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dry eye disease in systemic lupus erythematosus: a cross sectional study

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1255-1261页

作者： Sui-Fang Kang Ying-Xue Wang Qi-Chen Zhang Zhi-Lun Wang Guo-Ling Chen Department of Ophthalmology the Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Department of Rheumatology the Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina

AIM:To explore ocular surface manifestations of dry eye disease(DED)and its influencing factors in systemic lupus erythematosus(SLE)***:Ophthalmological examinations were conducted in SLE patients(n=43)and controls(n=41),including Ocular Surface disease Index(OSDI),objective scatter index(OSI),tear meniscus height(TMH),lipid layer thickness(LLT),non-invasive Keratograph tear breakup time(NIKBUT),corneal fluorescein score(CFS),Schirmer I *** was diagnosed according to the Tear Film and Ocular Surface Society dry eye Workshop II *** patients were further divided into DED group and non-DED group,the disease activity,clinical manifestations and laboratory investigations were compared between the two *** disease activity was evaluated by Systemic Lupus Erythematosus disease Activity Index 2000(SLEDAI-2K).Receiver operative characteristic(ROC)curve and multiplefactor binary logistic regression were ***:SLE patients showed higher OSDI[9.1(2.8-15.9)vs 6.3(2.2-7.5),P=0.035],higher OSI[1.67(1.09-2.60)vs 0.96(0.87-1.60),P=0.001],higher CFS[1(0-2)vs 0(0-1),P=0.001],lower LLT[65(42-100)vs 100(79.5-100),P=0.010],and lower NIKBUT[8.03(4.02-9.73)vs 9.67(5.26-12.71),P=0.030]than *** 32.6%of SLE patients had DED,which was higher than 12.2%of healthy *** group showed higher SLEDAI-2K score[9.7±6.1 vs 5.4±3.4,P=0.025],higher anti-cardiolipin antibody(ACL)[8.7(3.5-13.2)vs 3.6(2.0-6.9),P=0.035],and higher proportion of patients with cutaneous eruption[42.9%vs 6.9%,P=0.015]than non-DED *** to multiple-factor binary logistic regression analysis,the SLEDAI-2K score(OR=1.194,P=0.041)and cutaneous eruption(OR=7.094,P=0.045)could be consider as risk factors for DED in SLE *** ROC curve of the combined factors including age,disease duration,SLEDAI-2K score,ACL,and cutaneous eruption was analyzed,with a sensitivity of 0.786,a specificity of 0.793,and an area under curve of ***:Ocular surface affec

关键词： autoimmune disease systemic lupus erythematosus dry eye disease

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Dual‑Atom Nanozyme eye Drops Attenuate Inflammation and Break the Vicious Cycle in dry eye disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： Dandan Chu Mengyang Zhao Shisong Rong Wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang Jingguo Li Henan eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual *** incidence of DED is gradually increasing with the highfrequency use of electronic *** inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from ***,current therapies merely targeting inflammation show the failure of DED ***,a novel dual-atom nanozymes(DAN)-based eye drops are *** antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic *** in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell ***,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious *** findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

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Evaluation of dry eye disease symptomatology and mental health status among patients with different COVID-19 statuses

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 822-830页

作者： Fang Ruan Wen-Jun Kong Qian Fan Hong-Wei Dong Wei Zhang Wen-Bin Wei Ying Jie Department of Ophthalmology Beijing You’an HospitalCapital Medical UniversityBeijing Infectious Eye Disease Diagnosis and Treatment CenterBeijing 100069China Beijing Tongren eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Ophthalmology and Visual Sciences Key LabBeijing 100730China Tianjin eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteNankai University Affiliated Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300020China

AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 ***:A cross-sectional observational design was *** 123 eligible adults(46.34%of men,age range,18-59y)with COVID-19 included in the study from August to November,*** Surface disease Index(OSDI),Five-item dry eye Questionnaire(DEQ-5),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI)were used in this ***:OSDI scores were 6.82(1.25,15.91)in asymptomatic carriers,7.35(2.50,18.38)in mild cases,and 16.67(4.43,28.04)in recurrent cases,with 30.00%,35.56%,and 57.89%,respectively evaluated as having DED symptoms(χ2=7.049,P=0.029).DEQ-5 score varied from 2.00(0,6.00)in asymptomatic carriers,3.00(0,8.00)in mild cases,and 8.00(5.00,10.00)in recurrent cases,with 27.50%,33.33%,and 55.26%,respectively assessed as having DED symptoms(χ2=8.532,P=0.014).The prevalence of clinical anxiety(50.00%)and depression(47.37%)symptoms were also significantly higher in patients with recurrent infection(χ2=24.541,P<0.001;χ2=30.871,P<0.001).Recurrent infection was a risk factor for high OSDI scores[odds ratio,2.562;95%confidence interval(CI),1.631-7.979;P=0.033]and DEQ-5 scores(odds ratio,3.353;95%CI,1.038-8.834;P=0.043),whereas having a fixed occupation was a protective factor for OSDI scores(odds ratio,0.088;95%CI,0.022-0.360;P=0.001)and DEQ-5 scores(odds ratio,0.126;95%CI,0.039-0.405;P=0.001).CONCLUSION:Patients with recurrent COVID-19 have more severe symptoms of DED,anxiety,and depression.

关键词： COVID-19 dry eye disease recurrent infection mental health

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dry eye disease among patients infected with the SARSCoV-2 Omicron variant:a cross-sectional study

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国际眼科杂志:英文版 2023年第10期16卷 1608-1615页

作者： Qi-Fang Chen Juan Yu Han Chu Pan Hu Li Chen Ting Liu Chong-Yi Li Department of Ophthalmology Daping HospitalThird Military Medical UniversityChongqing 400042China Center of Growth Metabolism and AgingKey Laboratory of Bio-Resources and Eco-EnvironmentCollege of Life SciencesSichuan UniversityChengdu 610064Sichuan ProvinceChina

AIM:To investigate the incidence of dry eye disease(DED)and relevant risk factors among patients infected with the severe acute respiratory syndrome coronavirus 2(SARSCoV-2)Omicron ***:This cross-sectional,observational analysis included 993 patients with corona virus disease 2019(COVID-19)treated at the National Exhibition and Convention Center(Shanghai)Fangcang Shelter Hospital,from April 10 to May 26,*** 944 uninfected control participants were *** participants completed ocular surface disease index(OSDI)questionnaires,and DED symptoms were determined using OSDI *** demographic characteristics,length of hospital stay and in nasopharyngeal swabs were performed using ***-CoV-2 Omicron variant infection was confirmed by nucleic acid-based detection in nasopharyngeal swabs using a 2019-nCoV nucleic acid detection *** risk factors for DED symptoms among patients with COVID-19 and control participants were determined by logistic regression ***:Patients with COVID-19 showed a higher incidence of DED than controls(64.9%vs 55.1%,P<0.001).SARS-CoV-2 infection[odds ratios(ORs)(95%CI):1.271(1.038,1.556)],use of contact lenses[ORs(95%CI):9.350(3.676,23.783)],history of corneal refractive surgery[ORs(95%CI):2.047(1.494,2.804)],poor sleep quality[ORs(95%CI):2.657(2.029,3.480)],and video display terminal(VDT)use for more than 8h per day[ORs(95%CI):6.348(4.720,8.538)]were found to be risk factors for DED symptoms in patients with COVID-19 as well as *** patients with COVID-19,the length of hospital stay[ORs(95%CI):1.196(1.134,1.262)],use of contact lenses[ORs(95%CI):20.423(2.680,155.632)],history of corneal refractive surgery[ORs(95%CI):2.166(1.321,3.553)],poor sleep quality[ORs(95%CI):3.650(2.381,5.597)],and VDT use for more than 8h per day[ORs(95%CI):7.740(4.918,12.180)]were significant risk factors for DED ***:Patients with COVID-19 are more prone to develop symptomatic ***-CoV

关键词： COVID-19 dry eye disease risk factors

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Acupuncture for the management of dry eye disease

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Frontiers of Medicine 2022年第6期16卷 975-983页

