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Narrative review-drug delivery in age-related macular degeneration

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Annals of Eye Science 2021年第4期6卷 6-25页

作者： Rachel Israilevich Raziyeh Mahmoudzadeh Mirataollah Salabati David Xu Sidney Kimmel Medical College Thomas Jefferson UniversityPhiladelphiaPAUSA Mid Atlantic Retina Wills Eye HospitalThomas Jefferson UniversityPhiladelphiaPAUSA

This narrative review highlights routes of ocular drug delivery for age-related macular degeneration(AMD).AMD is the leading cause of irreversible blindness in industrialized countries and accounts for 8.7%of blindness *** AMD can be classified into two subtypes:late-stage dry AMD[known as geographic atrophy(GA)]and neovascular AMD(nAMD).GA is often bilateral and results from progressive and irreversible loss of photoreceptors and areas of the retinal pigment *** AMD is characterized by angiogenesis from the choroid to the normally avascular regions underneath the retinal pigment epithelium(RPE)or retina,a process known as choroidal neovascularization(CNV).Various targeted therapeutic options are currently available to reduce the progression rate and maintain vision in patients with *** delivery of anti-VEGF protein treatments to halt CNV is currently the gold-standard of care for *** and suprachoroidal delivery approaches are also being explored for gene and molecular *** in nanotechnology and biomaterials have also led to the development of microscopic drug delivery systems,including hydrogels,microparticles,nanoparticles,implants,and *** therapy and stem cell therapy has recently emerged as a potential candidate treatment modality for AMD and other retinal *** drug targets and modalities have stimulated exciting developments in ocular drug delivery with the promise of greater efficacy and durability of AMD treatment.

关键词： Age-related macular degeneration(AMD) ocular drug delivery gene therapy drug delivery systems port delivery system

The development of polycarbophil as a bioadhesive material in pharmacy

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Asian Journal of Pharmaceutical Sciences 2013年第4期8卷 218-227页

作者： Zhaolu Zhu Yinglei Zhai Ning Zhang Donglei Leng Pingtian Ding School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Medical Devices Shenyang Pharmaceutical UniversityShenyang 110016China

Polycarbophil(PCP),a kind of pharmaceutical polymers with superior bioadhesive properties has been widely used in the field of controlled drug delivery *** could be used as a highly efficient thickener,bioadhesive agent,suspending aid and emulsion stabilizer when dispersed in water or other polar *** exceptional utilities of the polymers result from their hydrophilic *** bonding plays an important role in most adhesion behaviours and becomes the main adhesion *** paper reviews the applications of PCP in pharmacy over the past decades,and clarifies its unique advantages in the bioadhesive *** an introduction discussing its structural characteristics and action mechanism,the focus turned to the description of its available applications in detail with particular emphasis on the ocular,nasal,vagina and oral drug delivery *** other less developed formulations are also described,including the buccal and the transdermal delivery systems.

关键词： Polycarbophil Bioadhesive Hydrogen bonding Bioavailability drug delivery systems

Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma(Danshen)

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Chinese Herbal Medicines 2021年第1期13卷 78-89页

作者： Ruo-ning Wang Hua-cong Zhao Jian-yu Huang Hong-lan Wang Jun-song Li Yin Lu Liu-qing Di School of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China Jiangsu Engineering Research Center for Efficient delivery System of TCM Nanjing 210046China Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing 210046China

Traditional Chinese medicines(TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems(DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides,proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. Salviae Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge(Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic *** this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both singleand multi-component from Danshen.

关键词： active ingredients challenges and strategies drug delivery systems Salvia miltiorrhiza Bunge Salviae Miltiorrhizae Radix et Rhizoma traditional Chinese medicines

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Engineered microorganisms-based delivery systems for targeted cancer therapy:a narrative review

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Biomaterials Translational 2022年第3期3卷 201-212页

作者： Xin Huang Haoyu Guo Lutong Wang Zengwu Shao Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Microorganisms with innate and artificial advantages have been regarded as intelligent drug delivery systems for cancer therapy with the help of engineering *** numerous studies have confirmed the promising prospects of microorganisms in cancer,several problems such as immunogenicity and toxicity should be addressed before further clinical *** review aims to investigate the developments of engineered microorganisms-based delivery systems for targeted cancer *** main types and characteristics of microorganisms such as bacteria,viruses,fungi,microalgae,and their components are introduced in ***,the engineering strategies and biomaterials design of microorganisms are further *** importantly,we discussed the innovative attempts and therapeutic effects of engineered microorganisms in *** together,engineered microorganisms-based delivery systems hold tremendous prospects for biomedical applications in targeted cancer therapy.

