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Effects of Da Ding Feng Zhu Decoction in 30 Cases of Liver Fibrosis

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Journal of Traditional Chinese Medicine 2003年第4期23卷 251-254页

作者：李伟林王才党张君利王薇 Taizhou Municipal Hospital of Traditional Chinese Medicine Zhejiang Province 318000

To study the clinical effects of Da Ding Feng Zhu (大定风珠) Decoction on liver fibrosis. 56 patients withliver fibrosis due to chronic hepatitis B were randomly divided into a treatment group (30 cases treatedwith Da Ding Feng Zhu Decoction) and a control group (26 cases treated with colchicine). The serumlevels of hyaluronic acid (HA), procollagen Ⅲ (PC-Ⅲ), Ⅳ collagen (Ⅳ-C) and Laminin (LN) of thepatients were determined, compared and analyzed before treatment and after 3-month treatment in the twogroups. The results showed that in the treatment group, the levels of HA, PC-Ⅲ, Ⅳ-C and LN after3-month treatment were significantly lowered as compared to that before treatment (P＜0.01). In thecontrol group, only the HA level was obviously lowered (P＜0.05). There was an significant difference(P＜0.05) in PC-Ⅲ and Ⅳ-C and a very significant difference (P＜0.01) in HA after treatment between thetwo groups. It is therefore concluded that Da Ding Feng Zhu Decoction can lower serum indexes of liverfibrosis.

关键词： Phytotherapy Adult Collagen Type III Collagen Type IV drug combinations drugs, Chinese Herbal Female Hepatitis B Humans Hyaluronic Acid Laminin Liver Cirrhosis Male Middle Aged

Clinical Observation in 86 Cases of Acne Vulgaris Treated with Compound Oldenlandis Mixture

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Journal of Traditional Chinese Medicine 2003年第4期23卷 255-256页

作者：刘瓦利沈冬宋坪许铣周永生 Dermatology Department of Guang'anmen Hospital China Academy of Traditional Chinese Medicine Beijing 100053

86 cases of acne vulgaris were treated with Fu Fang She She Cao He Ji (复方蛇舌草合剂Compound Oldenlandis Mixture), with the other 34 cases treated with Dang Gui Ku Shen Wan (当归苦参丸Pills Prepared from Chinese Angelica and Flavescent Sophora Root) as the controls, to observe the therapeutic effect of the former. The results showed that the cure plus markedly effective rate was 73.26% in the treatment group, and 47.06% in the control group, with a significant difference in the cure plus markedly effective rate between the two groups (P<0.01), and also in the total effective rate between the two groups significant (P<0.05). It may be concluded that the Compound Oldenlandis Mixture is a better agent for the illness.

关键词： Oldenlandia Phytotherapy Acne Vulgaris Adolescent Adult drug combinations drugs, Chinese Herbal Female Humans Male

Treatment of 482 Cases of Cervical Spondylopathy by Combining Point-injection and Needle-warming via Moxibustion

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Journal of Traditional Chinese Medicine 2001年第1期21卷 31-33页

作者：王光月屈凤林陈海英 TCM Hospital of Fangshan District Beijing 102400

From January 1993 to December 1996, we treated 482 cases of cervical spondylopathy with a combined method of point-injection and needle-warming via moxibustion. Except for the cases of sympathetic nerve type and spinal cord type, the combined method was superior to traction therapy in the control group and reported as follows.Clinical DataThe Criteria of Diagnosis and Curative Effect in TCM issued by the State Administrative Bureau of TCM and Pharmacy in 1994 was adopted for the enrollment of patients of cervical spondylopathy and the pathological typing. Only the patients who had completed the treatment and with complete records were collected for analysis.

