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BONE MINERAL ANALYSIS OF WHOLE BODY IN 292 NORMAL SUBJECTS ASSESSED BY dual x-ray absorptiometry

Chinese Medical Sciences Journal 2003年第2期18卷 97-99页

作者：秦明伟余卫徐苓田均平邢小平孟迅吾 Department of Radiology Reking Union Medical College HospitalCAMS & PUMCBeijing 100730

Objective. To study the whole body bone mineral changes in normal ***. Bone mineral was measured by dual x-ray absorptiometry(DxA) in 292 normal subjectsaged 10～79 years, including 152 females and 140 males. They were divided into age-groups by ***. In males, the ages with peak value of total bone mineral content (TBMC), total bone min-eral density (TBMD), anteroposterior spine BMD(L2-4 BMD) were in the 30～39,20～39, 20～29 age-groups respectively. In females, they were all in the 30～39 age-group. Peak values of TBMC, TBMD,L2-4 BMD were higher in males than those in females. Loss of bone mineral for females was more pro-nounced than that for males. Loss of L2-4 BMD was more pronounced than ***. This study provides the normal bone mineral data of whole body for males and females,and the characteristic of changes.

关键词： osteoporosis bone density dual x-ray absorptiometry whole body

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Assessment of bone marrow changes in postmenopausal women with varying bone densities： magnetic resonance spectroscopy and diffusion magnetic resonance imaging

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Chinese Medical Journal 2010年第12期123卷 1524-1527页

作者： LIU Yong TANG Guang-yu TANG Rong-biao PENG Yi-feng LI Wei Department of Radiology Affiliated Tenth People's Hospital of Tongji University Shanghai 200072 China

Background Recent studies suggest that bone marrow adipose tissue might play a role in the pathogenesis of osteoporosis. There are inconsistent findings on the relationship among marrow fat content, bone mineral density and apparent diffusion coefficient （ADC）. This study aimed to prospectively explore the efficacy of MR spectroscopy （MRS） and diffusion-weighted MR imaging （DWl） in detecting vertebral marrow changes in postmenopausal women with varying bone densities. Methods Both MRS and DWl of the lumber spine were performed in 102 postmenopausal women （mean age, （67.3±6.5） years; range, 55-83 years）, who underwent dual x-ray absorptiometry. Marrow fat content and ADC were compared and correlated among three groups： 24 with normal bone density, 31 with osteopenia and 47 with osteoporosis. Results Vertebral marrow fat content was significantly increased in the osteoporotic group （（65.60±7.68）%, P 〈0.001） and the osteopenic group （（57.68±6.45）%, P 〈0.001）, when compared with the normal bone density group （（51.67±3.27）%）. ADC values were significantly decreased in the osteoporotic group （（0.39±0.03）×10^-3mm^2/s, P 〈0.001） and in the osteopenic group （（0.42±0.02）×10^-3mm^2/s, P 〈0.001）, when compared with the normal bone density group （（0.47±0.03）×10^-3mm^2/s）. The marrow fat content negatively correlated with both bone density （r=-0.731, P 〈0.001） and marrow ADC （r=-0.572, P 〈0.001）. The bone density positively correlated with the ADC values （r=0.802, P 〈0.001）. Conclusions Postmenopausal women experience a corresponding increase in vertebral marrow fat content as the bone density decreases. Marrow fat content and ADC correlate to the bone density. MRS and DWl may indirectly assess the early bone marrow changes in postmenopausal women.

关键词： osteoporosis 1H MRS diffusion weighted imaging bone marrow dual x-ray absorptiometry

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Competitive trampolining influence trabecular bone structure,bone size,and bone strength

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Journal of Sport and Health Science 2016年第4期5卷 469-475页

作者： Lauren A.Burt John D.Schipilow Steven K.Boyd Department of Radiology Faculty of MedicineMcCaig Institute for Bone and Joint HealthUniversity of Calgary

Background：Trampolining is a form of gymnastics that has increased in popularity over the last decade and due to its concurrence with the formative years of bone development,it may have an important impact on bone ***,bone density,microarchitecture,and bone strength of competitive trampolinists have not been ***,the purpose of this cross-sectional study was to investigate the relationship between trampolining participation and（1） bone density,area,and microarchitecture;and（2） estimated bone strength and the role of muscle and impact loading in young female ***：We recruited 29 female participants aged 16–29 years for this study（n=14 trampolinists;n=15 controls）.Skeletal parameters were assessed using dual x-ray absorptiometry,high-resolution peripheral quantitative computed tomography（HR-pQCT）,and finit element analysis（FEA）.Muscle strength was measured using ***：Trampolinists had higher bone density at the hip and spine,greater trabecular density and thicker trabeculae at the tibia,as well as larger bones at both the tibia and radius than controls（p〈0.05）.Trampolinists also had higher muscle strength than controls at the lower body with no difference between groups in the upper *** of bone strength using FEA were greater for trampolinists than controls at both the radius and ***：This is the firs study to investigate bone density,area,and microarchitecture in female trampolinists using HR-p *** had greater bone density,area,microarchitecture,and estimated bone strength than controls.

关键词： dual x-ray absorptiometry Finite element analysis Gymnastics High-resolution peripheral quantitative computed tomography Muscle strength Trampolining

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Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 44-54页

作者： Suprabhat Giri Prajna Anirvan Sumaswi Angadi Ankita Singh Anurag Lavekar Department of Gastroenterology and Hepatology Kalinga Institute of Medical SciencesBhubaneswar 751024OdishaIndia Department of Gastroenterology Kalinga Gastroenterology FoundationCuttack753001OdishaIndia Department of Gastroenterology Nizam’s Institute of Medical SciencesHyderabad 500082TelanganaIndia Department of Gastroenterology Seth GS Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sagar HospitalBengaluru 560041KarnatakaIndia

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced ***,characterized by decreased muscle strength and mass,shares common pathophysiological traits with *** association exists between sarcopenia and increased NAFLD ***,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain *** To analyze the prevalence and outcomes of sarcopenia in patients with *** We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June *** included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse *** also used the Newcastle-Ottawa scale for quality *** Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for *** was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such *** in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and *** This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD *** variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent *** review demonstrates the multidimension

关键词： Non-alcoholic fatty liver disease Sarcopenia Hepatic fibrosis Low muscle mass Hand grip strength Bioelectric impedance analysis dual x-ray absorptiometry

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