wang Qiong Xu Zhidu Zhang Zhiwei Cheng Shuangquan Liu Baodong Liu Cunfeng Wei Long Wei Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Purpose A major challenge for the material decomposition task of the dual-energy computed tomography(DEct)is the algorithm often suffers from heavy noise in the *** purpose of this study is to propose a scheme to increase the noise performance of material *** The scheme we propose in this paper is to apply an autoencoder-based denoising procedure to the photon-counting DEct images before they are fed into the material decomposition *** implement the autoencoder(AE)by stacking a series of convolutional and deconvolutional *** decomposition technique adopted in our work is an iterative method using least squares estimation with the Huber loss *** noises of the input and the output of material decomposition are analyzed with both simulated data and real *** and chicken wing experiments are conducted with a photoncounting-based spectral ct scanner to evaluate the proposed material decomposition *** The noise analysis of the input and the output of material decomposition demonstrates a positive correlation between *** experiment indicates a noise reduction in the output density maps for 26.07%to 35.65%after the autoencoder pre-processing is *** resultant contrast-to-noise ratio is largely increased,*** By utilizing the additional autoencoder denoising step,the material decomposition algorithm achieves an improvement in the noise performance of the resultant density maps.

关键词： dual-energy ct Material decomposition Noise reduction Autoencoder Photon counting

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Diagnostic Value of dual-energy ct in Differentiating Malignant and Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

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Journal of Biosciences and Medicines 2021年第4期9卷 54-76页

作者： Kunlin Ye Yongyao Kuang Jianye Liang Xi Xu Changzheng Shi Qingqing Cheng Zijie Jiang Ziyun Xiang Liangping Luo Department of Medical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou China Department of Medical Imaging Longgang District People’s Hospital of Shenzhen Shenzhen China Department of Medical Imaging Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China

Objectives: To evaluate the diagnostic performance of the quantitative iodine parameters, including Iodine Concentration (IC), Normalized Iodine Concentration (NIC), and λHU, in distinguishing malignant and benign thyroid nodules. Methods: Relevant studies were searched from Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure database and other complementary sources from inception to May 20, 2020. Study selection, data extraction, quality assessment, and data analyses were performed following the Cochrane standards and the PRISMA-DTA guideline. Results: Eight studies were included (595 patients with 737 thyroid nodules). The pooled sensitivity, specificity and summary diagnostic odds ratio of IC were 79% (95% CI: 69% - 86%), 76% (95% CI: 65% - 84%) and 11 (95% CI: 5 - 27) respectively;those of NIC were 78% (95% CI: 70% - 85%), 80% (95% CI: 74% - 85%) and 15 (95% CI: 9 - 24) respectively;those of λHU were 80% (95% CI: 71% - 87%), 77% (95% CI: 70% - 83%) and 14 (95% CI: 8 - 24) respectively. Conclusion: DEct can be a potential evaluation tool for thyroid nodules. The NIC may be the most sensitive iodine parameter and could be comparable between different DEct machines in thyroid nodule assessment.

关键词： Thyroid Nodules Differential Diagnosis dual-energy ct Iodine Concentration Meta-Analysis

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Urate crystals deposition in the feet of overweight juveniles and those with symptomatic hyperuricemia:A dual-energy ct study

Urate crystals deposition in the feet of overweight juvenile...

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2016年浙江省风湿病学学术年会暨风湿免疫病诊疗进展学...