关键词： Acupuncture Points Acupuncture Therapy Cervical Vertebrae Moxibustion Plant Extracts Adult Aged drug combinations drugs, Chinese Herbal Female Humans Injections Male Middle Aged Phenanthrolines Spinal Osteophytosis Vitamin B 12

Twenty-eight Cases of Neuritis of Lateral Cutaneous Nerve of Thigh Treated by Acupuncture and Point-Injection

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Journal of Traditional Chinese Medicine 2001年第1期21卷 29-30页

作者：廖明扬周永生 The First Affiliated Hospital Guiyang College of Traditional Chinese Medicine Guiyang 550001Guizhou Province

Neuritis of lateral cutaneous nerve of thigh, also called meralgia paresthetica, is a commonly encountered disease in clinical practice. The author has treated 28 cases of meralgia paresthetica since 1996 by acupuncture plus point-injection with satisfactory results. A report follows.Clinical Data Among the 28 cases, 13 were male and 15 female. Their age ranged from 24 to 72 years, most of the patients being 35 to 50 years; the duration of illness varied from one month to ten years and 6 cases were affected on left side, 8 cases on right side and 14 cases on both sides.

关键词： Acupuncture Points Acupuncture Therapy Plant Extracts Adult Aged Animals drug combinations drugs, Chinese Herbal Female Humans Injections Male Middle Aged Neuritis Phenanthrolines Thigh Vitamin B 12

A review of artificial intelligence applications for antimicrobial resistance

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Biosafety and Health 2021年第1期3卷 22-31页

作者： Ji Lv Senyi Deng Le Zhang College of computer science Sichuan UniversityChengdu 610065China Thoracic Surgery Research Laboratory Department of Thoracic SurgeryWest China HospitalSichuan Universitychengdu 610065China Medical Big Data Center of Sichuan University Chengdu 610065China PERA Corporation Ltd. Beijing 100025China

The wide use and abuse of antibiotics could make antimicrobial resistance(AMR)an increasingly serious issue that threatens global health and imposes an enormous burden on society and the *** avoid the crisis of AMR,we have to fundamentally change our *** intelligence(AI)represents a new paradigm to combat ***,various AI approaches to this problem have sprung up,some of which may be considered successful cases of domain-specific AI applications in ***,to the best of our knowledge,there is no systematic review illustrating the use of these AI-based applications for ***,this review briefly introduces how to employ AI technology against AMR by using the predictive AMR model,the rational use of antibiotics,antimicrobial peptides(AMPs)and antibiotic combinations,as well as future research directions.

关键词： Artificial intelligence Antimicrobial resistance Whole-genome sequencing Clinical decision support systems drug combinations

Complex diseases demand novel treatment strategies: understanding drug combination

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drug Combination Therapy 2022年第2期4卷 5-16页

作者： Renata Siqueira de Mello Vanessa Fernandes Arnaud-Sampaio Lucas Ferreira Maciel Vanessa de Sá Talita Glaser Henning Ulrich Claudiana Lameu Departamento de Bioquímica Instituto de QuímicaUniversidade de São PauloSPBrazil

For many multigene or multifactorial diseases,the one-drug therapy for inhibiting a defined molecular target is often less effective than combined ***,drug combination therapies are multitargeted,so the mechanisms or even interactions are often *** drug-drug interactions may promote alteration of pharmacokinetic or pharmacodynamic activities of one drug by another *** interactions may change the expected effect of medications through polymorphisms that alter the expression or activity of the drug-mediated enzyme and the cell signaling cascade,such as drug-gene interactions and drug-drug-gene *** number of possible existing interactions requires appropriate methods of *** this review,we summarized combination therapies for cancer,as well as for viral,cardiovascular,and neurological ***,we also highlight known methodologies,such as in vitro methods based on Loewe’s and Bliss’s pioneer models and in silico methods based on online available *** more elaborate methods and reliable results,multitarget therapies through drug combinations may increasingly benefit patients suffering from complex diseases.

关键词： drug combinations multitarget therapy combination therapy drug-drug interaction in vitro in silico methods and models

Jiedu Tongbi Tang Plus Phenytoin Sodium for Severe Acute Sciatica

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Journal of Traditional Chinese Medicine 2003年第4期23卷 260-260页

作者：王德昌段树民王薇 ChinesePeople‘sPublicSecurityUniversityHospital Beijing100038 不详

Case 1: Mr. Li, a 55-year farmer from Hebeiprovince, paid his first visit on August 11, 1995. Thepatient complained of a sudden pain in the area fromhis left buttock down to the posterolateral aspect ofthe leg.

关键词： Phytotherapy Acute Disease drug combinations drugs, Chinese Herbal Follow-Up Studies Humans Male Middle Aged Phenytoin Sciatica