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Approved natural products-derived nanomedicines for disease treatment

Chinese Journal of Natural Medicines 2024年第12期22卷 1100-1116页

作者： LI Xiaotong LAI Yaoyao WAN Guanghan ZOU Jiahui HE Wei YANG Pei School of Pharmacy China Pharmaceutical University School of Science China Pharmaceutical University

In recent years, there has been an increasing emphasis on exploring innovative drug delivery approaches due to the limitations of conventional therapeutic strategies, such as inadequate drug targeting, insufficient therapeutic efficacy, and significant adverse effects. Nanomedicines have emerged as a promising solution with notable advantages, including extended drug circulation, targeted delivery, and improved bioavailability, potentially enhancing the clinical treatment of various diseases. Natural products/materials-derived nanomedicines, characterized by their natural therapeutic efficacy, superior biocompatibility, and safety profile, play a crucial role in nanomedicine-based treatments. This review provides a comprehensive overview of currently approved natural productsderived nanomedicines, emphasizing the essential properties of natural products-derived drug carriers, their applications in clinical diagnosis and treatment, and the current therapeutic potential and challenges. The aim is to offer guidance for the application and further development of these innovative therapeutic approaches.

关键词： Diagnosis Disease treatment drug carriers Nanomedicine Natural properties Safety

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Advances in studies of phospholipids as carriers in skin topical application

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Journal of Nanjing Medical University 2007年第6期21卷 349-353页

作者： Juanjuan Liu Gan Hu Department of Dermatology the Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China

Objective： This article provides an overview of characteristics of phospholipids, the characteristics and influential factors of liposome and microemulsion as carriers for skin delivery of drugs, and the latest advances of the phospholipids carriers in transdermal delivery systems. The perspective is that phospholipids carriers may be capable of a wide range of applications in the transdermal delivery system.

关键词： phospholipids liposome phospholipids microemulsion skin topical application drug carriers

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Experimental study on a bioabsorbable super-high molecular weight polyD,L-Lactic acid plate containing recombined human bone morphogenetic protein-2 for fracture healing

Experimental study on a bioabsorbable super-high molecular w...

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2007年上海市医用生物材料研讨会

作者： WANG Jinwu CHOU Ningfeng RUI Biyu GUO Shangchun TAN Ruizhen ZHAO Binghui FAN Cunyi NI Weifeng Zeng bingfang LI Xuesong Department of Orthopaedics The Sixth Municipal People’s Hospital Shanghai Jiao Tong University Shanghai 200233 China

＜正＞To investigate the effect of a bioabsorbable super- high molecular weight polyD,L-Lactic acid （PDLLA） plate containing sustainingly released recombined human bone morphogenetic protein-2（rh BMP-2） on fracture internal fixation and healing through activity experiment in vivo.32 New Zealand rabbits （male or female） were used in the study.A 2.5 mm middle ulna osteotomy was made *** right side was experiment side,fixed internally by PDLLA containing rhBMP-2,and the left control side,fixed by common *** rabbits were randomly divided into 4 *** a follow-up of 2,4,8 and 12 weeks,the ulnas were examined visually,radiographically, histologically,and by computer graph analysis to compare the fracture healing,fixation results and degradation processes at different times after being fixed by the two types of plates.2,4,8 and 12 weeks after operation,visual analysis and examination of radiograph demonstrates that ulna fractures were fixed stably with those two bioactive *** movement was observed,and good reduction was *** examination shows that 8 weeks after operation 7 rabbits had a good osteotomy healing on the experiment side,2 rabbits had less callus on the control side,and other rabbits only had fibro-connective tissue filling at the osteotomy sites.12 weeks after operation, 8 rabbits had good healing at the osteotomy on both experimental and controlling side,but the experiment side showed better compatibility between plates and surrounding tissue,faster bone formation,more bone regeneration mass and better medullary canal *** graph analysis indicated that at the same period the osteotomy on the experiment side produced better and more trabeculae（p＜0.01）.Bioabsorbable super-high molecular weight poly D,L-Lactic acid （PPLLA） plate containing recombined human bone morphogenetic protein-2（rhBMP-2） has good biocompatibility,osteoinducive activity to enhance fracture healing,no interference with radiographica

关键词： Bone morphogenetic protein PolyD,L-lactic acid Fracture fixation drug carriers

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MoS2@PEG Nanocomposites Promoted Locomotor Recovery via Inducing Anti-inflammatory Macrophage Polarization after Spinal Cord Injury

MoS2@PEG Nanocomposites Promoted Locomotor Recovery via Indu...

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第十二届全国免疫学学术大会

作者： Sun Guodong Yang Shuxian The First Affiliated Hospital Jinan University Biomedical Translational Research Institute Jinan University

Spinal cord injury(SCI) can lead to permanent motor and sensory deficits.A pharmacological approach effectively modulating macrophage polarization is promising for the recovery,which is unfortunately prohibited by the deleterious side effects associated with the high ***,well-defined MoS@PEG(PEG = poly(ethylene glycol)) nanoflowers were introduced as the effective carriers for the locomotor recovery after *** etanercept(ET)-loading MoS@PEG significantly inhibited the expression of M1-related pro-inflammatory cytokines(TNF-α,CD86 and iNOS),while promoted M2-related anti-inflammatory cytokine(Agr1,CD206 and IL-10) *** showed that long-circulating MoS@PEG nanocarriers could effectively extravasate into the injured spinal cord up to 96 hours after *** the clinically relevant contusion injury model in mice,the ET-MoS@PEG induced macrophage polarization was accompanied by increased presence of anti-inflammatory M2 *** further histopathology studies showed that ET-MoS@PEG treatment led to improve locomotor recovery,reduced injured area at the central lesion site,and protected survival motor *** results suggest that ET-MoS@PEG nanodrugs could be applied to inhibit inflammatory events and potentiate macrophage-modulating injured cord immunotherapies.

关键词： molybdenum disulfide(MoS2) drug carriers spinal cord injury(SCI) inflammation locomotor recove

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可降解的聚合物纳米凝胶的制备及载药研究

可降解的聚合物纳米凝胶的制备及载药研究

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2014年全国高分子材料科学与工程研讨会

作者：杨武利王杨边珊珊田野菲复旦大学高分子科学系聚合物分子工程国家重点实验室

聚合物纳米粒子载药系统由于具有良好的生物相容性、较长的循环时间,较高的药物稳定性,表面丰富的基团易链接靶向分子,以及纳米粒子本身具有的对肿瘤组织的增强渗透与保留效应(EPR)等特点,在治疗肿瘤方面具有广阔的应用前景。环境响应... 详细信息

聚合物纳米粒子载药系统由于具有良好的生物相容性、较长的循环时间,较高的药物稳定性,表面丰富的基团易链接靶向分子,以及纳米粒子本身具有的对肿瘤组织的增强渗透与保留效应(EPR)等特点,在治疗肿瘤方面具有广阔的应用前景。环境响应性纳米粒子由于对外界特定的刺激(如温度、pH、氧化还原、光、磁场、电场、超声等)可以产生响应,随之发生

关键词： Nanoparticle biodegradable redox-responsive drug carriers

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