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Fundamental Research 2024年第3期4卷 693-694页

作者： Zhao Wang Chenglin Guo Weihong Song Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Institute of AgingKey Laboratory of Alzheimer's Disease of Zhejiang Provincethe Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China

Aging is related to physiological decline and the development of chronic diseases,yet molecular changes and mechanisms underlying the aging process remain unclear.Could certain“dark matter”,such as transposable elements with viral origins in the genome,be activated and participate in the aging process?Excitingly,a study by Liu and colleagues revealed that the reactivation of endogenous retroviruses(ERVs)during aging enhances senescence[1].By using cross-species models and multiple techniques,the team uncovered the unusual role of ERV reactivation as a hallmark and driver of aging.The authors identified that ERV expression is associated with cellular and tissue aging(Fig.1).They found that the accumulation of human ERV group K(HERVK)retrovirus-like particles(RVLPs)mediates aging-promoting effects in recipient cells.

关键词： aging mechanisms driving

Analog spatiotemporal feature extraction for cognitive radio-frequency sensing with integrated photonics

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Light(Science & Applications) 2024年第3期13卷 478-487页

作者： Shaofu Xu Binshuo Liu Sicheng Yi Jing Wang Weiwen Zou State Key Laboratory of Advanced Optical Communication Systems and Networks Intelligent Microwave Lightwave Integration Innovation Center(imLic)Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghaiChina

Analog feature extraction(AFE)is an appealing strategy for low-latency and efficient cognitive sensing systems since key features are much sparser than the Nyquist-sampled data.However,applying AFE to broadband radio-frequency(RF)scenarios is challenging due to the bandwidth and programmability bottlenecks of analog electronic circuitry.Here,we introduce a photonics-based scheme that extracts spatiotemporal features from broadband RF signals in the analog domain.The feature extractor structure inspired by convolutional neural networks is implemented on integrated photonic circuits to process RF signals from multiple antennas,extracting valid features from both temporal and spatial dimensions.Because of the tunability of the photonic devices,the photonic spatiotemporal feature extractor is trainable,which enhances the validity of the extracted features.Moreover,a digital-analog-hybrid transfer learning method is proposed for the effective and low-cost training of the photonic feature extractor.To validate our scheme,we demonstrate a radar target recognition task with a 4-GHz instantaneous bandwidth.Experimental results indicate that the photonic analog feature extractor tackles broadband RF signals and reduces the sampling rate of analog-to-digital converters to 1/4 of the Nyquist sampling while maintaining a high target recognition accuracy of 97.5%.Our scheme offers a promising path for exploiting the AFE strategy in the realm of cognitive RF sensing,with the potential to contribute to the efficient signal processing involved in applications such as autonomous driving,robotics,and smart factories.

关键词： scheme driving smart

Light People:Prof.Kei May Lau,newly elected US NAE member in Hong Kong,talks about future of photonics and women in science

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Light(Science & Applications) 2024年第4期13卷 602-608页

作者： Yating Wan Chenzi Guo Electrical and Computer Engineering the ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology23955-6900 ThuwalSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial Photonics technology remains a driving force in today’s scientific landscape,marked by continuous innovation and crossdisciplinary relevance.In an enlighting conversation with Light:Science&Applications,Prof.Kei May Lau,a pioneer in photonics research,shares her deep insights on the evolution of technologies of LEDs,lasers,challenges of hetero-epitaxy,and the future of micro-LEDs and quantum dot lasers.Recently honored as a member of the US National Academy of Engineering(NAE)for her significant contributions to photonics and electronics using III-V semiconductors on silicon,Prof.Lau stands out as the sole Hong Kong scholar inducted into the NAE this year,joining 114 new and 21 international members.In this exclusive Light People interview,Prof.Lau shares her journey as a pioneering woman in engineering,her commitment to mentorship and academia,and her perspective on advancing female representation in science.The summary provided is distilled from Prof.Lau’s thoughtful responses during the interview.For a deeper exploration of Prof.Lau’s experiences and advice,the full interview is available in the Supplementary material.

关键词： interview lighting driving

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)gene.However,the molecular mechanisms underlying HO remain poorly understood.As a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

Preface for Feature Topic on Human Driver Behaviours for Intelligent Vehicles

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Automotive Innovation 2024年第1期7卷 1-3页

作者： Dongpu Cao Argyrios Zolotas Meng Wang Mohammad Pirani Wenbo Li School of Vehicle and Mobility Tsinghua University30 Shuangqing Rd.Beijing 100084China School of Aerospace Cranfield UniversityCranfieldUK Friedrich List Faculty of Transport and Traffic Sciences Technische Universität DresdenDresdenGermany Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooCanada

1 Introduction With the advancement of sensing,machine learning,and computing systems,automated driving applications have been growing rapidly worldwide.Together with the devel-opment of communication technologies such as dedicated short-range communication,extensively emerging intelli-gent vehicles have been developed to connect with vehicles,pedestrians,infrastructures,and clouds in the transportation network.Thus,intelligent vehicles have become intelligent mobile terminal that carries rich functions and services.

