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Silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes with an enhanced antibacterial activity for killing drug-resistant bacteria

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Nano Research 2020年第2期13卷 389-400页

作者： Yu Zhu Jia Xu Yanmao Wang Cang Chen Hongchen Gu Yimin Chai Yao Wang Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

The mounting threat of antibiotic-resistant bacterial infections has made it imperative to develop innovative antibacterial *** we propose a novel antibacterial nanoplatform of silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes constructed via a N-[3-(trimethoxysiltyl)propyl]ethylene diamine(TSD)-mediated method(SWCNTs@mSiO2-TSD@Ag).In this system,the outer mesoporous silica shells are able to improve the dispersibility of SWCNTs,which will increase their contact area with bacteria cell ***,the large number of mesopores in silica layers act as microreactors for in situ synthesis of Ag NPs with controlled small size and uniform distribution,which induces an enhanced antibacterial *** with TSD modified mesoporous silica coated single-walled carbon nanotubes(SWCNTs@mSiO2-TSD)and commercialAg NPs,this combination nanosystem of SWCNTs@mSiO2-TSD@Ag exhibits much stronger antibacterial performance against multi-drug-resistant bacteria Escherichia coli(***)and Staphylococcus aureus(***)in vitro through damaging the bacterial cell membranes and a fast release of silver ***,the in vivo rat skin infection model verifies that SWCNTS@mSiO2-TSD@Ag have remarkably improved abilities of bacterial clearance,wound healing promoting as well as outstanding ***,this novel nanoplatform indicates promising potentials as a safe and powerful tool for the treatment of clinical drug-resistant infections.

关键词： silver nanoparticles single-walled carbon nanotubes drug-resistant bacteria enhanced antibacterial activity wound infections

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An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of drug-resistant bacteria

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CCS Chemistry 2022年第1期4卷 272-285页

作者： Ke Xue Cuihong Yang Chun Wang Yang Liu Jianfeng Liu Linqi Shi Chunlei Zhu Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical BiologyInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071 Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192

This study reports the fabrication of a novel photothermal material formed via the physical blending of excess lauric acid(LA)and cupric acetate,followed by efficient ligand ***,the copper–LA complex exhibited a 12-fold enhancement of the molar extinction coefficient in the nearinfrared(NIR)region relative to aqueous cupric *** by this interesting finding,we formulated these photothermal materials into colloidally dispersed nanoparticles via a technique that combined nanoprecipitation and in situ surface polymerization for antibacterial *** resultant nanoparticles exhibited rapid and stable photothermal responses to NIR irradiation,with a 4-fold enhanced photothermal conversion efficiency relative to aqueous cupric *** a positively charged monomer was incorporated during in situ surface polymerization,these positively charged nanoparticles were ingested efficiently and subsequently digested by drug-resistant *** combining the LA-mediated membrane-damaging effect,copper-mediated Fenton-like reaction,as well as the photothermal effect of the copper–LA complex,a broad-spectrum,multimodal,and synergistic antibacterial effect was achieved both in vitro and in vivo,with the killing efficiency up to 99.99%for ampicillin-resistant Escherichia coli(Ampr ***)and 99.9999%for methicillinresistant Staphylococcus aureus(MRSA).Our newly developed nanobiocide represents a class of exceptional broad-spectrum antibacterial materials,holding great potential for treating drug-resistant infections in clinical settings.

关键词： nanobiocides photothermal materials in situ surface polymerization drug-resistant bacteria multimodal and synergistic therapy

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Flexible electrostatic hydrogels from marine organism for nitric oxide-enhanced photodynamic therapy against multidrug-resistant bacterial infection

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Science China Materials 2022年第10期65卷 2850-2860页

作者： Yujie Sun Rong-Lai Wen Dan Yu Yiwen Zhu Liang Zheng Xiangdong Liu Haoran Wang Bingran Yu Fu-Jian Xu State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical TechnologyMinistry of Education)and Laboratory of Biomedical MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityXiasha Higher Education ZoneHangzhou 310018China

The abuse of antibiotics in treating microbial infections has led to the emergence and prevalence of drugresistant ***,the development of novel antibacterial materials is attracting increasing ***,a series of flexible electrostatic hydrogels with excellent antibacterial ability were constructed using a mixture of nitric oxide(NO)-releasing nitrated chitosan(CSNO)and mesotetra(4-carboxyphenyl)porphine(TCPP)with salmon sperm DNA(ssDNA)*** cultured with gram-negative bacteria under solar simulator irradiation,TCPP-CSNO_(m)ssDNA_(n) hydrogels released reactive oxygen species(ROS)and NO to produce peroxynitrite ions(ONOO^(−)).ONOO−is efficient at killing bacteria,thereby improving the antimicrobial ability of photodynamic therapy against gram-negative *** hydrogels exhibited powerful antibacterial activity in vivo when used to treat skin infections caused by drugresistant bacteria,making them a promising candidate for clinical applications.A string of antibacterial hydrogels that release ROS and NO synergistically can bring new possibilities for effectively killing drug-resistant bacteria and be of great value in anti-infection wound dressings and other applications.

