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DUSP8 inhibits LPS-induced acute lung injury by regulating macrophage response

Life Research 2021年第3期4卷 55-63页

作者： Qing-Bao Xu Chen-Xi Tang Li He Wen Cheng Ping Jiang Xiao-Ya Wang Department of Emergency Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina Department of Nursing Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina Department of Neurology Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina Department of Critical Care Medicine Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina Department of Biochemistry and Psychopharmacology Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Neurosurgery Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina

Background:Although many studies focus on investigating the new therapeutic target of acute lung injury(ALI),there still needs more works on exploring the role of other molecular in the pathology of *** specificity phosphatase(DUSP)8 has been reported to participate in the process of ***,the potential role of DUSP8 in lipopolysaccharide(LPS)-induced murine ALI is still ***:Firstly,murine ALI was established by LPS treatment and further measured by hematoxylin-eosin ***,the expression of DUSP8 in lung tissues was analyzed by real-time polymerase chain ***,DUSP8 overexpression vector was utilized and the protein level of DUSP8 was detected by western ***,the pathologic injury was measured by hematoxylin-eosin staining and wet/dry ***,we cultured bone-marrow-derived macrophages and detected the expression of DUSP8 by real-time polymerase chain reaction and western blot after LPS *** addition,DUSP8 overexpression vector was transfected into bone-marrow-derived macrophages and the levels of related inflammatory cytokines were measured by enzyme-linked immunosorbent ***:Compared with the control mice,DUSP8 significantly decreased in LPS-induced murine ***,DUSP8 overexpression could attenuate the pathology of ALI by altering lung inflammation and ***,DUSP8 was also reduced in LPS-treated BMDM and reached a peak at ***,DUSP8 overexpression could reduce the productions of related inflammatory cytokines,such as interleukin-1β,tumor necrosis factor-αand interleukin-6 in LPS-treated bone-marrow-derived ***:DUSP8 is reduced in LPS-induced murine acute lung injury and DUSP8 overexpression could ameliorate the pathologic injury of ALI by altering macrophage inflammation responses.

关键词： dual specificity phosphatase 8 Acute lung injury Inflammation Macrophage

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