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transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma

World Journal of Radiology 2017年第5期9卷 245-252页

作者： Giorgio Greco Tommaso Cascella Antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani Giuseppina Calareso Francesca G Greco Antonio Ragnanese Marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico Department of Radiology Interventional RadiologyNuclear Medicine and RadiotherapyNational Cancer Institute Gastroenterology Unit Ospedali Riuniti FoggiaUniversity of Foggia Radiology and Interv-entional Radiology Unit Hepato-biliary Surgery and Liver Transplantation Unit National Cancer Institute

AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative *** drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with *** to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance *** out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted *** DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d *** objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST *** examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of *** overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis.

关键词： Embozene tandem drug eluting beads drug eluting bead transarterial chemoembolization transarterial chemoembolization Hepatocellular carcinoma

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