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dramatic response to Cabozantinib in a Patient with Refractory Hepatocellular Carcinoma with c-MET Amplification

Journal of Clinical and Translational Hepatology 2023年第3期11卷 747-750页

作者： Yun Beom Sang Gwangil Kim Sohyun Hwang Haeyoun Kang Hong Jae Chon Department of Medical Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnam-siGyeonggi-doKorea Department of Pathology CHA Bundang Medical CenterCHA University School of MedicineSeongnam-siGyeo-nggi-doKorea CHA Future Medicine Research Institute CHA Bundang Medical CenterSeongnam-siGyeonggi-doKorea

We report a case of a patient with c-MET amplified hepato-cellular carcinoma (HCC) who had a dramatic response to cabozantinib despite being refractory to four previous lines of systemic therapy. The patient had previously received re-gorafenib plus nivolumab as first-line treatment, lenvatinib as second-line, sorafenib as third-line, and ipilimumab plus nivolumab as fourth-line treatment in sequence. However, all regimens showed early progression within 2 months. The pa-tient’s HCC was well-controlled, with a partial response (PR) of over 9 months after beginning cabozantinib treatment. Although there were mild adverse events such as diarrhea and elevated liver enzymes, they were tolerable. Next-gen-eration sequencing (NGS) of the patient’s previous surgical specimen indicated amplification of c-MET genes. Although it is well known that cabozantinib has excellent effectiveness for inhibiting c-MET at the preclinical level, to the best of our knowledge this is the first case of dramatic response to cabozantinib in a patient with advanced HCC with c-MET am-plification.

关键词： Hepatocellular carcinoma c-MET amplification Cabozantinib dra-matic response Next-generation sequencing

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