作者：狄亚珍孙楠宁波市妇女儿童医院小儿风湿免疫科

Background The present study evaluated the clinical value of dual-energy computed tomography(DEct)for detecting urate crystals in juveniles with symptomatic *** We recruited 24 juveniles(15 male and 9 female)who presented with symptomatic *** mean body mass index(BMI)was 26.4 kg/m(standard deviation,SD 11.3 kg/m).Fifteen juveniles(71.4%)were *** scans of the feet were *** post-processing,a color-coding gout software protocol was *** Urate crystals deposition was observed in 21/24(87.5%)juveniles with symptomatic *** crystals were detected in or around the anatomic site included the first metatarsophalangeal(MTP)joints(5/24,20.8%);the calcaneus(5/24,20.8%);any other toe joints(3/24,12.5%);the astragalus(3/24,12.5%);the ankle joints(3/24,12.5%);the metatarsals(2/24,8.3%);the cuboid(1/24,4.2%);and other parts of the feet(2/24,8.3%).Importantly,urate crystals deposition weas located in the soft tissue(tendon/tendon insertion sites/entheses)around the above-mentioned sites in a majority of these *** Urate crystals deposition can be detected by dual-energy ct in the feet of symptomatic hyperuricemia *** can be a valuable diagnostic tool for helping diagnose in juvenile gout.

关键词： children dual-energy ct hyperuricemia jointdamage urate crystals

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Urate crystal deposition in hyperuricemia children: a dual energy ct study

Urate crystal deposition in hyperuricemia children: a dual e...

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浙江省免疫学会第六次会员代表大会暨第十一次学术大会

作者：应倩倩王佳佩李蕴言孙楠狄亚珍沈梦娇傅诗薇宁波大学医学院宁波市妇女儿童医院小儿风湿免疫科天津市儿童医院小儿免疫科

Objective:The incidence of hyperuricemia(HUA)at younger ages is increasing along the coastal regions of *** study aimed to compare the frequency of dual energy ct(DEct)urate crystal deposition between symptomatic hyperuricemic children and asymptomatic hyperuricemic ***:56 hyperuricemic children were divided into Joint Group(n=33)and Asymptomatic Group(n=23)according to whether they had a history of arthritis symptoms,which includes rapid onset monoarthritis with intense pain and *** analyzed DEct scans of their feet from the Joint Group and the Asymptomatic Group and compared their clinical ***:DEct urate deposits were observed in 28/33(84.8%)children with symptomatic HUA,14/23(60.9%)with asymptomatic *** found 60 areas of urate deposition in the Joint Group;DEct urate crystal deposition was most frequently observed in the first metatarsophalangeal(MTP)joint(30.0%),ankle joint(15.0%),-and calcaneus(13.3%).39 urate deposits were found in Asymptomatic Group;DEct urate crystal deposition was most frequently observed in calcaneus(25.6%),the first MTP joint(17.9%),and the first phalanx(15.4%).Conclusions:Urate deposition can occur in children with HUA,and these deposits occur more frequently in hyperuricemic children with a history of arthritis ***,the urate deposition in the first MTP joint and calcaneus was more prevalent than in other *** is important to give more attention to hyperuricemic children.

关键词： Hyperuricemia Children dual-energy ct Urate crystal Joint injury

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dual-energy Computed Tomography for the Diagnosis of Urethral Foreign Body: A Case Study

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Open Journal of Urology 2022年第8期12卷 421-426页

作者： Koukichi Murakami Isao Kuroda Go Nagao Kanta Fukusima Naohiro Kamoda Gen Arai Teiichiro Aoyagi Department of Urology Tokyo Medical University Ibaraki Medical Center Ibaraki Japan Department of Urology Tokyo Medical University Hospital Tokyo Japan Department of Radiology Tokyo Medical University Ibaraki Medical Center Ibaraki Japan

Foreign body insertion in the urethra and bladder is not uncommon and has been reported in many studies to date. However, since foreign bodies are often accidentally introduced into the urethra and bladder during masturbation, they take a variety of shapes and sizes. Furthermore, patient self-reports are typically unreliable as many patients feel ashamed;thus, appropriate preoperative diagnosis is critical. Diagnosis of foreign body insertion in the urethra and bladder is performed using imaging modalities such as abdominal X-ray and computed tomography (ct). However, single-energy ct (SEct) is not sufficient in detecting foreign bodies in some cases. In the present study, we report a successful preoperative identification of urethral foreign body in a patient using dual-energy ct (DEct).