关键词： electrostatic hydrogel drug-resistant bacteria peroxynitrite photodynamic therapy

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Medical titanium surface-modified coatings with antibacterial and anti-adhesive properties for the prevention of implant-associated infections

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Journal of Materials Science & Technology 2024年第12期179卷 208-223页

作者： Dongliang Huo Fengqian Wang Fengjuan Yang Tongyao Lin Qing Zhong Sui-Ping Deng Jingxian Zhang Shaozao Tan Langhuan Huang Guangdong Engineering&Technology Research Centre of Graphene-like Materials and Products Department of ChemistryCollege of Chemistry and Materials ScienceJinan UniversityGuangzhou 510632China

Implant-associated infections(IAIs)caused by drug-resistant bacteria remain a critical factor in the fail-ure of implant ***,it is urgent to develop an effective anti-infection coating for im-plant surface modification to prevent ***,an antibacterial and anti-adhesive coating(CMP-Ti)constructed on the surface of titanium implants is reported,formed by the nanomaterial CeO_(2)@Mn_(3)O_(4) NRs(CM NRs)with antibacterial activity and the superhydrophilic polymer polyethylene glycol(PEG).The nanocatalyst CM NRs on the surface of CMP-Ti induce ferroptosis-like death of bacteria by catalyzing the production of hydroxyl radical(·OH)and singlet oxygen(^(1)O_(2))and the consumption of glutathione(GSH).The superhydrophilic coating of CMP-Ti can effectively prevent adherence of drug-resistant bac-teria and avoid biofilm *** combining the"active offense"antibacterial mechanism with the"passive defense"anti-adhesion mechanism,CMP-Ti can kill bacteria and inhibit biofilm *** results of in vivo studies showed that CMP-Ti effectively prevented implant-associated infections caused by Methicillin-resistant Staphylococcus aureus(MRSA),thus promoting tissue repair and ***,this multifunctional coating combining"active offense"and"passive defense"provides a promising way to prevent IAIs caused by drug-resistant bacteria and to promote tissue repair in the future.

关键词： Medical titanium Antibacterial coatings drug-resistant bacteria Biofilm inhibition Ferroptosis-like death

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Molecular docking-aided AIEgen design: concept, synthesis and applications

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Science China Chemistry 2024年第8期67卷 2614-2628页

作者： Jian-Qing Zhang Xiao-Yu Xu Fu-Sheng Liu Shu-Qiang Cao Yu-Xin Gui Yi-Wen Su Xiao-Yu He Ji-Yuan Liang You-Quan Zou Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Key Laboratory of Combinatorial Biosynthesis and drug Discovery Ministry of EducationWuhan UniversityWuhan 430071China Tai Kang Center for Life and Medical Sciences Wuhan UniversityWuhan 430071China Department of Hepatobiliary Pancreatic SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China

Aggregate-induced emission luminogens(AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable research interests during the last few years. Herein, molecular docking-aided AIEgen design has been reasonably proposed and AIEgen TBQZY with excellent ~1O_(2) generation ability has been synthesized. The newly developed TBQZY could efficiently kill S. epidermidis and methicillinresistant S. epidermidis(MRSE) by tightly binding to bacteria and triggering the accumulation of ~1O_(2) in bacteria. TBQZY specifically regulated the immune system and polarized macrophages from M1 to M2 to accelerate the elimination of biofilm in vivo. In addition, healing acceleration was observed in chronic wounds treated with TBQZY, and side effects were ***, TBQZY had extraordinary potential for combating drug-resistant bacteria in the clinical setting. This research not only provided new concepts for the design of AIEgens, but also shed some lights on the discovery of drugs against drug-resistant bacteria.