关键词： Driver Together driving

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Editorial

The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 1-2页

作者： Zhang Jie Beijing University of Posts and Telecommunications Beijing 100876China

Integrated circuits(ICs)have become the cornerstone of the information age,driving scientific and technological revolutions and symbolizing strategic national competitiveness.With the continuous adjustment of economic structure and the changing of international relationships,the pivotal role of ICs and related sectors has become increasingly prominent.To address Chinese critical“bottleneck”challenges in this domain,it is necessary to strengthen the research on semiconductor devices,IC design,and manufacturing technologies.

关键词： corners driving symbol

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快速干湿气候振荡与中国古代大规模社会动荡

Science Bulletin 2024年第3期69卷 314-318页

作者：孟先强张灿李根程鉴如蔡洁刘一兰霍利倪振宇张恩楼 State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 21008China Department of Earth Science University of CaliforniaSanta Barbara CA 93106USA Ministry of Education Key Laboratory of Surficial Geochemistry School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China

Climate conditions have long been acknowledged as a pivotal factor shaping regional productivity and influencing available resources,consequently playing an important role in driving social changes throughout human history[1–3].In ancient East Asia,the Chinese agrarian civilization emerged around 4000 years ago in northern China,the region termed the“Central Plains”.This region faced recurrent episodes of large-scale social unrest,profoundly impacting the societal structure and dynastic cycles[4].These episodes were marked by extended civil peasant uprisings and/or incursions from northern nomadic tribes,often spanning decades to centuries[5].Both the agrarian societies in the Central Plains and the husbandry-based nomadic tribes in the vast northern grasslands,characterized by semi-arid and semi-humid climates,were notably sensitive to climate variations[6].

关键词： husbandry driving profound

Insights from a proteomic atlas of human Alzheimer's disease brain tissue

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Neural Regeneration Research 2025年第3期20卷 799-800页

作者： Tomas Kavanagh Eleanor Drummond Brain and Mind Centre and School of Medical Sciences University of SydneyCamperdownNSWAustralia

There is an urgent need to identify new drug targets for Alzheimer's disease(AD). While new immunotherapies show promise, clinical benefit appears low, and side effects are high. A greater understanding of the disease mechanisms driving AD is an essential factor that will facilitate the identification of new, effective drug targets.

关键词： Alzheimer clinical driving

RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling

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International Journal of Oral Science 2023年第1期15卷 148-158页

作者： Gongsheng Yuan Shuting Yang Shuying Yang Department of Basic and Translational Sciences School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaUSA The Penn Center for Musculoskeletal Disorders Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA Center for Innovation&Precision Dentistry Penn Dental Medicine and School of Engineering and Applied SciencesUniversity of PennsylvaniaPhiladelphiaUSA

Tumor-associated macrophages(TAMs)play crucial roles in tumor progression and immune responses.However,mechanisms of driving TAMs to antitumor function remain unknown.Here,transcriptome profiling analysis of human oral cancer tissues indicated that regulator of G protein signaling 12(RGS12)regulates pathologic processes and immune-related pathways.Mice with RGS12knockout in macrophages displayed decreased M1 TAMs in oral cancer tissues,and extensive proliferation and invasion of oral cancer cells.RGS12 increased the M1 macrophages with features of increased ciliated cell number and cilia length.Mechanistically,RGS12 associates with and activates MYC binding protein 2(MYCBP2)to degrade the cilia protein kinesin family member 2A(KIF2A)in TAMs.Our results demonstrate that RGS12 is an essential oral cancer biomarker and regulator for immunosuppressive TAMs activation.

关键词： invasion driving RGS

Graphene-driving novel strain relaxation towards AlN film and DUV photoelectronic devices

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Light(Science & Applications) 2022年第7期11卷 1318-1319页

作者： Hieu.P.T.Nguyen New Jersey Institute of Technology Department of Electrical&Computer EngineeringNewarkNJ 07102USA

Graphene-driving strain-pre-store engineering enables the epitaxy of strain-free AlN film with low dislocation density for DUV-LED and the unique mechanism of strain-relaxation in QvdW epitaxy was demystified.

关键词： driving relaxation strain