关键词： drug delivery systems engineering strategies microorganisms targeted cancer therapy

Micro/nanomotor: A promising drug delivery system for cancer therapy

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ChemPhysMater 2023年第2期2卷 114-125页

作者： Weihan Zhang Zipeng Zhang Shunli Fu Qingping Ma Yongjun Liu Na Zhang Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)NMPA Key Laboratory for Technology Research and Evaluation of Drug ProductsSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Micro/nanomotors(MNMs)are small-scale devices that can effectively convert various forms of energy into mechanical *** controllable motility and good permeability have attracted the interest of researchers as promising drug carriers in cancer *** with traditional formulations,micro/nanomotor drug delivery systems can greatly improve therapeutic efficiency and reduce the side effects of antitumor *** review mainly discusses the advantages of micro/nanomotor drug delivery systems and the applications of MNMs propelled by exogenous,endogenous,and biohybrid power in cancer ***,the main challenges of the applications of micro/nanomotor drug delivery systems,as well as future development trends and opportunities are discussed.

关键词： Micro/nanomotor Cancer therapy drug delivery systems Controllable movement

Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

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Biophysics Reports 2020年第5期6卷 193-210页

作者： Yingsi Xie Ruslan G.Tuguntaev Cong Mao Haoting Chen Ying Tao Shixiang Wang Bin Yang Weisheng Guo Translational Medicine Center Key Laboratory of Molecular Target & Clinical Pharmacology School of Pharmaceutical Sciences & the Second Affiliated Hospital Guangzhou Medical University Université Paris 13 99 avenue Jean Baptiste Clément Department of cardiovascular medicine the Third Affiliated Hospital Guangzhou Medical University The Sixth Affiliated Hospital Department of Biomedical Engineering School of Basic Medical Sciences Guangzhou Medical University

Rheumatoid arthritis(RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages’ proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive(i.e., p H, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents(nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.

关键词： Rheumatoid arthritis Nanotechnology Stimuli-responsive polymers drug delivery systems

Therapeutic targets of Traditional Chinese Medicine for colorectal cancer

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Journal of Traditional Chinese Medicine 2016年第2期36卷 243-249页

作者： Li Weidong Li Chunsheng Zheng Honggang Chen Guohong Hua Baojin Oncology Department Guang'anmen Hospital China Academy of Chinese Medical Sciences Nephrology department Taizhou Central Hospital Urinary surgery Department Guang'anmen Hospital China Academy of Chinese Medical Sciences

OBJECTIVE: To explore the role of Traditional Chinese Medicine(TCM) in the prevention and treatment of colorectal cancer and identify possible therapeutic targets of TCM to provide clues for the use of TCM for colorectal cancer prevention and treatment in the clinic and to find novel directions for new drug discovery for colorectal ***: We used Pub Med and Google to search for and collect scientific publications for a full evaluation of current evidence in the literature indicating the potential role of Chinese herbal medicines and their respective ingredients as effective ***: We extracted a detailed description of potential therapeutic Chinese herbal medicines and their constituent ingredients that target different mechanisms in colorectal cancer such as gene mutation, dysregulation of signaling pathways, metabolism disorders, and the inflammatory microenvironment, including both conventional and non-conventional ***: TCM may be a promising complementary and alternative therapy for the treatment of colorectal cancer.