关键词： AIEgen molecular docking drug-resistant bacteria biofilm chronic wounds healing

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In Vitro and In Vivo Antibacterial Activity of Patchouli Alcohol from Pogostemon cablin

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Chinese Journal of Integrative Medicine 2021年第2期27卷 125-130页

作者： WAN Feng PENG Fu XIONG Liang CHEN Jian-ping PENG Cheng DAI Min School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu(610075)China State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine ResourcesSichuan Province and Ministry of Science and TechnologyChengdu(610075)China School of Chinese Medicine the University of Hong KongHong Kong SARChina School of Medical Laboratory Science Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate the antibacterial activity of patchouli alcohol(PA)against 127 bacteria strains,including the common bacteria and drug-resistant bacteria strains both in the in vitro and in vivo ***:For the in vitro trial,the antibacterial property of PA against 107 Gram-positive and 20 Gram-negative bacteria strains was screened by agar double dilution *** the in vivo trial,specific pathogen free Kunming strain of both male and female white mice,were used to test the protective ability of PA after being injected with the median lethal dose of the tested ***:PA possessed antibacterial activity against all the tested 127 *** the in vitro test,PA could inhibit both Gram-negative bacteria(25-768μg/m L)and Gram-positive bacteria(1.5-200μg/m L).Particularly,PA was active against some drug-resistant bacteria like methicillin-resistant Staphylococcus aureus(MRSA).PA also exhibited in vivo anti-MRSA activity in mice via intraperitoneal *** could protect mice entirely infected with MRSA at 100 and 200 mg/kg,while 80% mice injected with MRSA could be protected at a low dose of 50 mg/***:PA might be a potential antibacterial drug from natural sources and might be worthy to explore its mechanism and application in further study.

关键词： patchouli alcohol antibacterial activity drug-resistant bacteria in vivo in vitro

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Chloromycetin resistance of clinically isolated E coli is conversed by using EGS technique to repress the Chloromycetin acetyl transferase

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World Journal of Gastroenterology 2005年第46期11卷 7368-7373页

作者： Mei-Ying Gao Chuan-Rui Xu RU Chen Shou-Gui Liu Jiang-Nan Feng Department of Infectious Diseases Tongji Hospital Tongji JVledical CollegeHuazhong University of Science and Technology Wuhan 430030Hubei Province China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030Hubei Province China Laboratory of Immunology Wuhan Bioproduct Institute of Ministry of Public Health Wuhan 430060 Hubei Province China

AIM： To explore the possibility of repression of chloromycetin （Cm） acyl transferase by using external guided sequence （EGS） in order to converse the clinical E coli isolates from Cm- resistant to Cm- sensitive. METHODS： EGS directed against chloromycetin acetyl transferase gene （cat） was cloned to vector pEGFP-C1 which contains the kanamycin （Kin） resistance gene. The recombinant plasmid pEGFP-C1＋EGScatl＋cat2 was constructed and the blank vector without EGS fragment was used as control plasmids. By using the CaCl2 transformation method, the recombinant plasmids were introduced into the clinically isolated Cm resistant but Km sensitive E coli strains. Transformants were screened on LB agar plates containing Kin. Extraction of plasmids and PCR were applied to identify the positive clones. The growth curve of EGS transformed bacteria cultured in broth with Cm resistance was determined by using spectrophotometer at A600. drug sensitivity was tested in solid culture containing Cm by using KB method. RESULTS： Transformation studies were carried out on 16 clinically isolated Cm-resistant （250 μg/mL of Cm） E colistrains by using pEGFP-C1-EGScatlcat2 recombinant plasmid. Transformants were screened on LB-agar plates containing Km after the transformation using EGS. Of the 16 tested strains, 4 strains were transformed successfully. Transformants with EGS plasmid showed growth inhibition when grown in liquid broth culture containing 200 μg/mL of Cm. In drug sensitivity test, these strains were sensitive to Cm on LB-agar plates containing 200 μg/mL of Cm. Extraction of plasmids and PCR amplification showed the existence of EGS plasmids in these four transformed strains. These results indicated that the Cat of the four clinical isolates had been suppressed and the four strains were converted to Cm sensitive ones. CONCLUSION： The EGS directed against Cat is able to inhibit the expression of Cat, and hence convert Cm- resistant bacteria to Cm-sensitive ones. Thus, the EGS h

关键词： External guide sequence drug-resistant bacteria Conversion of drug resistance

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Design and synthesis of a series of quinazolinone derivatives as antibiotic against ***

Design and synthesis of a series of quinazolinone derivative...

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第十届全国化学生物学学术会议

作者： Jianbin Zhen Kewu Yang Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials ScienceNorthwest University

drug-resistant bacteria pose an urgent public-health crisis. Over the years, β-lactams were the antibiotics of choice for treatment of S. aureus infections1. However, the overuse of these antibiotics has resulted in a large number of bacteria with resistance to most current drugs. So, the present needs for new classes of antibacterial drugs are essential. Quinazolinone represents a class of annulated six-membered nitrogen heterocycles2-3. These compounds show extensively biological and pharmacological activity, for instance, antitumor, anti-inflammatory, antihistamine, and antimicrobial et al. Based on the above information, we designed and synthesized quinazolinone derivatives as new antibiotics with potent activity against S. aureus. The synthesis route was showed in Scheme 1.

关键词： drug-resistant bacteria Antibiotics Quinazolinone

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