作者： Julia Prinz Nicola Maffulli Matthias Fuest Peter Walter Frank Hildebrand Filippo Migliorini Department of Ophthalmology RWTH Aachen UniversityPauwelsstr.3052074AachenGermany Department of Medicine Surgery and DentistryUniversity of SalernoVia S.Allende84081BaronissiSAItaly Queen Mary University of London Barts and the London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondonEI 4DGEngland School of Pharmacy and Bioengineering Keele University Faculty of MedicineThornburrow DriveStoke on TrentEngland Department of Orthopedics University Clinic AachenRWTH Aachen University Clinic52064AachenGermany

The effectiveness of using acupuncture for dry eye disease(DED)is ***,this systematic review investigated the effectiveness and feasibility of using acupuncture for DED in accordance with the 2020 PRISMA *** outcomes of interests were(1)to evaluate the efficacy of acupuncture in improving the ocular surface disease index(OSDI),Schirmer I test score,and tear breakup time from baseline to the last follow-up;(2)to determine possible complications of using acupuncture;and(3)to investigate the superiority of acupuncture over other commonly used treatments for *** from 394 patients were *** showed that acupuncture significantly prolonged the tear breakup time(P<0.0001),significantly increased the Schirmer I test score(P<0.0001),and significantly reduced the OSDI(P<0.0001)from baseline to the last *** with the control group,the acupuncture group had significantly greater Schirmer I test score(P<0.0001),significantly longer tear breakup time(P=0.0004),and significantly lower OSDI(P=0.002).These results suggest that acupuncture is effective and feasible in improving symptoms and signs of *** severe adverse effects of acupuncture were observed.

关键词： dry eye disease xerophthalmus acupuncture

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Inflammation and dry eye disease——where are we?

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 820-827页

作者： Srinivas K Rao Rishi Mohan Nikhil Gokhale Himanshu Matalia Paras Mehta Darshan eye Care&Surgical Centre ChennaiTamil NaduIndia MM eyetech Institute of Ophthalmology New DelhiIndia Gokhale eye Hospital MumbaiMaharashtraIndia Narayana Nethralaya Electronic CityBangaloreKarnatakaIndia Sameep eye Hospital and Corneal Center VadodaraGujaratIndia

The presence of inflammation in dry eye disease(DED)results in increased patient symptomatology,ocular surface damage and worsening tear *** also affects the health of meibomian glands and their secretions which further aggravates ocular surface *** article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED,inflammation and meibomian gland dysfunction(MGD).The clinical evaluation of eyes with such changes,markers that identify the presence of inflammation on the ocular surface and current treatment options are discussed.

关键词： dry eye disease inflammation meibomian gland dysfunction vicious cycle ocular surface disease

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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dry eye disease

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Frontiers of Medicine 2023年第4期17卷 781-795页

作者： Yu Han Yu Zhang Kelan Yuan Yaying Wu Xiuming Jin Xiaodan Huang eye Center The Second Affiliated HospitalZhejiang University School of MedicineZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhou 310009China

Tear film hyperosmolarity plays a core role in the development of dry eye disease(DED)by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface *** this study,the mechanisms involving the hyperosmolar microenvironment,glycolysis mediating metabolic reprogramming,and pyroptosis were explored clinically,in vitro,and in *** from DED clinical samples indicated that the expression of glycolysis and pyroptosis-related genes,including PKM2 and GSDMD,was significantly upregulated and that the secretion of IL-1βsignificantly *** vitro,the indirect coculture of macrophages derived from THP-1 and human corneal epithelial cells(HCECs)was used to discuss the interaction among *** hyperosmolar environment was found to greatly induce HCECs’metabolic reprogramming,which may be the primary cause of the subsequent inflammation in macrophages upon the activation of the related gene and protein expression.2-Deoxy-d-glucose(2-DG)could inhibit the glycolysis of HCECs and subsequently suppress the pyroptosis of *** vivo,2-DG showed potential efficacy in relieving DED activity and could significantly reduce the overexpression of genes and proteins related to glycolysis and *** summary,our findings suggested that hyperosmolar-induced glycolytic reprogramming played an active role in promoting DED inflammation by mediating pyroptosis.