关键词： dual-energy ct Urethral Foreign Body

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Application of dual-energy Computed Tomography for Breast Cancer Diagnosis

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第4期5卷 288-297页

作者： Yukiko Okamura Nobuko Yoshizawa Masaru Yamaguchi Ikuo Kashiwakura Department of Radiological Life Sciences Hirosaki University Graduate School of Health Sciences Hirosaki Japan Department of Diagnostic Radiology and Nuclear Medicine Hamamatsu University School of Medicine Hamamatsu Japan

The present study aimed to investigate the possibility of using dual-energy computed tomography (ct) before therapy to discriminate between normal breast tissue and tumor tissue in patients with breast cancer, without the need to use a contrast medium. The following patient data were extracted by interview and from the hospital’s radiology information system: height, weight, age, menstrual cycle, ct images of normal tissue and tumors with or without contrast medium, and the histopathological diagnosis of the aspiration biopsy. The median age of the 43 participants was 56 years (range, 30 - 80 years). The ct values were evaluated using a clinical analytical program based on the three-material decomposition technique. Breast cancer was classified into ductal carcinoma in situ, invasive ductal carcinoma, invasive lobular carcinoma, fibromatosis-like metaplastic carcinoma, and apocrine carcinoma. In all conditions, regardless of contrast medium, the ct values of tumor tissues were higher than those of normal breast tissue, indicating the effectiveness of dual-energy ct (DE-ct) in the diagnosis of breast cancer. By contrast, DE-ct showed limited potential for distinguishing ductal carcinoma in situ from invasive ductal carcinoma. There have only been a few reports regarding ct examination of breast cancer, and it is expected this study encourage the development of DE-ct imaging to improve tumor detection in patients with breast cancer.

关键词： Breast Cancer dual-energy ct ct Value Contrast Medium Oncological Imaging Ductal Carcinoma in Situ Invasive Ductal Carcinoma

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Correlation between Automated Quantification of Lung Perfusion Blood Volume (PBV) and Pulmonary Artery Pressure

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Open Journal of Radiology 2016年第2期6卷 105-112页

作者： Hirofumi Koike Eijun Sueyoshi Ichiro Sakamoto Akira Tsuneto Masataka Uetani Department of Cardiovascular Medicine Nagasaki University Hospital Nagasaki Japan Department of Radiology Nagasaki University School of Medicine Nagasaki Japan

Purpose: dual-energy ct (DEct) can be used for quantification of lung perfusion blood volume (PBV), allowing objective evaluation. However, no reports have investigated pulmonary perfusion correlating with pulmonary artery pressure (PAP) in patients with chronic pulmonary diseases. The purpose was to evaluate automated quantification of the lung PBV using dual-energy ct, and its correlation with PAP. Methods: 274 patients who underwent echocardiography within two weeks also underwent ct. The population was divided into high (≥40 mmHg) and low (ctively). We retrospectively eva-luated the lung PBV using Syngo software, and correlations between the lung PBV and estimated sPAP. Results: Lung PBV values were 25.0 ± 9.6 and 29.0 ± 9.3 Hounsfield units (HU) in high and low sPAP groups, respectively, with a significant difference between them (p = 0.003). In the high sPAP group with underlying lung diseases (n = 15), chronic thromboembolism (n = 25), pulmonary artery stenosis (n = 12), and left heart failure (n = 11), using the Dana Point classification system, lung PBV values were 18.6 ± 1.6, 25.1 ± 4.5, 25.8 ± 4.5, and 32.7 ± 9.4 HU, respectively. There were significant differences in quantification of the lung PBV among them. The mean sPAP of subjects with left heart failure was significantly higher than in the others. In subjects with left heart failure, a positive correlation between the lung PBV value and sPAP was noted (R = 0.721, p < 0.0001). Conclusions: Automated quantification of the lung PBV may estimate the high sPAP. The lung PBV may contribute to clarifying the etiology of a high PAP due to left heart failure.

关键词： dual-energy ct Lung Perfusion Blood Volume Pulmonary Hypertension Iodine Attenuation

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