检索结果-南通市图书馆

Recognition of self and altered self by T cells in autoimmunity and allergy

Protein & Cell 2013年第1期4卷 8-16页

作者： Lei Yin Shaodong Dai Gina Clayton Wei Gao Yang Wang John Kappler Philippa Marrack Howard Hughes Medical Institute and Integrated Department of Immunology National Jewish HealthDenverCO 80206USA Integrated Department of Immunology National Jewish HealthDenverCO80206USA Program in Structural Biology and Biophysics University of Colorado DenverSchool of MedicineAuroraCO 80045USA Department of Biochemistry and Molecular Genetics University of Colorado DenverSchool of MedicineAuroraCO 80045USA

T cell recognition of foreign peptide antigen and toler-ance to self peptides is key to the proper function of the immune ***,in the thymus T cells that rec-ognize self MHC+self peptides are deleted and those with the potential to recognize self MHC+foreign pep-tides are selected to *** there are excep-tions to these *** and allergy are two of the most common immune diseases that can be related to recognition of *** genes work together to lead to *** those,particular MHC alleles are the most strongly associated,reflecting the key importance of MHC presentation of self peptides in autoimmunity.T cells specific for combinations of self MHC and self pep-tides may escape thymus deletion,and thus be able to drive autoimmunity,for several reasons:the relevant self peptide may be presented at low abundance in the thy-mus but at high level in particular peripheral tissues;the relevant self peptide may bind to MHC in an unusual register,not present in the thymus but apparent else-where;finally the relevant self peptide may be post translationally modified in a tissue specific *** some types of allergy,the peptide+MHC combination may also be fully derived from *** the combi-nation in question may be modified by the presence of other ligands,such as small drug molecules or metal *** these types of allergies may act like the post translationally modified peptides involved some types of autoimmunity.

关键词： altered self neoantigen antigen presenting T cell recognition autoimmunity allergy diabetes der-matitis drug hypersensitivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity

引用

World Journal of Gastroenterology 2010年第26期16卷 3339-3342页

作者： Soichi Sano Hiroki Ueno Keiko Yamagami Yosuke Yakushiji Yoshihiro Isaka Isao Kawasaki Masashi Takemura Takeshi Inoue Masayuki Hosoi Department of Internal Medicine Osaka City General Hospital Osaka 534-0021 Japan Department of Metabolism and Endocrinology Osaka City General Hospital Osaka 534-0021 Japan Department of Gastrointestinal Surgery Osaka City General Hospital Osaka 534-0021 Japan Department of Pathology Osaka City General Hospital Osaka 534-0021 Japan

We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based onthese observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly.

关键词： Terbinafi ne drug hypersensitivity Human herpesvirus 6 Cytomegalovirus Intestinal perforation Ileum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Successful interferon desensitization in a patient with chronic hepatitis C infection

引用

World Journal of Gastroenterology 2009年第33期15卷 4196-4198页

作者： Seyed Alireza Taghavi Ahad Eshraghian Gastroentero-hepatology Research Center of Shiraz University of Medical Science Nemazee Hospital

Treatment of hepatitis C, even when absolutely necessary, is almost impossible when interferon cannot be administered for any reason. We report a 65-year-old patient with chronic hepatitis C virus (HCV) infection and fibrosis, who was unable to receive interferon because of systemic hypersensitivity. The patient was desensitized successfully through gradual incremental exposure to interferon, and HCV infection was eradicated after a complete course of treatment, with no further allergic reactions. This case report that describes successful eradication of hepatitis C in a patient with advanced liver disease after desensitization to interferon revealed that desensitization may not necessarily damage the therapeutic efficacy of the drug.

关键词： Chronic hepatitis C Desensitization drug hypersensitivity Interferon a2b Ribavirin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

REACTIVE RETICULOSIS

引用

中华医学杂志(英文版) 1964年第11期83卷 763-771页

作者：黄克维刘海川

*** cases of reactive reticu-losis were *** importantclinical manifestations were irregularfever,enlargement of the liver andspleen,and leukopenia,accompanied byfrequent skin rash and intestinal ulcera-tions,and the main pathologic findingsconsisted of marked hyperplasia of thereticuloendothelial cells in the liver,spleen,lymph nodes and bone marrowwith preservation of the normal archi-tecture of the spleen and lymph *** pathogenesis of reactivereticulosis was discussed,and allergy todrugs was suggested.

关键词： BONE MARROW CLASSIFICATION DIAGNOSIS, DIFFERENTIAL drug hypersensitivity LIVER LYMPH NODES PATHOLOGY RETICULOENDOTHELIOSIS SPLEEN

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Mesalamine hypersensitivity and Kounis syndrome in a pediatric ulcerative colitis patient

引用

World Journal of Gastroenterology 2008年第46期14卷 7141-7142页

作者： Geoge N Kounis Sophia A Kouni George Hahalis Nicholas G Kounis Department of Medical Sciences Patras Highest Institute of Education and Technology

5-aminosalicylic acid （mesalamine） rarely induces hyper- sensitivity reactions. If chest pain associated with atypical electrocardiographic changes are seen during its administration, one should always bear in mind type I variant of Kounis syndrome. This variant includes patients, of any age, with normal coronary arteries, without predisposing factors for coronary artery disease, in whom the acute release of inflammatory mediators from mast cells can induce either sudden coronary artery narrowing, without increase of cardiac enzymes and troponins, or coronary artery spasm that progresses to acute myocardial infarction, with elevated cardiac enzymes and troponins.

关键词： drug hypersensitivity Kounis syndrome Mesalamine Salicylates

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Active Monitoring of Adverse drug Reactions with Neural Network Technology

引用

Chinese Medical Journal 2017年第12期130卷 1498-1501页

作者： Tao Wu Chang-Chun Gao Jing-Sheng Lin Jia-Ling Zha The Glorious Sun School of Business and Management Donghua University Shanghai 200051 China Department of Information Technology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Information Technology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

INTRODUCTIONAn adverse drug reaction （ADR） is unintended injuries caused by the drug at normal doses during normal use. ADR monitoring is a long-term work of medical institutions. Medical institutions at all levels have their corresponding requirements of reporting ADRs.i On December 12, 2010, the National Health and Family Planning Commission of the People＇s Republic of China issued the ＂Administration of adverse drug reaction report and monitoring＂. The aims were to enhance drug postmarketing surveillance, standardize ADR monitoring and reporting, and control drug risks in a timely and effective manner to ensure the safety of patients.

关键词： Artificial Intelligence Deep Learning drug hypersensitivity Neural Networks

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：