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Photocaged prodrug under NIR light-triggering with dual-channel fluorescence: in vivo real-time tracking for precise drug delivery

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Science China Chemistry 2018年第10期61卷 1293-1300页

作者： Zhiqian Guo Yaguang Ma Yajing Liu Chenxu Yan Ping Shi He Tian Wei-Hong Zhu Key Laboratory for Advanced Materials and Institute of Fine Chemicals Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering East China University of Science and Technology

Light-triggered drug delivery system is an effective strategy for precise diagnosis and therapy in cancer treatment. However, it suffers from difficultly balancing the dosimetry of drug with light dose and a lack of in vivo models for validating their clinical benefits. Here we report an unprecedented near-infrared(NIR) light photocaged cyanine-based prodrug Cy-CPT-Biotin with dual-channel fluorescence mode, enabling NIR light to precisely regulate where, when and how the intact and active prodrugs are delivered. The synergy of photochemical reaction and modulation in π-conjugated polyene backbone of cyanine can fully perform distinct dual-channel fluorescence changes in a NIR light-mediated manner. The prodrug has striking characteristics of excellent tumor-targeting ability, real-time monitoring of the in vivo behaviors by dual-channel mode and NIR-light triggering,especially for achieving fine regulation and on-demand drug release in the precise dosimetry of drug with light dose in living animals. This optical orthogonality strategy that conjuncts with NIR light-triggered and dual-channel fluorescence in vivo imaging provides a powerful tool for in vivo real-time tracking and finely tuning the prodrug release for precise drug delivery.

关键词： near-infrared cyaninc dye dual-channel fluorescence drug-release photocage tumor targeting

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Local drug Delivery Strategy for Cancer Treatment: Use of Biocompatible Sol-Gel-Derived Porous Materials

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New Journal of Glass and Ceramics 2013年第2期3卷 74-79页

作者： Odile Cristini-Robbe Florian Ruyffelaere Florent Dubart Ange Uwimanimpaye Christophe Kinowski Remy Bernard Catherine Robbe-Masselot Ikram El Yazidi Sylvia Turrell LASIR (UMR 8516) Université Lille1 Villeneuve d’Ascq France PhLAM (UMR 8523) Université Lille1 Villeneuve d’Ascq France Unité Glycobiologie (UMR 8576) Université Lille1 Villeneuve d’Ascq France

Porous silica xerogel materials have been developed to use as drug-release agents to be implanted directly in or near cancerous tissues. In order to test the capacity of the materials to absorb and then to release medicinal substances, a battery of examinations (UV and visible micro-Raman, porosity measurements, UV-visible absorption spectra) have been made using test drug molecules (clotrimazole, primaquine diphosphate and the anti-cancer agent vinblastine sulphate). Results show that the molecules can be post-doped into the gels and the Raman data provide indications of the best conditions for detecting the substances absorbed in the gels. Spectroscopic results show that the drug molecules are released by the xerogel over a period of 10 days. These results are promising for the development of these materials as drug-release agents.

关键词： Sol-Gel Micro-Raman Post-Doping Chemotherapy Silica Gels drug-release Agents

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