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S-1 induced hepatic steatosis in patients with pancreatic cancer:Retrospective analysis

World Journal of Gastrointestinal Oncology 2017年第8期9卷 314-318页

作者： Kunihiro Tsuji Hisashi Doyama Department of Gastroenterology Ishikawa Prefectural Central HospitalIshikawa 920-8530Japan

To determine whether S-1 induces hepatic steatosis in patients being treated for pancreatic cancer. METHODSThis retrospective study evaluated 22 patients who received oral S-1 as a first-line treatment for pancreatic cancer between January 2008 and July 2015 at the Ishikawa Prefectural Central Hospital. Patients underwent abdominal computed tomography (CT) scans before chemotherapy and within 3 mo from the start of treatment. CT numbers of the liver and spleen were measured before and after S-1 administration. Steatosis was diagnosed when the ratio of the CT number of the liver to that of the spleen (liver/spleen ratio) was 2 (range, 18-27 kg/m2). Of the 22 patients, six (27%) regularly consumed alcohol, and five (23%) had liver metastases. The mean ratio of CT number of the liver to the spleen was significantly higher before administration of S-1 (1.27 vs 1.09, P = 0.012) compared with after. Of the 22 patients, five (23%) had hepatic steatosis and 17 (77%) did not. The pretreatment demographic and clinical characteristics of these two groups showed no significant differences. The relationship between liver/spleen ratio and alanine transaminase activity in these patients. A statistically significant inverse correlation was observed (r = -0.417, P induced hepatic steatosis. Care should be taken during S-1 treatment of patients with pancreatic cancer.

关键词： S-1 Hepatic steatosis Pancreatic cancer drug induced hepatitis 5-fluorouracil

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