关键词： dry eye disease glycolytic reprogramming pyroptosis inflammation 2-DG

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Rabbit models of dry eye disease: comparative analysis

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1177-1185页

作者： Vytautas Baranauskas Julija Daukantaitė Saulius Galgauskas Vilnius University Institute of Biochemistry Life Science CentreSauletekio av 7VilniusLT 10257Lithuania Vilnius University Faculty of Medicine M.K.Čiurlionio str.21VilniusLT 03101Lithuania

AIM:To report ocular changes in rabbits after the implementation of three different induction methods to create dry eye(DE)conditions and provides evidence of DErelated disease ***:Experimental methods were divided into 3 *** first model used involved triple injection of complete Freund’s adjuvant,50µL each,also called the meibomian gland dysfunction(MGD)*** the second model,DE conditions were created by the resection of nictitating membranes(NM),Harderian glands(HG),and main lacrimal glands(LG),also called the LGR *** third model involved the topical administration of benzalkonium chloride(BAK)0.1%*** Schirmer test,ocular surface staining with fluorescein,and tear breakup time tests were implemented before and after *** euthanasia,the ocular tissues were ***,conjunctiva,and meibomian glands were treated with periodic acid–Schiff(PAS)staining and haematoxylin–eosin ***:The MGD model triggered inflammation of meibomian *** detected changes in the lipid layer of the tear *** bilateral resection of NM,HG,and LG reduced the watering layer of the tear *** topical administration of BAK of 0.1%solution impacted the mucosal layer of the tear ***:Different changes are observed with different DE syndrome *** composition of the tear film differ depending on which part of the eye is *** studies need to be done to confirm whether an increased thickness of the cornea has any impact on the DE disease.

关键词： ocular surface lid inflammation keratitis tear deficiency rabbits dry eye disease

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Transgenic dry eye mouse models: powerful tools to study dry eye disease

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 635-645页

作者： Dan-Yi Qin Li-Xiang Wang Ying-Ping Deng Department of Ophthalmology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

dry eye disease(DED) is one of the most common chronic multifactorial ocular surface diseases with high prevalence and complex pathogenesis. DED results in several ocular discomforts, vision fluctuation, and even potential damage of the ocular surface, bringing heavy burdens both on individuals and the society. The pathology of DED consists of tear film hyperosmolarity and immune responses on the ocular surface. Mice are widely used for developing models that simulate human DED features for investigating its pathogenesis and treatment. DED can be classified into aqueous-deficiency dry eye(ADDE) and evaporative dry eye(EDE). ADDE can be further divided into Sj?gren syndrome dry eye(SSDE) and non-Sj?gren syndrome dry eye(NSSDE). SSDE mouse models include natural strains, typified by non-obese diabetic(NOD) mice, and genetically engineered ones, like Aire-/-and Id3 knockout mice. Intrinsic EDE mainly refers to meibomian gland dysfunction(MGD). Eda-/-Tabby, Sod1-/-, Elovl1-/-are the most common transgenic MGD mouse models. Transgenic mouse models provide useful tools for studying the pathogenesis of DED and evaluating its novel therapies. This review compares the major transgenic dry eye mouse models and discusses their applications in DED research.

关键词： dry eye disease transgenic mouse models ocular surface pathology

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Role of lymphotoxin alpha as a new molecular biomarker in revolutionizing tear diagnostic testing for dry eye disease

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1883-1889页

作者： Chao-Ran Li Tianjin Medical University eye Hospital Tianjin 310011China

dry eye disease(DED),primarily classified as multifactorial ocular surface disorder,afflicts tens of millions of individuals worldwide,adversely impacting their quality of *** research has been conducted on tear film analysis over the past decades,offering a range of tests to evaluate its volume,health,and ***,early diagnosis and effective treatment for DED continue to pose significant challenges in clinical ***,by recognizing key phenomena in DED such as ocular surface inflammation,hyperosmolarity,and tear film instability,this article provides a comprehensive overview of both traditional and recently developed methods for diagnosing and monitoring *** information serves as a valuable resource not only for clinical diagnosis but also for further research into DED.

关键词： dry eye disease tear film biomarker matrix metalloproteinase 9 lymphotoxin alpha

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