关键词： Colorectal neoplasms Medicine Chi nese traditional Prevention and control Therapeu tics drug delivery systems

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Contrast-enhanced and targeted ultrasound

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World Journal of Gastroenterology 2011年第1期17卷 28-41页

作者： Michiel Postema Odd Helge Gilja Emmy Noether Research Group Institute of Medical EngineeringDepartment of Electrical Engineering and Information SciencesRuhr-Universit t Bochum44780 BochumGermany Department of Physics and Technology Un versity of Bergen5007 BergenNorway Department of Engineering The University of HullKingston upon Hull HU6 7RXUnited Kingdom Centre de Biophysique Moléculaire UPR 4301 CNRS affiliated to the University of Orléans45071 OrléansFrance National Center for Ultrasound in Gastroenterology Department of MedicineHaukeland University Hospital5021 BergenNorway Institute of Medicine University of Bergen 5007 BergenNorway

Ultrasonic imaging is becoming the most popular medical imaging modality,owing to the low price per examination and its ***,blood is a poor scatterer of ultrasound waves at clinical diagnostic transmit *** perfusion imaging,markers have been designed to enhance the contrast in B-mode *** so-called ultrasound contrast agents consist of microscopically small gas bubbles encapsulated in biodegradable *** this review,the physical principles of ultrasound contrast agent microbubble behavior and their adjustment for drug delivery including sonoporation are ***,an outline of clinical imaging applications of contrast-enhanced ultrasound is *** is a challenging task to quantify and predict which bubble phenomenon occurs under which acoustic condition,and how these phenomena may be utilized in ultrasonic *** by high-speed photography,our improved understanding of encapsulated microbubble behavior will lead to more sophisticated detection and delivery *** sophisticated methods use quantitative approaches to measure the amount and the time course of bolus or reperfusion curves,and have shown great promise in revealing effective tumor responses to anti-angiogenic drugs in humans before tumor shrinkage *** are beginning to be accepted into clinical *** the long term,targeted microbubbles for molecular imaging and eventually for directed anti-tumor therapy are expected to be tested.

关键词： Ultrasound drug delivery systems drug targeting Sonoporation Contrast media Liver Pancreas Gastrointestinal tract

Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention

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Cancer Biology & Medicine 2014年第1期11卷 44-55页

作者： Olga B.Garbuzenko Gediminas Mainelis Oleh Taratula Tamara Minko Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey Department of Environmental Sciences Rutgers The State University of New Jersey Environmental and Occupational Health Sciences Institute Department of Pharmaceutical Sciences Oregon State University Rutgers Cancer Institute of New Jersey

Objective： Various nanoparticles have been designed and tested in order to select optimal carriers for the inhalation delivery ofanticancer drugs to the lungs. Methods： q-he following nanocarriers were studied： micelles, liposomes, mesoporous silica nanoparticles （MSNs）, poly propyleneimine （PPI） dendrimer-siRNA complexes nanoparticles, quantum dots （QDs）, and poly （ethylene glycol） polymers. All particles were characterized using the following methods： dynamic light scattering, zeta potential, atomic force microscopy, in vitro cyto- and genotoxicity. In vivo organ distribution of all nanopartides, retention in the lungs, and anticancer effects of liposomes loaded with doxorubicin were examined in nude mice after the pulmonary or intravenous delivery. Results： Significant differences in lung uptake were found after the inhalation delivery of lipid-based and non-lipid-based nanoparticles. The accumulation ofliposomes and miceUes in lungs remained relatively high even 24 h after inhalation when compared with MSNs, Q Ds, and PPI dendrimers. There were notable differences between nanoparticle accumulation in the lungs and other organs 1 and 3 h after inhalation or intravenous administrations, but 24 h after intravenous injection all nanoparticles were mainly accumulated in the liver, kidneys, and spleen. Inhalation delivery of doxorubicin by liposomes significantly enhanced its anticancer effect and prevented severe adverse side effects of the treatment in mice bearing the orthotopic model of lung cancer. Conclusion： The results of the study demonstrate that lipid-based nanocarriers had considerably higher accumulation and longer retention time in the lungs when compared with non-lipid-based carriers after the inhalation delivery. These particles are most suitable for effective inhalation treatment of lung cancer.

关键词： Nanoparticles drug delivery systems intravenous administration lung neoplasms inhalation administration

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